Postponement of canine puberty by neonatal administration of a long term release GnRH superagonist

Faya, M.; Marchetti, Cynthia; Priotto, Marcelo; Grisolia, Michele; D'Francisco, Florencia; Gobello, Cristina

doi:10.1016/j.theriogenology.2018.05.043

Cited by 11 publications

(31 citation statements)

References 20 publications

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“…14 Furthermore, this bitch had a later puberty achievement in relation to the rest of the treated littermates of our previous study. 9 As shown by P 4 concentrations, Bitch 1 ovulated during the pubertal oestrus, showing that the postnatal treatment did not alter the functionality of the gonadal axis. Bitch 3 was in diestrus like Bitch 1, while Bitch 2 was in anestrus.…”

Section: Discussionmentioning

confidence: 86%

“…3,5,6,9 Similarly, sheep immunised with GnRH as neonates presented an impairment of reproduction which exceeded the presence of serum antibodies. 10 Descriptions of neonatal contraceptive protocols have been limited to their short-or medium-term effects 3,5,6,9 and longterm (>2 years) detailed reproductive assessment of these treated animals has not been carried out. Prolonged evaluation will provide additional information about the efficacy and safety of these protocols.…”

Section: Introductionmentioning

confidence: 99%

“…Early postnatal administration of gonadotrophin-releasing hormone (GnRH) analogues has safely decreased sexual hormones concentrations, delayed puberty and caused deterioration of gonadal histomorphometry in laboratory rodents, cats and dogs. 3,5,6,9 Similarly, sheep immunised with GnRH as neonates presented an impairment of reproduction which exceeded the presence of serum antibodies. 10 Descriptions of neonatal contraceptive protocols have been limited to their short-or medium-term effects 3,5,6,9 and longterm (>2 years) detailed reproductive assessment of these treated animals has not been carried out.…”

Section: Introductionmentioning

confidence: 99%

“…During this crucial period, differentiation and development of the genital tract to full functional maturity is mainly dependent on sexual steroids imprinting. Early postnatal administration of gonadotrophin‐releasing hormone (GnRH) analogues has safely decreased sexual hormones concentrations, delayed puberty and caused deterioration of gonadal histomorphometry in laboratory rodents, cats and dogs 3, 5,6,9 . Similarly, sheep immunised with GnRH as neonates presented an impairment of reproduction which exceeded the presence of serum antibodies 10 …”

Section: Introductionmentioning

confidence: 99%

“…Descriptions of neonatal contraceptive protocols have been limited to their short‐ or medium‐term effects 3, 5, 6, 9 and long‐term (>2 years) detailed reproductive assessment of these treated animals has not been carried out. Prolonged evaluation will provide additional information about the efficacy and safety of these protocols.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term reproductive evaluation of a bitch neonatally treated with a gonadotropin‐releasing hormone agonist

Marchetti

Faya

Priotto

et al. 2021

Vet Record Case Reports

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In mammals, high concentrations of gonadotropins are necessary early in life to reach a full-sized pool of ovarian follicles at the age of puberty. This case report describes the reproductive status of a 28-month-old, 9.1 kg, crossbred bitch (Bitch 1) which had been treated neonatally with 18.8 deslorelin acetate subcutaneously for contraceptive purposes. The female had just passed pubertal oestrus when hormones were measured and then spayed. The ovaries were histologically assessed. Two crossbred bitches were used for comparisons. Bitch 1's anti-Müllerian hormone (AMH) and progesterone serum concentrations were 0.35 and 16.7 ng/ml, respectively. The total number of ovarian follicles and proportions were normal and the number of primary and antral follicles was increased. These findings might suggest an enhanced recruitment of the follicle pool to the growing population which could be related to the relatively low AMH concentrations.

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Section: Discussionmentioning

confidence: 86%