Postpartum Septicemia With Mycoplasma hominis

Tully, Joseph G.; Smith, Leon G.

doi:10.1001/jama.1968.03140220075027

Cited by 54 publications

(8 citation statements)

References 11 publications

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“…Most reports include patients with common variable immunodeficiency or X-linked agammaglobulinemia (Bloom et al, 2008). Though postpartum septicemia caused by M. hominis may be due to genitourinary bacterial translocation (Tully and Smith, 1968), immunodeficiency cases commonly are not associated with urinary tract manipulation. This suggests that dissemination of M. hominis may be from acquired from sites outside the genitourinary tract.…”

Section: Discussionmentioning

confidence: 99%

Cardiothoracic Transplant Recipient Mycoplasma hominis : An Uncommon Infection with Probable Donor Transmission

et al. 2017

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The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. PCR was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis PCR may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered.

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Section: Discussionmentioning

confidence: 99%

Cardiothoracic Transplant Recipient Mycoplasma hominis : An Uncommon Infection with Probable Donor Transmission

et al. 2017

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“…The form of the immunological responses in puerperal infections associated with M. hominis has been recorded (Stokes, 1955;Tully and Smith, 1968;Jones and Tobin, 1969), and in one of the cases studied by Stokes a mycoplasma was isolated from an empyema following lobectomy. By inference, if M. hominis played a part, even only a subsidiary role, in respiratory infections, then an increased incidence of antibody would be expected in the patients we have studied compared with others without respiratory disease.…”

Section: Discussionmentioning

confidence: 99%

Antibody toMycoplasma hominisin patients with respiratory disease

Eldridge¹,

Jones²,

Tobin³

1970

J Clin Pathol

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SYNOPSIS An attempt was made to evaluate the role of Mycoplasma hominis in respiratory infection in adults. Sera collected from patients admitted to hospital with respiratory infections were examined for antibody to M. hominis. The incidence of antibody was no higher than that found previously in patients without respiratory disease.A number of different species of mycoplasmas can be isolated from the upper respiratory tract of man but little evidence has been produced that they behave as pathogens. The exception is Mycoplasma pneumoniae which is well recognized as a respiratory pathogen and is rarely isolated from the oropharynx of healthy individuals. M

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“…The presence of M. hominis is associated with clinically diverse diseases including; urogenital diseases, postpartum fever [28], pneumonia [15], meningitis, post-operative wound infection, post-organ transplant infection [29] and septic arthritis. The capacity of M. hominis to cause disease has been proven by induction of preterm labour and development of foetal chronic lung disease following experimental in utero administration of M. hominis to pregnant macaque monkeys [19].…”

Section: Introductionmentioning

confidence: 99%

Genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of Mycoplasma hominis

et al. 2016

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Background Mycoplasma hominis is an opportunistic human pathogen, associated with clinically diverse disease. Currently, there is no standardised method for typing M. hominis, which would aid in understanding pathogen epidemiology and transmission. Due to availability and costs of whole genome sequencing and the challenges in obtaining adequate M. hominis DNA, the use of whole genome sequence analysis to provide clinical guidance is unpractical for this bacterial species as well as other fastidious organisms.ResultsThis study identified pan-genome set of 700 genes found to be present in four published reference genomes. A subset of 417 genes was identified to be core genome for 18 isolates and 1 reference. Leave-one-out analysis of the core genes highlighted set of 48 genes that are required to recapture the original phylogenetic relationships observed using whole genome SNP analysis. Three 7-locus MLST schemas with high diversity index (97%) and low dN/dS ratios (0.1, 0.13, and 0.11) were derived that could be used to confer good discrimination between strains and could be of practical use in future studies direct on clinical specimens.ConclusionsThe genes proposed in this study could be utilised to design a cost-effective and rapid PCR-based MLST assay that could be applied directly to clinical isolates, without prior isolation. This study includes additional genomic analysis revealing high levels of genetic heterogeneity among this species. This provides a novel and evidence based approach for the development of MLST schema that accurately represent genomic phylogeny for use in epidemiology and transmission studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3284-z) contains supplementary material, which is available to authorized users.

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Postpartum Septicemia With Mycoplasma hominis

Cited by 54 publications

References 11 publications

Cardiothoracic Transplant Recipient Mycoplasma hominis : An Uncommon Infection with Probable Donor Transmission

Cardiothoracic Transplant Recipient Mycoplasma hominis : An Uncommon Infection with Probable Donor Transmission

Antibody toMycoplasma hominisin patients with respiratory disease

Genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of Mycoplasma hominis

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