Postoperative thrombotic thrombocytopenic purpura after aortofemoral bypass

Mainali, Naba Raj; Aryal, Madan Raj; Badal, Madan; Bhatt, Vijaya Raj; Alweis, Richard

doi:10.3402/jchimp.v2i4.19797

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Occurrence of TTP after surgery is rare but has been described in the literature following vascular, cardiac, and gastrointestinal procedures [ 5 – 8 ]. TTP after orthopedic surgery is even more exceedingly rare with only four case reports existing in the literature to our knowledge [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Postoperative Thrombotic Thrombocytopenic Purpura after Total Hip Arthroplasty: A Case Report and Review of the Literature

Patel

Shah

Sadlack

2018

Case Reports in Orthopedics

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Thrombotic thrombocytopenic purpura (TTP) is an uncommon and potentially lethal microangiopathy that carries a >90% mortality rate if not treated urgently and appropriately. Postoperative TTP after orthopaedic procedures is particularly rare with only four case reports existing in the literature. We present the case of postoperative TTP in a 57-year-old female who underwent elective total hip arthroplasty. We believe this case adds to the limited literature surrounding the topic. While rare, TTP after orthopaedic procedures poses a real and potentially fatal condition if not managed appropriately. Therefore, it is essential for orthopaedic surgeons to be cognizant of postoperative TTP for timely diagnosis and treatment.

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Section: Introductionmentioning

confidence: 99%

Postoperative Thrombotic Thrombocytopenic Purpura after Total Hip Arthroplasty: A Case Report and Review of the Literature

Patel

Shah

Sadlack

2018

Case Reports in Orthopedics

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“…Cardiovascular surgeries were the most common procedure provoking TMA with coronary artery bypass grafts (CABG) [14][15][16][17][18] or a combination of CABG with another vascular procedure being the second most common. 14,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Of TMAs occurring after abdominal surgery, 26,[31][32][33][34][35][36][37] bowel resection accounted for the most common preceding procedure (n = 6). 17,33,[38][39][40][41][42] In addition, five patients developed TMA following orthopedic procedures.…”

Section: Literature Reviewmentioning

confidence: 99%

Postsurgical thrombotic microangiopathy: Case series and review of the literature

Sridharan

Hook

Leung

et al. 2019

European J of Haematology

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Objectives Describe the clinical presentation, treatment, and outcomes of postsurgical thrombotic microangiopathy (TMA). Methods In this retrospective study, records of individuals diagnosed with TMA developing within 30 days of a surgical procedure at Mayo Clinic from 2000 to 2016 were reviewed. Available literature regarding postsurgical TMA was comparatively reviewed. Results Twenty patients were diagnosed with TMA developing within 30 (median 6.5, range (1‐28)) days) following a procedure. Preceding procedures included orthopedic (n = 4), vascular (n = 4), abdominal (n = 8), thoracic (n = 2), and other (n = 2). Review of the literature identified 65 patients with postsurgical TMA and cardiovascular procedures were the most common preceding surgery. The majority of patients in the current cohort and literature were treated with therapeutic plasma exchange (TPE). Among the evaluable patients in the current cohort, 100% demonstrated response to TPE; however, 25% required the addition of other therapy including eculizumab to maintain a response 80% of patients in the literature demonstrated a response to TPE. Conclusions Although rare, early recognition and treatment of postsurgical TMA can lead to good outcomes. More research is necessary to determine the underlying pathophysiology and optimal treatment for postsurgical TMA.

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“…Die Therapie der pTTP liegt im sofortigen Plasmaaustausch und senkt die Mortalität hierbei auf etwa 20 % [3]. Sollte die Therapie nicht anschlagen, kann eine immunmodulierende Therapie mit Vincristin, Cyclophosphamid, Cyclosporin oder eine Splenektomie erfolgen [6].…”

Section: Diskussionunclassified

Thrombotisch-thrombozytopenische Purpura nach Zirkumzision

Schott

Gross

Netsch

et al. 2016

Urologe

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After circumcision, a young man developed a wound healing disorder. After presenting to our hospital for further wound care, laboratory results showed acute renal failure with hemolytic anemia and thrombocytopenia, which led to the diagnosis of postoperative thrombotic thrombocytopenic purpura (TTP). After therapy with plasma exchange and immunosuppressive therapy with prednisolone and rituximab, the patient recovered with normalization of laboratory results. The TTP is associated with low activity of ADAMTS13 with microvascular platelet aggregation and hemolytic anemia.

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Postoperative thrombotic thrombocytopenic purpura after aortofemoral bypass

Cited by 7 publications

References 21 publications

Postoperative Thrombotic Thrombocytopenic Purpura after Total Hip Arthroplasty: A Case Report and Review of the Literature

Postoperative Thrombotic Thrombocytopenic Purpura after Total Hip Arthroplasty: A Case Report and Review of the Literature

Postsurgical thrombotic microangiopathy: Case series and review of the literature

Thrombotisch-thrombozytopenische Purpura nach Zirkumzision

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