Postoperative survivin expression in stage III non-small cell lung cancer (NSCLC) patients treated with neoadjuvant chemoradiation.

Fidler, Mary J.; Basu, Sreyashi; Kaiser-Walters, K. A.; Hadziahmetovic, Emira; Batus, Marta; Steker, D.; Coon, John S.; Bonomi, Philip

doi:10.1200/jco.2010.28.15_suppl.7034

Cited by 1 publication

(1 citation statement)

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“…Not all TAAs of lung cancer have been investigated in immuno therapeutic studies, and there are understandably many more yet to be discovered. For example, the antigen survivin has recently been found to exist in large quantities in NSCLC [136]. Tumors, including those in lung cancer, have evolved ways of maneuvering around the immune system [15] and many vaccines that fail to induce an immune response do so as a result of these complex mechanisms.…”

Section: Key Observations and Conclusionmentioning

confidence: 99%

Current vaccine updates for lung cancer

Simmons¹,

Magee²,

Nemunaitis³

2010

Expert Review of Vaccines

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Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the early studies of these vaccines, and the future is looking brighter for lung cancer patients as a handful of these immunotherapies reach Phase III trials. In addition, optimizing the induced immune response by these vaccines has become a priority, and a number of techniques are being considered, including addition of adjuvants and combining vaccines, which affect synergy based on their mechanism of action. This review is an update on the current vaccines in production, the benefits observed from their most recent studies, and the upcoming plans for improvements in these immunotherapies.

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Section: Key Observations and Conclusionmentioning

confidence: 99%