Abstract:Recent reports of the incidence of postoperative sore throat following anaesthesia with tracheal intubation have claimed that low volume high pressure cuffs are preferable to those with high volume and low pressure. In this study similar methods were used for evaluating postoperative sore throat. Randomly selected tracheal tubes were used in 56 patients undergoing elective abdominal surgery, followed by direct questioning about sore throat on the first postoperative day. The incidence of postoperative sore thr… Show more
“…Among the various reasons of POST airway inflammation following airway mucosal injury, airway smooth muscle contraction contributed to the problem significantly. 4,6,8 The analgesia due to ketamine was achieved through topical action of ketamine via NMDA antagonistic action and antiinflammatory action. 14,[23][24][25][26] Experimental animal studies have shown that ketamine has protective effect on airway inflammatory injury and also relaxes airway smooth muscles probably via interference with Ca+.…”
Section: Discussionmentioning
confidence: 99%
“…with a low intracuff pressure. 8 Use of topical lidocaine, 9 steroid coated tubes, 10 gargling with azulene sulphonate ketamine and licorice. [8][9][10][11][12][13] Ketamine is N-methyl daspartate (NMDA) receptor antagonist and has been used as gargle or nebulization.…”
Section: Introductionmentioning
confidence: 99%
“…8 Use of topical lidocaine, 9 steroid coated tubes, 10 gargling with azulene sulphonate ketamine and licorice. [8][9][10][11][12][13] Ketamine is N-methyl daspartate (NMDA) receptor antagonist and has been used as gargle or nebulization. [13][14][15] Various preclinical and clinical studies have reported that clonidine produces antinociception regardless of the route of administration (central or peripheral).…”
Background: Postoperative sore throat (POST) consider a minor ailment in patients receiving general anesthesia with endotracheal intubation, seen in 21-65% cases but it causes significant distress and increases postoperative morbidity and patient dissatisfaction. This study was done to compare nebulized ketamine and ketamine with clonidine to treat POST.Methods: This was a prospective, randomized, double-blind control clinical study. After approval from institution ethical and scientific committee, study was conducted in between May 2015-April 2016. Written and informed consent was obtained from 100 patients of either sex aged between 20-65 years. ASA I-II, undergoing surgery in supine position lasting up to two hour. Patients were randomized into two groups Group K (n=50) nebulized with 50 mg ketamine (1cc) + 3cc NS =4cc, Group KC (n=50) nebulized with ketamine 50mg (1cc) + clonidine 150µg (1cc) + 2cc NS for 15 min, before general anaesthesia with endotracheal intubation. The POST and hemodynamic variable were monitored before nebulization, after nebulization, before induction, on arrival to PACU and at 4, 8, 12, 24 hours post operatively. POST was graded on 4 point scale (0-3).Results: Overall incidence of POST was 46% (Group K-40%, KC-6%). The Incidence and severity of POST were significantly attenuated in Group KC in comparison to Group K at 4 hours (P= 0.002), 8 hours (P=0.000), 12 hours (P= 0.000) and at 24 hours (P=0.000).Conclusions: Preoperative nebulization with clonidine and ketamine mixture compared to ketamine is more effective in dealing with postoperative sore throat with no adverse effects.
“…Among the various reasons of POST airway inflammation following airway mucosal injury, airway smooth muscle contraction contributed to the problem significantly. 4,6,8 The analgesia due to ketamine was achieved through topical action of ketamine via NMDA antagonistic action and antiinflammatory action. 14,[23][24][25][26] Experimental animal studies have shown that ketamine has protective effect on airway inflammatory injury and also relaxes airway smooth muscles probably via interference with Ca+.…”
Section: Discussionmentioning
confidence: 99%
“…with a low intracuff pressure. 8 Use of topical lidocaine, 9 steroid coated tubes, 10 gargling with azulene sulphonate ketamine and licorice. [8][9][10][11][12][13] Ketamine is N-methyl daspartate (NMDA) receptor antagonist and has been used as gargle or nebulization.…”
Section: Introductionmentioning
confidence: 99%
“…8 Use of topical lidocaine, 9 steroid coated tubes, 10 gargling with azulene sulphonate ketamine and licorice. [8][9][10][11][12][13] Ketamine is N-methyl daspartate (NMDA) receptor antagonist and has been used as gargle or nebulization. [13][14][15] Various preclinical and clinical studies have reported that clonidine produces antinociception regardless of the route of administration (central or peripheral).…”
Background: Postoperative sore throat (POST) consider a minor ailment in patients receiving general anesthesia with endotracheal intubation, seen in 21-65% cases but it causes significant distress and increases postoperative morbidity and patient dissatisfaction. This study was done to compare nebulized ketamine and ketamine with clonidine to treat POST.Methods: This was a prospective, randomized, double-blind control clinical study. After approval from institution ethical and scientific committee, study was conducted in between May 2015-April 2016. Written and informed consent was obtained from 100 patients of either sex aged between 20-65 years. ASA I-II, undergoing surgery in supine position lasting up to two hour. Patients were randomized into two groups Group K (n=50) nebulized with 50 mg ketamine (1cc) + 3cc NS =4cc, Group KC (n=50) nebulized with ketamine 50mg (1cc) + clonidine 150µg (1cc) + 2cc NS for 15 min, before general anaesthesia with endotracheal intubation. The POST and hemodynamic variable were monitored before nebulization, after nebulization, before induction, on arrival to PACU and at 4, 8, 12, 24 hours post operatively. POST was graded on 4 point scale (0-3).Results: Overall incidence of POST was 46% (Group K-40%, KC-6%). The Incidence and severity of POST were significantly attenuated in Group KC in comparison to Group K at 4 hours (P= 0.002), 8 hours (P=0.000), 12 hours (P= 0.000) and at 24 hours (P=0.000).Conclusions: Preoperative nebulization with clonidine and ketamine mixture compared to ketamine is more effective in dealing with postoperative sore throat with no adverse effects.
“…Factors contributing to the development of sore throat include trauma to pharyngolaryngeal mucosa from laryngoscopy, placement of a nasogastric tube, or oral suctioning, 2 cuff design, pressure affecting tracheal mucosal capillary perfusion 3,4 and contact of the tracheal tube with the vocal cords and posterior pharyngeal wall resulting in edema or mucosal lesions. 5 The common measures for the prevention of postoperative sore throat include the use of endotracheal tubes with a low intracuff pressure, 4,6 smaller-sized endotracheal tubes, 5 topical lidocaine, 7 steroid coated endotracheal tubes, 8 and inhalation of steroids. 9 Dexamethasone is a potent corticosteroid with analgesic, anti-inflammatory and antiemetic action.…”
Purpose: Dexamethasone may have potential advantages in the prevention of postoperative sore throat. We therefore undertook a study to evaluate the efficacy of intravenously administered dexamethasone in reducing the incidence and severity of postoperative sore throat in patients receiving general anesthesia with endotracheal intubation.
Methods:In a randomized, double-blind and placebo-controlled study, 120 patients receiving general anesthesia with endotracheal intubation were randomly assigned to two groups. Group 1 (control) patients received normal saline 2 mL iv and group 2 (D) patients received dexamethasone 8 mg iv. After surgery, visual analogue scale (VAS) scores at rest and with effort (swallowing movement) for postoperative sore throat were recorded by a blinded observer.
Results:The overall incidence of postoperative sore throat during the first 24 hr following surgery was lower in dexamethasone group (D) compared to the control group (C). Eleven (20%) patients in the dexamethasone group had postoperative sore throat, compared to 31 (56.3%) patients in the control group (P < 0.01). Postoperatively at one hour, three hours, six hours, 12 hr and 24 hr, the VAS scores for postoperative sore throat at rest and during effort were lower in the dexamethasone group (D) compared to the control group (P < 0.01) at corresponding time intervals.
Conclusion:Preoperative administration of dexamethasone 8 mg iv reduces the incidence and severity of postoperative sore throat in patients receiving general anesthesia with endotracheal intubation.
REPORTS OF ORIGINAL INVESTIGATIONS
“…12 Although usually not crucial, the pain from sore throat can be the main complaint when incisional pain is well controlled, particularly by epidural analgesia. To prevent trauma to the pharynx, larynx, and trachea, various measures have been recommended, such as the use of endotracheal tubes with a low intracuff pressure, 11,13 smaller endotracheal tubes, 1 2 steroid coated endotracheal tubes, 14 inhalation of steroids, 1 5 or topical use of lidocaine. 1 6 Ketoprofen {2-(3-benzoylphenyl) propionic acid} belongs to the propionic acid derivatives, which represent a group of analgesic, anti-inflammatory, and antipyretic nonsteroidal anti-inflammatory drugs (NSAIDs).…”
Purpose: To evaluate prospectively the incidence and severity of postoperative sore throat in 63 orotracheally intubated patients undergoing general anesthesia for various surgical procedures and to determine whether postoperative sore throat could be attenuated by treatment with the transdermal nonsteroidal anti-inflammatory drug ketoprofen applied on the anterior skin of the neck during operation.Method: Patients were randomly assigned to have treatment with ketoprofen (ketoprofen group) or to have placebo tape treatment (control group). Postoperative analgesia was obtained by continuous epidural infusion of local anesthetics, and no narcotics were administered intraoperatively or postoperatively. All patients were interviewed postoperatively after 12-20 hr using a scoring scale questionnaire. Sore throat was scored as 0=no sore throat, 1=minimal, 2=mild, 3=moderate, 4=severe.Results: In the control group, 16 of 32 patients had a sore throat. In the ketoprofen group, less patients (ten of 31 patients) had a sore throat (not significant). The severity of sore throat was alleviated significantly in the ketoprofen group (P <0.05).Conclusion: This study suggests the pain caused by tracheal intubation is relieved by intraoperative topical use of transdermal ketoprofen.
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