Postoperative Regression of Desmoplastic Infantile Gangliogliomas: Report of Two Cases

Takeshima, Hideo; Kawahara, Yoshihiro; Hirano, Hirofumi; Obara, So-ichi; Niiro, Masaki; Kuratsu, Jun‐ichi

doi:10.1227/01.neu.0000084165.60662.6d

Cited by 47 publications

(17 citation statements)

References 26 publications

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“…[6][7][8] In a few cases, spontaneous regression has been reported, even after subtotal excision. [9] These tumors rarely recur and recurrences have also shown good response to surgical treatment. A few case reports have documented metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic non-infantile ganglioglioma: A low-grade tumor, report of two patients

2009

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Section: Discussionmentioning

confidence: 99%

Desmoplastic non-infantile ganglioglioma: A low-grade tumor, report of two patients

2009

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“…22,30 There have been reports of DIA/DIGs spontaneously regressing after subtotal resection without further surgical intervention or subsequent cytotoxic therapy. 31 …”

Section: Discussionmentioning

confidence: 99%

Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution’s experience

Naylor¹,

Wohl²,

Raghunathan³

et al. 2018

Journal of Neurosurgery: Pediatrics

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OBJECTIVEThe aim of this study was to describe the clinical presentation, imaging appearance, and differential outcomes based on tumor location in 7 patients with desmoplastic infantile astrocytoma and desmoplastic infantile gangliogliomas (DIA/DIG).METHODSData of 7 patients with histopathology-proven DIA/DIGs and preoperative imaging were retrospectively reviewed, and age, sex, clinical presentation, imaging characteristics, tumor location, surgical procedure, postoperative morbidity, and overall mortality were recorded.RESULTSTwo subgroups of patients with DIA/DIGs were found to exist based on whether their tumor was located in the cerebral hemispheres or suprasellar region. Nearly all patients presented with rapidly enlarging head circumference regardless of tumor location. However, ocular abnormalities, including nystagmus and preference for downward gaze, were specific for patients with suprasellar disease. These patients experienced significant postoperative complications and had poor long-term outcomes. In contrast, patients with hemispheric tumors underwent more extensive resection than patients with suprasellar tumors, had uneventful postoperative courses, and had no documented long-term comorbidities.CONCLUSIONSPostoperative course and long-term outcome for patients with DIA/DIGs were correlated to the anatomical location and radiographic appearance of their tumor at presentation, despite having histologically and molecularly indistinguishable, WHO grade I tumors.

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“…Unfortunately, complete resection is sometimes difficult because of the large size of these tumors and their close attachment to the dura [12]. Nevertheless, even after subtotal removal there have been reports of spontaneous regression after several months [2, 13]. On the other hand, there are cases of DIG with unpredictable behavior.…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic Infantile Ganglioglioma

Alexiou¹,

Stefanaki

Sfakianos³

et al. 2008

Pediatr Neurosurg

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Desmoplastic infantile gangliogliomas (DIG) are rare intracranial tumors that typically occur in infants and involve the cerebral cortex and the leptomeninges. They are usually very large in size and partially cystic. Total resection, if possible, is the treatment of choice, without the need for further adjuvant therapy. We report 2 cases of DIG. In both cases, computed tomography and magnetic resonance imaging revealed supratentorial mixed cystic and solid tumors, which presented as large cystic components with intense contrast enhancement of a mural nodule. The tumors were completely removed by surgery. The histological diagnosis was DIG. On follow-up examinations no tumor recurrence was noted.

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Postoperative Regression of Desmoplastic Infantile Gangliogliomas: Report of Two Cases

Abstract: Our experience suggests that DIGs may include a subgroup of tumors with a tendency for spontaneous regression, possibly attributable to the induction of apoptosis.

Cited by 47 publications

References 26 publications

Desmoplastic non-infantile ganglioglioma: A low-grade tumor, report of two patients

Desmoplastic non-infantile ganglioglioma: A low-grade tumor, report of two patients

Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution’s experience

Desmoplastic Infantile Ganglioglioma

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