Postoperative Radiotherapy with Volumetric Modulated Arc Therapy of Lacrimal Gland Carcinoma: Two Case Reports and Literature Review

Orlandi, Ester; Takanen, Silvia; Giandini, T.; Iannacone, Eva; Fontanella, Walter; Locati, Laura D.; Carrara, M.; Bossi, Paolo; Bergamini, Cristiana; Granata, Roberta; Tombolini, Vincenzo; Ibba, Tullio; Licitra, Lisa; Pignoli, E.; Fallai, C.

doi:10.2217/fon.14.148

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…PTV contained this clinical target volume with a margin of 5 mm. Anatomically, the lacrimal fossa, lateral and superior portions of the orbita were included, consistent with the literature [6]. The PTV resembled an ellipsoid figure expanding into the eyeball and including the left optical nerve .…”

supporting

confidence: 52%

“…In the literature, good visual capacities could be preserved in the majority of patients (68%-91%) [3,8,15], but attention should be paid to keratitis, a serious side effect in 24% of patients in the Esmaeli study, which can lead to blindness [10]. Consequently, some authors discuss the delineation of detailed intraorbital structures as retina or sclera for toxicity evaluation [6]. It has to be kept in mind that visual impairment or blindness is a real danger of the malignancy itself, about which the patient has to be counseled.…”

Section: As Tumor Control Increases Toxicity Attracts Attentionmentioning

confidence: 99%

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Case of Adenoid Cystic Carcinoma of Lacrimal Gland Treated by Eye Sparing Radiation Therapy using 3DCRT Technique

Kumar¹

2020

CTOIJ

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Case PresentationAdenoid Cystic Carcinomas (ACC) represents the most frequent carcinoma of the lacrimal gland with a percentage of 32% [1]. Usual Symptoms comprise, propoptosis, loss of vision, diplopia, epiphora, eye lid swelling and pain [2,3]. Local therapy as surgery or radiation therapy is complicated by the orbital anatomy involving the second, third and sixth cranial nerve and essential structures for ocular function as the lacrimal gland, external and internal muscles, lens and the retina [4]. The following case illustrates the interdisciplinary approach to a rare tumor entity and the considerations made for preserving the orbital structures functionally. PatientA 53 yrs -lady was evaluated for left eye proptosis for 6 months. Ophthalmic examination showed normal vision and a prominent tumor in the superior-temporal quadrant of the left orbit. MRI revealed, a left bulb protrusion due to a sharp demarcated tumor in the left upper quadrant (1.8* 0.7* 2.0 cm) with posterior extension to lateral rectus and left lateral wall of orbit was noticed and thought to be a pleomorphic adenoma (Figure 1). The patient underwent resection of mass by left lateral orbitotomy with osteotomy of left lateral orbital wall . Intraoperatively, the tumor was found to be superficial with extracapsular extension and was consequently removed, supposedly completely. Figure 1: MRI image showing left orbital mass lesion.Pathological examination revealed an ACC of the lacrimal gland . No evidence of perineural invasion and the resection margins were free. Subsequently, the carcinoma was staged as pT2, pNx, cMx [5]. C Kit -Positive in Immunohistochemistry

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confidence: 52%

Section: As Tumor Control Increases Toxicity Attracts Attentionmentioning

confidence: 99%

Case of Adenoid Cystic Carcinoma of Lacrimal Gland Treated by Eye Sparing Radiation Therapy using 3DCRT Technique

Kumar¹

2020

CTOIJ

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“…Very few reports in the literature specifically relates to the use of IMRT or VMAT in LGACC. A case reported by Orlandi et al [ 20 ] presented favorable outcomes in two patients with lacrimal gland cancer treated by postoperative VMAT, with no evidence of disease at 18-month follow-up. To the best of our knowledge, this is the second report describing the use of postoperative VMAT in the management of lacrimal gland malignancies.…”

Section: Discussionmentioning

confidence: 99%

Lacrimal gland adenoid cystic carcinoma: report of an unusual case with literature review

et al. 2021

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Lacrimal gland adenoid cystic carcinomas are rare, aggressive orbital tumors characterized by poor overall prognosis, tendency for local recurrence and metastasis despite aggressive treatment. Treatment continues to be controversial. Many authorities today will often initiate surgery (orbital exenteration with or without bone removal vs. globe-sparing resection) and adjuvant radiotherapy (external beam or proton beam therapy). We introduce a case of lacrimal gland adenoid cystic carcinoma treated with orbital exenteration and adjuvant volumetric modulated arc therapy, and discuss the related literature.

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Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland

et al. 2019

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Postoperative Radiotherapy with Volumetric Modulated Arc Therapy of Lacrimal Gland Carcinoma: Two Case Reports and Literature Review

Abstract: Postoperative VMAT for treatment of lacrimal gland tumors offers improved outcome, with manageable side effects. In the context of photon beam radiotherapy, VMAT emerged as a valuable treatment option for these malignant tumors.

Cited by 4 publications

References 26 publications

Case of Adenoid Cystic Carcinoma of Lacrimal Gland Treated by Eye Sparing Radiation Therapy using 3DCRT Technique

Case of Adenoid Cystic Carcinoma of Lacrimal Gland Treated by Eye Sparing Radiation Therapy using 3DCRT Technique

Lacrimal gland adenoid cystic carcinoma: report of an unusual case with literature review

Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland

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