Postoperative radiotherapy in carcinoma of the cervix: treatment results and prognostic factors

Atkovar, Gülyüz; Uzel, Ömer; Özşahin, Mahmut; Koca, Sevim Baykal; Şahinler, İsmet; Okkan, Sait; Uzel, R

doi:10.1016/0167-8140(95)01570-7

Cited by 27 publications

(19 citation statements)

References 18 publications

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“…Similarly, Gerbaulet et al [7] reported 89% 5-year survival in node negative patients in contrast with 55 % 5-year survival rates in node-positive patients (p < 0.0001). In the series of Atkovar et al [1], the 5-year disease-free survival rates for patients with and those without pelvic node metastases were 82.5% and 36.6% (p = 0.0017).…”

Section: Discussionmentioning

confidence: 95%

Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

et al. 1998

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Section: Discussionmentioning

confidence: 95%

Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

et al. 1998

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“…It was postulated that addition of pelvic irradiation following radical hysterectomy provided improved local control but not increased survival rate in patients with positive pelvic nodes, however, that postoperative irradiation was associated with increased overall urinary morbidity, gastrointestinal morbidity and higher reoperation rate [18]. Atkovar et al [19] assessed the role of postoperative radiotherapy following surgery for clinical early stage carcinoma of the cervix and concluded that postoperative radiotherapy should be used in patients who had undergone simple hysterectomy and who had unfavorable pathological findings following radical hysterectomy. In the light of these findings, we conclude that since the overall incidence of complications still remains high, the procedure must be performed by a skilled surgeon with sufficient experience to reduce morbidity.…”

Section: Discussionmentioning

confidence: 99%

Complications of Radical Hysterectomy: Clinical Experience of 115 Early Stage Cervical Cancers

Zorlu¹,

Aydoğdu²,

Ergün³

et al. 1998

Gynecol Obstet Invest

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We evaluated the clinical experience of 115 women with early stage cervical cancer who had been operated in our Gynecologic Oncology Clinic. Of these, 85 were in stage I, and 30 in stage II. Intraoperative complications occurred in 16 patients including 3 cases concerning bladder, 1 ureter, 1 aorta, 5 v.cava inferior, 1 internal iliac a., 3 internal iliac v., 1 obturator nerve and 1 recto-vaginal septum hematoma formation. Postoperative complications were observed in 38 patients. These were 14 bladder dysfunctions, 10 lymphocyst formations, 6 urinary infections, 12 wound infections, 3 pelvic infections, 2 eviscerations and 1 incisional hernia. However, no death occurred due to intraoperative or postoperative complications. Pelvic lymph node metastases were observed in 32 patients of whom 17 had only unilateral involvement, most often in the obturator region. Para-aortic lymph node metastases were diagnosed in 4 patients, all of whom were in stage II.

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“…Die Absiedlung von Metastasen in die lokoregionären Lymphknoten ist der wichtigste Prognosefaktor [2,5,11,17,27,30,32,36]. Allein die Tatsache, dass eine Lymphknotenmetastasierung vorliegt, erhöht die Sterblichkeit erheblich, in der mehrfaktoriellen Analyse um den Faktor 3.…”

Section: Diskussionunclassified

“…Zur kombinierten Radiochemotherapie in der adjuvanten Situation gibt es bisher nur eine randomisierte Studie [25]. Die Bedeutung einer alleinigen adjuvanten Bestrahlung wird eher kontrovers diskutiert [2]; nach Sedlis et al [28] wird die Lokalrezidivquote durch die Radiatio gesenkt, ohne einen Einfluss auf das Gesamtüberleben zu haben.…”

Section: Introductionunclassified