Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

Chatani, Masashi; Nose, Takayuki; Masaki, N; Inoue, Toshihiko

doi:10.1007/bf03038982

Cited by 48 publications

(33 citation statements)

References 18 publications

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“…However, the observed disparity is more likely a function of the observed heterogeneity among study methods (eg, assessment methods and length of followup) than it is of the particular characteristics of the solid tumors reviewed. Increased lymphedema risk was observed for patients undergoing pelvic dissections (22%), 18,23,26,30,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] as well as for those undergoing radiation therapy (31%). 17,24,25,33,36-38,40,42,43,45,46,48,50-54 The high incidence of lymphedema observed for gynecological malignancies (20%) is not surprising given that approximately 70% of the patients in these studies were reported to have undergone pelvic lymph node dissections and/or radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Lymphedema beyond breast cancer

Cormier

Askew

Mungovan

et al. 2010

Cancer

398

170

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BACKGROUND: Secondary lymphedema is a debilitating, chronic, progressive condition that commonly occurs after the treatment of breast cancer. The purpose of the current study was to perform a systematic review and meta-analysis of the oncology-related literature excluding breast cancer to derive estimates of lymphedema incidence and to identify potential risk factors among various malignancies. METHODS: The authors systematically reviewed 3 major medical indices (MEDLINE, Cochrane Library databases, and Scopus) to identify studies that included a prospective assessment of lymphedema after cancer treatment. Studies were categorized according to malignancy, and data included treatment, complications, lymphedema measurement criteria, lymphedema incidence, and followup interval. A quality assessment of individual studies was performed using established criteria for systematic reviews. Bayesian meta-analytic techniques were applied to derive summary estimates when sufficient data were available. RESULTS: A total of 47 studies (7779 cancer survivors) met inclusion criteria: melanoma (n ¼ 15), gynecologic malignancies (n ¼ 22), genitourinary cancers (n ¼ 8), head/neck cancers (n ¼ 1), and sarcomas (n ¼ 1). The overall incidence of lymphedema was 15.5% and varied by malignancy (P < .001): melanoma, 16% (upper extremity, 5%; lower extremity, 28%); gynecologic, 20%; genitourinary, 10%; head/neck, 4%; and sarcoma, 30%. Increased lymphedema risk was also noted for patients undergoing pelvic dissections (22%) and radiation therapy (31%). Objective measurement methods and longer follow-up were both associated with increased lymphedema incidence. CONCLUSIONS: Lymphedema is a common condition affecting cancer survivors with various malignancies. The incidence of lymphedema is related to the type and extent of treatment, anatomic location, heterogeneity of assessment methods, and length of follow-up. Cancer 2010;116:5138-49.

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Section: Discussionmentioning

confidence: 99%

Lymphedema beyond breast cancer

Cormier

Askew

Mungovan

et al. 2010

Cancer

398

170

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“…9,10 In a previous report, the rate of lymphedema complication in a group of patients who underwent pelvic and para-aortic lymphadenectomy for gynecologic malignancies was found to be 24%. 11 The same researchers suggested that if the surgical approach could be modified, the severity of lymphedema might be reduced.…”

Section: Discussionmentioning

confidence: 95%

An Experimental Lymphoscintigraphy Study in an Acute Unilateral Deep Venous Thrombosis Model

Koç

Burma²,

Uysal³

et al. 2013

Lymphatic Research and Biology

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Background: The aim of this study is to investigate the effect of both inguinal exploration and deep venous thrombosis on lymphatic flow in an experimental model of unilateral acute obstruction of the femoral vein. Methods and Results: Eighteen male New Zealand White rabbits were the subjects of this study. The rabbits were divided into three groups; Group 1 (n = 6, control), Group 2 (n = 6, sham), and Group 3 (n = 6, operation). After the lymphoscintigraphy was performed on the Group 1 animals, the rabbits in Group 2 and Group 3 underwent intervention. In Group 3, the femoral vein was clipped and excised. In Group 2, an inguinal incision was performed and the clip materials were placed beneath the femoral vein. After the surgical intervention, lower extremity lymphoscintigraphy by subcutaneous administration of Tc-99m nanocolloid was performed in dynamic and static manner in Groups 2 and 3 on the second, fifteenth and thirtieth days after the operation. Unilateral impairment of the lymphatic flow in the operated extremity was observed in Group 3 in the early and late postoperative period but unilateral lymphatic impairment was observed in Group 2 in only the late postoperative period. Conclusion: The lymphatic impairment in an operated extremity might be the consequence of surgical intervention rather than acute venous obstruction in cases where both situations are observed.

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“…Seit Einführung der Hochvolttherapie wird in retrospektiven Analysen eine kumulative Inzidenz der Osteoradionekrosen von 0-3% bis zu einer aktuarischen Inzidenz von 11% nach 5 Jahren berichtet [2,3,6,11,15]. In einer systematischen Untersuchung mit Knochenszintigrammen haben Abe et al [1] bei Frauen, die mit durchschnittlich 46 Gy mit 10-MeVPhotonen behandelt worden waren, eine kumulative Inzidenz von Osteoradionekrosen von 34%, die in 22% der Fälle asymptomatisch waren, gefunden.…”

Section: Diskussionunclassified

“…Etwaige Mehranreicherungen wurden nach ihrer Lokalisation beschrieben und die Speicherungsintensität im Vergleich zu Femur und Lendenwirbelsäule als Referenzknochen als gering, mäßig oder stark gewertet. Die im CT sichtbaren knöchernen Veränderungen wurden nach den Kriterien der RTOG klassifiziert: G3 = dichte Sklerose, G4 = Nekrose/Spontanfraktur [6]. Als Osteoradionekrose werden in der CT nachweisbare Frakturen mit und ohne Sklerose oder Kallusbildung, immer aber ohne begleitende weichteildichte Raumforderung, definiert (Abbildung 1).…”

Section: Introductionunclassified