Postoperative radiotherapy for malignant tumors of the parotid gland

Garden, Adam S.; El‐Naggar, Adel K.; Morrison, William H.; Callender, David L.; Ang, K. Kian; Peters, Lester J.

doi:10.1016/s0360-3016(96)00464-6

Cited by 178 publications

(147 citation statements)

References 14 publications

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“…Some studies have also demonstrated perineural invasion as an independent predictor of survival (Garden et al, 1997;Hocwald et al, 2001). Paralleling the results of previously reported studies; grade was an independent predictor of DFS while nodal involvement was an independent predictor of overall survival in the current study.…”

Section: Discussionsupporting

confidence: 91%

“…This histopathological distribution was comparable with the present study. Though FNAC is a readily available, low morbid and cost effective method of diagnosis in major salivary malignancy; the histological diversity of these tumors makes role of FNA controversial (Spiro, 1986;Schlakman and Yousem, 1993;Garden et al, 1997;Brennan et al, 2010). In terms of imaging, MRI remains the radiological tool of choice for assessment of deep lobe parotid tumors, patterns of infiltration and imaging of para-pharyngeal spaces while computed tomography (CT) is most effective when bony erosion is suspected (Armstrong et al, 1992;Burke et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Despite being rare in incidence, malignant tumors of major salivary glands show diverse histological variation. There are limited data on major salivary gland tumor management and outcome from Pakistan. The objective of this study was to share our experience with management of malignant tumors of major salivary glands. Materials and Methods: Patients who received treatment at Shaukat Khanum Cancer Hospital and Research Center from July 2002 to June 2011 with an underlying diagnosis of a major salivary gland malignancy were included. Patient characteristics and treatment modalities were assessed. Local, regional and distant failures were determined. Disease free survival (DFS) and overall survival (OS) were calculated using Kaplan Meier curves and the Log rank test was used to determine statistical significance. Univariate and multivariate analyses were performed using Cox proportional hazard regression. Results: The parotid gland was the primary site of origin in 104 (80%) patients. Mucoepidermoid carcinoma (43%) and adenoid cystic carcinoma (24%) were the most common histological types. Surgery followed by adjuvant radiation remained the mainstay treatment modality with 81 (62%) patients. Nineteen (15%) patients were treated with surgery alone and 30 (23%) patients with locally advanced surgically inoperable tumors received radiation only. Forty one (32%) patients failed the treatment (local 12, regional 11, locoregional 5, distant 13). The expected 5 year DFS and OS were 65% and 74% respectively. On multivariate analysis, grade was the only independent predictor of DFS and nodal involvement was the only independent predictor of overall survival. Conclusions: Employing existing standards of treatment, comparable survival can be achieved in Pakistani population with major salivary gland malignancies as elsehwere in the world.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Although Garden et al 17 demonstrated a disease-free survival rate of 75% at 5 years among 160 patients treated with surgery and postoperative radiotherapy for carcinomas of the minor salivary glands, this percentage decreased to 62% at 10 years and 54% at 15 years, thereby suggesting that nearly half of all patients will experience recurrence with extended follow-up. In a separate series from these investigators, 18 the reported diseasefree survival rates at 5 years, 10 years, and 15 years among 166 patients with major salivary gland cancer were 79%, 71%, and 69%, respectively.…”

Section: Discussionmentioning

confidence: 97%

Late recurrence from salivary gland cancer

Chen

García

Granchi

et al. 2007

Cancer

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BACKGROUND.The purpose of the current study was to determine the incidence of late recurrences, which were defined as those occurring ≥5 years after initial therapy, among patients treated for salivary gland cancer.METHODS.Between 1960 and 2000, 145 patients underwent definitive therapy for localized carcinomas of the salivary glands and were clinically without evidence of disease at 5 years of follow‐up. Cumulative probabilities for developing a subsequent late recurrence were estimated using the Kaplan‐Meier method.RESULTS.The 10‐year and 15‐year cumulative probabilities of late recurrence in patients who were free of disease at 5 years were 13% and 18%, respectively. The crude rates of late recurrence by histologic subtype were adenoid cystic carcinoma (26%), mixed malignant tumor (25%), mucoepidermoid carcinoma (17%), adenocarcinoma (10%), and acinic cell carcinoma (8%). Sites of late recurrence included distant metastasis (17 patients), local recurrence (8 patients), and regional recurrence (2 patients). The median time to late recurrence was 7.1 years (range, 5.2–23.1 years) from the date of initial surgery. Salvage treatment varied according to location of disease recurrence and initial treatment characteristics. The 15‐year estimate of overall survival was 39% for patients who experienced a late recurrence compared with 71% for those who remained free of disease (P = .001).CONCLUSIONS.A significant proportion of patients who are presumed to be cured of their disease at 5 years after initial treatment for salivary gland cancer will be found to develop late disease recurrence with additional follow‐up. Cancer 2008. © 2007 American Cancer Society.

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“…In previous years, many centres used single modality treatment [1,2], but since the beginning of the 1990s there has been a trend towards the addition of postoperative radiotherapy with improved outcome as a result [20].…”

Section: Discussionmentioning

confidence: 99%