Postoperative oral amiodarone versus oral bisoprolol as prophylaxis against atrial fibrillation after coronary artery bypass graft surgery: A prospective randomized trial

Sleilaty, Ghassan; Madi-Jebara, Samia; Yazigi, Alexandre; Haddad, Fadia; Hayeck, Gemma; El‐Rassi, Issam; Ashoush, Ramzi; Jebara, Victor A.

doi:10.1016/j.ijcard.2008.06.034

Cited by 22 publications

(13 citation statements)

References 40 publications

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“…37, 38 In addition to prophylactic antifibrillatory therapy for POAF, identification and control of the risk factors is expected to play an important role in decreasing the rate of new-onset POAF in at-risk cardiac patients. The present results shows that decreased eGFR is significantly associated with a higher rate of new-onset POAF, longer hospital stay and worse 30-day morbidity or mortality.…”

Section: Discussionmentioning

confidence: 99%

Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery

Chua

Shyu

et al. 2013

Circ J

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Section: Discussionmentioning

confidence: 99%

Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery

Chua

Shyu

et al. 2013

Circ J

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“…También se ha reportado que el uso de drogas para la prevención de FA como el uso de betabloqueadores y amiodarona puede reducir la mortalidad a largo plazo en este grupo de pacientes 7,18,19,20 . Los trabajos a largo plazo han mostrado que un importante factor predisponente de mortalidad siguiendo a la cirugía coronaria es la FAPO.…”

Section: Resultsunclassified

“…El bisoprolol fue el BBCS más utilizado en tanto que el BB no cardioselectivo más usado fue el propranolol. Por lo tanto, nuestros hallazgos concuerdan con los de otros autores que reportan incidencias de FAPO entre 10 y 12% con bisoprolol comparado con 30 a 40% en sujetos que recibieron propranolol [18][19][20] . La limitación más importante del estudio es el relativamente bajo número de sujetos incluidos y, en especial, el menor poder estadístico para detectar diferencias signifi- cativas de mortalidad con solo 6 pacientes fallecidos.…”

Section: Discussionunclassified

Bajos niveles de colesterol HDL es un predictor de mortalidad y de fibrilación auricular postoperatoria posterior a la cirugía de revascularización miocárdica

Vargas

Neira

et al. 2015

Rev Chil Cardiol

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Bajos niveles de colesterol HDL es un predictor de mortalidad y de fibrilación auricular postoperatoria posterior... Vargas C., et al.Low HDL level is a predictor of Post Operative Atrial fibrillation and mortality after coronary artery bypass surgeryBackground: Low C-HDL level has been associated to an increased incidence of atrial fibrillation (AF) and cardiovascular mortality. Previously, we have observed that low C-HDL had the same type of association with post operative AF (POAF) and mortality following surgery for coronary artery disease.Aim: to evaluate whether a low C-HDL level is a predictor of POAF and mortality following revascularization surgery in a controlled study. Method:A prospective observational study included 100 consecutive patients undergoing revascularization surgery for stable coronary artery disease (CAD) in sinus rhythm and no prior AF. POAF was defined as AF sustained for more than 5 min or the occurrence of 5 or more episodes of AF extending for more than 5 seconds during the first 5 post operative days. A value <30 mg/dl was considered low C-HDL.Patients were followed for one year. Uni and multivariate analysis were used to identify predictors of POAF and mortality.Results: 31 patients developed POAF. A significant (p=0.017) OR of 5.01 (95% CI 1.3 -18.8) between low C-HDL and POAF was shown. A similar association linked low serum albumin level to POAF (OR 6.4, C.I. 1.6 -26). After 14.1 ± 1.7 months of follow-up global mortality was 6%. Low C-HDL turned out to be a significant predictor of mortality (H.R. 11.1, C.I. 1.1 -38.4, p=0.04).Conclusion: Low C-HDL is an independent predictor of POAF and mortality after coronary artery revascularization surgery.

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“…12 Experimental studies have found that bisoprolol extends ERP of the atria and has a potential antiarrhythmic effect in the treatment of AF. [13][14][15] It is possible to co-administer bisoprolol with propafenone 16 , which due to its high effi ciency, is a drug of fi rst choice for treatment of atrial fi brillation [17][18][19][20] . Based in these fi ndings we can use bisoprolol as the drug for a selective beta-blockade in propafenone treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of selective beta-blockade with bisoprolol in the treatment of recent-onset atrial fibrillation

Negreva

Penev²

2012

Folia Medica

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The incidence of atrial fi brillation has been rapidly increasing in recent years. The increased tonus of the sympathetic nervous system is related to the development of atrial fi brillation. OBJECTIVE: To study the effect of bisoprolol, a highly selective beta-blocker, on patients with recent-onset atrial fi brillation (< 48 hours) for regularization of the rhythm using propafenone. PATIENTS AND METHODS: The study includes 164 patients (81 women, 83 men, age 59.09 ± 10.81) with successfully restored sinus rhythm in recent-onset atrial fi brillation. The patients received either propafenone (group A, n = 82) or a combination of propafenone and bisoprolol (group B, n = 82). The studied patients were randomly allocated to the groups. Propafenone was administered intravenously as a 2 mg/kg bolus followed by infusion of 0.0078 mg/kg/min for 120 min and orally in dosage of 300 mg three times every 8 hours if arrhythmia persisted. Bisoprolol was administered in a single dose at the very beginning of propafenone treatment and only in patients from group B at a dose of 5 or 10 mg. Regularization of the rhythm was assessed at the 3rd, 6th, 12th and 24th hour. RESULTS: In the initial stages of regularization the combined therapy restored the sinus rhythm in a greater number of patients in comparison with the monotherapy (at the 6th hour 67.07% in group B versus 48.78% in group A, P < 0.05; at the 12th hour it was 87.80% versus 75.60%, respectively, P < 0.05). CONCLUSION: Early regularization of rhythm in patients with recent-onset atrial fi brillation reduces the likelihood of recurrent episodes of arrhythmia. This makes the application of selective beta-blockade clinically signifi cant.

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Postoperative oral amiodarone versus oral bisoprolol as prophylaxis against atrial fibrillation after coronary artery bypass graft surgery: A prospective randomized trial

Cited by 22 publications

References 40 publications

Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery

Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery

Bajos niveles de colesterol HDL es un predictor de mortalidad y de fibrilación auricular postoperatoria posterior a la cirugía de revascularización miocárdica

Effect of selective beta-blockade with bisoprolol in the treatment of recent-onset atrial fibrillation

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