Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery

Chua, Su Kiat; Shyu, Kou Gi; Lu, Ming Jen; Hung, Huei Fong; Cheng, Jian; Lee, Shih Huang; Lin, Chia Hsun; Chao, Hung Hsing; Lo, Huey‐Ming

doi:10.1253/circj.cj-13-0273

Cited by 22 publications

(18 citation statements)

References 41 publications

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“…In the general population, the pathophysiology of AF has been extensively studied, yet it remains incompletely understood 19 20 . Similarly, in the context of cardiac surgery, numerous risk factors for POAF have been identified, but the pathophysiology of this entity is still to a large extent elusive 21 22 23 24 . Identification of genetic markers for POAF might be an important step for prevention of this type of operative complication and may provide important insight into the pathogenesis of AF and new therapeutic strategies for individual patients according to relative risk.…”

Section: Discussionmentioning

confidence: 99%

GRK5 polymorphisms and Postoperative Atrial Fibrillation following Coronary Artery Bypass Graft Surgery

Liu

Zhang

Liu

et al. 2015

Sci Rep

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Postoperative atrial fibrillation (POAF) is a serious yet common complication after coronary artery bypass grafting (CABG) surgery. Previous study have identified multiple genetic susceptibility loci for POAF susceptibility after CABG, although some studies are under-powered. However, none of these studies have been conducted among Asians. In current study, we aim to systematically evaluated the previous positive findings for POAF susceptibility after CABG among Chinese population, using a large population-based, two-stage, case-cohort study. From a discovery cohort of 1,348 patients, a total of nine independent loci were evaluated. Six significant SNPs were then assessed in a separately collected validation cohort of 2,000 patients. After adjustment for clinical predictors of POAF, two variants in GRK5 gene (rs4752292, and rs11198893) were replicated with significance were replicated in the validation cohort. The ORs for each additional copy of minor allele were 1.32 (95% CI: 1.15–1.50, P = 5.82 × 10−5) and 1.47 (95% CI: 1.28–1.69, P = 1.16 × 10−7), respectively. In this two-stage independently collected cardiac surgery cohorts, genetic variations in the GRK5 gene are independently associated with POAF risk in patients who undergo CABG surgery in Asians.

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Section: Discussionmentioning

confidence: 99%

GRK5 polymorphisms and Postoperative Atrial Fibrillation following Coronary Artery Bypass Graft Surgery

Liu

Zhang

Liu

et al. 2015

Sci Rep

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“…3,5, 13 The mechanisms underlying the occurrence of AF after CABG, however, have not yet been clarified. Increasing age is the only independent risk factor for postoperative AF occurrence that has been consistently identified.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Hyperglycemia and Atrial Fibrillation After Coronary Artery Bypass Graft Surgery

Tatsuishi

Adachi

Murata

et al. 2014

Circ J

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“…In patients undergoing cardiac surgery, LVDD correlates with difficult weaning from cardiopulmonary bypass and higher inotropic needs [ 24 , 25 ]. Moreover, there is some evidence of correlation between advanced LVDD and postoperative AF after cardiac surgery [ 26 , 27 ].…”

Section: Main Textmentioning

confidence: 99%

Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care

Sanfilippo

Scolletta

Morelli

et al. 2018

Ann. Intensive Care

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There is growing evidence both in the perioperative period and in the field of intensive care (ICU) on the association between left ventricular diastolic dysfunction (LVDD) and worse outcomes in patients. The recent American Society of Echocardiography and European Association of Cardiovascular Imaging joint recommendations have tried to simplify the diagnosis and the grading of LVDD. However, both an often unknown pre-morbid LV diastolic function and the presence of several confounders—i.e., use of vasopressors, positive pressure ventilation, volume loading—make the proposed parameters difficult to interpret, especially in the ICU. Among the proposed parameters for diagnosis and grading of LVDD, the two tissue Doppler imaging-derived variables e′ and E/e′ seem most reliable. However, these are not devoid of limitations. In the present review, we aim at rationalizing the applicability of the recent recommendations to the perioperative and ICU areas, discussing the clinical meaning and echocardiographic findings of different grades of LVDD, describing the impact of LVDD on patients’ outcomes and providing some hints on the management of patients with LVDD.

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Association Between Renal Function, Diastolic Dysfunction, and Postoperative Atrial Fibrillation Following Cardiac Surgery

Cited by 22 publications

References 41 publications

GRK5 polymorphisms and Postoperative Atrial Fibrillation following Coronary Artery Bypass Graft Surgery

GRK5 polymorphisms and Postoperative Atrial Fibrillation following Coronary Artery Bypass Graft Surgery

Postoperative Hyperglycemia and Atrial Fibrillation After Coronary Artery Bypass Graft Surgery

Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care

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