Postoperative Malignant Hyperthermia

Litman, Ronald S.; Flood, Christopher; Kaplan, Richard F.; Kim, Yung Ly; Tobin, Joseph R.

doi:10.1097/aln.0b013e31818958e5

Cited by 79 publications

(30 citation statements)

References 24 publications

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“…MH was however ruled out as symptoms of MH after sevoflurane anesthesia occurs within 24 h and are unlikely after 72 h.[3] Serotonin syndrome was ruled out because patient was not on any selective serotonin reuptake inhibitors (SSRIs) or selective serotonin-norepinephrine reuptake inhibitors (SSNRIs)…”

Section: Discussionmentioning

confidence: 99%

Neuroleptic malignant syndrome: A diagnostic challenge

Ambulkar

Patil

Moiyadi

2012

J Anaesthesiol Clin Pharmacol

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We report the case of a 7-year-old girl operated for craniopharyngioma who developed hyperkalemic cardiac arrest in the post-operative period. She was diagnosed as Neuroleptic malignant syndrome (NMS) and the causative drug was carbamazepine. It was essentially a diagnosis of exclusion, and treatment was mainly supportive in form of withdrawal of the neuroleptic medication (carbamazepine) and administration of dantrolene and bromocriptine. Although, relatively uncommon, NMS can be fatal. NMS presents a clinical challenge as the patient outcome depends on its prompt recognition and treatment.

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Section: Discussionmentioning

confidence: 99%

Neuroleptic malignant syndrome: A diagnostic challenge

Ambulkar

Patil

Moiyadi

2012

J Anaesthesiol Clin Pharmacol

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“…MH reaction may occur at any time during general anaesthesia as well as in the postoperative period [1,2,14,16]. Its course may be extremely abrupt, or its signs and symptoms may develop slowly and atypically.…”

Section: Symptoms and Clinical Coursementioning

confidence: 99%

“…Moreover, the first symptoms may occur in the postoperative period. Litman et al [16] analysed 528 MHE in North America. Ten of the analysed cases occurred in the postoperative period, up to 40 minutes after the completion of general anaesthesia.…”

Section: Symptoms and Clinical Coursementioning

confidence: 99%

Malignant hyperthermia – what do we know in 2019?

Cieniewicz¹,

Trzebicki²,

Mayzner-Zawadzka³

et al. 2019

ait

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Malignant hyperthermia (MH) is a life-threatening syndrome caused by sudden, uncontrolled skeletal muscle hypermetabolism in response to inhalation anaesthetics and depolarizing muscle relaxants. MH is related to an abrupt, massive release of calcium from the endoplasmic reticulum. False diagnosis and lack of targeted therapy are associated with high mortality rates; therefore, continuous education and knowledge updating are required. Our aim was to present the most recent data concerning epidemiology, genetics, pathophysiology, clinical course, treatment, and diagnosis of MH.

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“…In most reported cases, MH occurred during administration of the triggering agents; however, there are few reported cases in which the onset of MH began in the postoperative period. [1] We report a case of suspected MH presenting postoperatively after a written informed consent of the parents of the patient was obtained.…”

mentioning

confidence: 99%