Postoperative magnesium sulphate infusion reduces analgesic requirements in spinal anaesthesia

The Effect of Intravenous Magnesium Therapy on Spinalanaesthesia Produced by Bupivacaine In Pre-Eclamptic Patients

“…However, Ozalevliet al 17 used the same intrathecal drug combination as Malleeswaran et al 18 and reported no difference in motor block recovery. Sensory block levels achieved in these two studies as well as the patient population may be responsible for their conflicting results.Our results are in accordance with those of Apanet al 3 , who found a similar duration of motor block but prolonged first analgesic request in their IV magnesium infusion group. Although not statistically significant, less hypotensive episodes were observed in the pre-eclamptic group, resulting in statistically significant decreased fluid requirements in our study.…”

“…In all of these studies, lower doses of MgSO 4 (ranging from 1.03 g to 12.35 g) were used and the infusions were started after lumbar puncture. In contrast to these studies [3][4][5] , in our study, pre-eclamptic patients received MgSO 4 before spinal anaesthesia and the lowest total dose of magnesium was 28.5 g in a patient with the shortest infusion duration of 12 hours.…”

“…There are a few studies which have looked at the analgesic effects of IV magnesium in patients undergoing spinal anaesthesia and only few of them have included an obstetric population [3][4][5] . In all of these studies, lower doses of MgSO 4 (ranging from 1.03 g to 12.35 g) were used and the infusions were started after lumbar puncture.…”

“…1,2 Several studies have been done in non-obstetric populations which reported intravenous (IV) magnesium administration to be beneficial for postoperative analgesia following neuraxialanaesthesia [3][4][5][6] , whereas one study could not demonstrate this effect 7 . This controversy can be justified by the fact that, in healthy humans, the passage of magnesium to cerebrospinal fluid (CSF) is limited when administered intravenously 1 .…”

Comparison of intravenous Magnesium Sulphate with intrathecal Magnesium Sulphate for post- operative analgesia in orthopaedic patients undergoing extracapsular hip fracture surgery

“…2,3 Numerous clinical investigations have demonstrated that Mg infusion during general anaesthesia reduces anaesthetic requirement and postoperative analgesic consumption, whereas other studies suggested that perioperative IV (intravenous) Mg administration had little effect on postoperative pain. 4,5 It is likely that intrathecal magnesium sulphate potentiates spinal anaesthesia by a localized action on spinal nociceptive pathways, explaining the absence of central side-effects after systemic administration of large doses of magnesium. 6 As intrathecal magnesium alone has been shown to induce sensory and motor block.…”