Postoperative Complications Predict Long-term Outcome After Curative Resection for Perforated Colorectal Cancer

Hashimoto, Shintaro; Hamada, Kiyoaki; Sumida, Yorihisa; Araki, Motoo; Wakata, Kouki; Kugiyama, Tota; Shibuya, Ayako; Nishimuta, Masato; Morino, Saori; Baba, Masayuki; Kiya, Soichiro; Ozeki, Keisuke; Nakamura, Akihiro

doi:10.21873/invivo.12291

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…There has been improvement in the outcomes of various treatment modalities, including surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy, for patients with colorectal cancer. Specifically, radical resection is crucial for treatment; additionally, the completeness of oncologic resection is a crucial factor affecting the prognosis [2,3]. However, colorectal surgery has higher postoperative infectious complications than other surgery types given the direct surgical manipulation and preoperative preparation strategies of the large intestine, where bacteria are most abundant [4,5].…”

Section: Introductionmentioning

confidence: 99%

Perioperative Probiotics Application for Preventing Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review and Meta-Analysis

Kim²,

Kim³

et al. 2022

Medicina

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Background and Objectives: Perioperative probiotic administration in patients who undergo gastrointestinal surgery can reduce postoperative infectious complications. This systematic review and meta-analysis aimed to evaluate the effect of probiotics on postoperative outcomes in patients who underwent colorectal cancer surgery. Materials and Methods: For this study, we followed the protocol published by PROSPERO (registration number: CRD42021247277). We included studies on patients undergoing open, laparoscopic, or robotic colorectal cancer surgery for curative intent. We conducted a comprehensive search with online databases (trial registries and ClinicalTrials.gov), other literature sources, and conference proceedings, with no language restriction, up until 12 August 2022. We assessed risk of bias, extracted data, and conducted statistical analyses by using a random-effects model and interpreted the results based on the Cochrane Handbook for Systematic Reviews of Interventions. We rated the certainty of evidence (CoR) according to the GRADE approach. Results: We identified 20 published full-text studies. The use of probiotics probably results in little to no difference in perioperative mortality (risk ratio (RR): 0.17, 95% CI: 0.02 to 1.38; I2 = 0%; moderate CoE) and may result in reducing the overall postoperative infectious complications (RR: 0.45, 95% CI: 0.27 to 0.76; I2 = 38%; low CoE) after colorectal cancer surgery. Probiotics may result in little to no difference in probiotics-related adverse events (RR: 0.73, 95% CI: 0.45 to 1.19; I2 = 0%; low CoE). While probiotics may result in reducing the overall postoperative complications (RR: 0.47, 95% CI: 0.30 to 0.74; I2 = 8%; low CoE), it may result in little to no difference in hospital length of stay (LOS) (MD: −1.06, 95% CI: −1.64 to −0.47; I2 = 8%; low CoE) and postoperative quality of life (QOL) (MD: +5.64, 95% CI: 0.98 to 10.3; low CoE). Conclusions: Perioperative probiotic administration may reduce complications, including overall infectious complications, in patients undergoing colorectal cancer surgery without any additional adverse effects. In addition, probiotics may have similar effects on perioperative mortality; procedure-related complications such as anastomotic leakage, and hospital LOS; or improve the QOL. Thus, probiotics may be considered a beneficial supplement to routine perioperative care for colorectal cancer surgery.

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Section: Introductionmentioning

confidence: 99%

Perioperative Probiotics Application for Preventing Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review and Meta-Analysis

Kim²,

Kim³

et al. 2022

Medicina

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“…Studies report that 79e82% of their PCC patients were treated with emergency surgery [3,10,11]. Therefore, not all colon cancer patients that show signs of perforation need emergency surgery.…”

Section: Discussionmentioning

confidence: 99%

“…When involving tumour necrosis this type of perforation is commonly contained [7,9]. Both main types of perforation are challenging to manage [3,4,9,10]. Perforation at the tumour site can also be caused by colonoscopy or endoscopic interventions such as biopsy or stenting, but these iatrogenic perforations are outside the scope of the present review.…”

Section: Introductionmentioning

confidence: 96%

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Outcomes of patients with perforated colon cancer: A systematic review

Zamaray

Velzen

Snæbjörnsson

et al. 2023

European Journal of Surgical Oncology

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“…The postoperative complications of colorectal cancer often have a negative effect on the survival rate of patients. 20,21 The 3-and 5-year survival rates of patients with cecal adenocarcinoma increase gradually during the three observation periods and may benefit from advances in insurance plans and screening methods. 22 The insurance plan includes the popularity of colonoscopy, which helps enable tumors to be detected at an early stage.…”

mentioning

confidence: 99%

Evaluation and Prediction Analysis of 3- and 5-Year Survival Rates of Patients with Cecal Adenocarcinoma Based on Period Analysis

Shao¹,

Zheng²,

Chen³

et al. 2021

IJGM

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Background: Cecal adenocarcinoma has a high degree of malignancy and poor prognosis, thereby bringing serious disease burden to patients. The long-term survival rate of patients with cecal adenocarcinoma deserves us to explore more deeply. In addition, appropriate methods that evaluate the survival outcome of cecal adenocarcinoma are few. Methods: This study used the data provided by the Surveillance, Epidemiology, and End Results (SEER) database to evaluate and predict the survival rates of patients with cecal adenocarcinoma from 2002 to 2016 and from 2017 to 2021, respectively. The cohort of population taken are all older than 20 years old, which is from National Cancer Institute. The period analysis was used to check the data in the SEER database. Reliable results could be obtained using period analysis, which provided important information for prevention and treatment strategies. Results: From 2002 to 2016, the relative survival rate of patients with cecal adenocarcinoma increased yearly. Compared with those in previous 15 years, the relative survival rate between 2017 and 2021 still increased but to a low extent. The relative survival rates of patients with cecal adenocarcinoma were remarkably different in terms of age, sex, race, differentiation grade, stages, and socioeconomic status. Even if there is a significant improvement, the survival rate of patients with distant-stage cancer is at a very low level. Conclusion:Understanding the survival rate of patients with cecal adenocarcinoma in the past 15 years is helpful in predicting the future trend and providing basic data and scientific basis to evaluate the harm of cecal adenocarcinoma to patients' health, prepare cancer prevention plans, and evaluate the effect of cancer prevention and treatment by exploring the differences in survival rate corresponding to different ages, sexes, races, differentiation grades, stages, and socioeconomic status.

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Postoperative Complications Predict Long-term Outcome After Curative Resection for Perforated Colorectal Cancer

Cited by 6 publications

References 17 publications

Perioperative Probiotics Application for Preventing Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review and Meta-Analysis

Perioperative Probiotics Application for Preventing Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review and Meta-Analysis

Outcomes of patients with perforated colon cancer: A systematic review

Evaluation and Prediction Analysis of 3- and 5-Year Survival Rates of Patients with Cecal Adenocarcinoma Based on Period Analysis

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