Outcomes of patients with perforated colon cancer: A systematic review

Zamaray, Bobby; Velzen, R. van; Snæbjörnsson, Pétur; Consten, Esther C. J.; Tanis, Pieter J.; Westreenen, Henderik L. van

doi:10.1016/j.ejso.2022.08.008

Cited by 5 publications

(2 citation statements)

References 23 publications

(80 reference statements)

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“…Our data shows that POC was more common in individuals who had an abdominal CT scan with a perforation detectable by free air. A previous systematic review concluded that individuals with colon cancer who first experienced a perforation had lower overall survival rates and a greater incidence of POC [ 26 ]. This could explain why emergent colorectal cancer due to perforation is a reflection of an advanced disease that has not been identified and treated at an earlier stage; consequently, this highlights the importance of increasing public awareness regarding early colorectal cancer screening.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Factors That Contribute to Intraoperative and Postoperative Complications Following Colorectal Cancer Surgeries at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Alzahrani,

Alturkistani,

Alturki

et al. 2024

Cureus

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Background: Colorectal cancer (CRC) is a major contributor to cancer-related mortality and morbidity due to its high prevalence. Surgery remains the curative option. Colorectal cancer patients come to our institute at an advanced stage due to the lack of adequate national screening programs in developing countries. This carries a particularly high risk of morbidity and mortality. In this study, we aim to provide an overview of the complications of colorectal cancer surgery and to describe the preoperative and intraoperative factors associated with it. Methods: This retrospective record review was done at King Abdulaziz University Hospital (KAUH), a tertiary center in Jeddah, Saudi Arabia. It included all patients aged 18 and older who have undergone colorectal cancer surgeries from January 2017 until August 2022. Results: In our sample of 195 patients, 52.3% of the patients were males. The mean age of our sample was 59.32 ± 13.21. We found that 19 (9.7%) patients had an intraoperative complication (IOC). The most frequent IOC was bleeding reported in seven patients (3.6%), followed by intestinal injury in three (1.2%), bladder injury in three (1.2%), and ureter injury in three (1.2%). Regarding preoperative lab tests, patients who had low blood albumin levels (P = 0.004) and high preoperative white blood cell count (WBC; P = 0.015) were more likely to experience IOC. There was a statistically significant relationship between the patient's ASA score and IOC (P = 0.011). Postoperative complications (POC) occurred in 58 patients (29.7%). The most frequent POC was surgical site infection (SSI; 16.4%), followed by urinary tract infections (UTI) (6.7%) and prolonged postoperative ileus (5.6%). Patients who initially presented with vomiting (P = 0.015), had free air on a preoperative abdominal computed tomography (CT) scan (P = 0.028), required intraoperative blood transfusions (P = 0.033), were diagnosed with transverse colon tumors (P = 0.045), and required longer hospital stays (P = 0.011) were found to have a higher rate of POC. Conclusion: The incidence of colorectal cancer is increasing, and surgery is a successful treatment option. However, complications from surgery may result in morbidities and prolonged hospital stays. The risk of IOC is increased by preoperative variables such as high WBC levels, low albumin, and ASA scores. Patients with initial obstruction signs, free air on CT scans, intraoperative blood transfusions, transverse colon tumors, and longer hospital stays have a higher rate of POC. Patient monitoring and the provision of standardized clinical tools enhance general survival and quality of life.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Factors That Contribute to Intraoperative and Postoperative Complications Following Colorectal Cancer Surgeries at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Alzahrani,

Alturkistani,

Alturki

et al. 2024

Cureus

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“…On the other hand, Orive et al reported that perforation was predictive of early recurrence at T2 but not T1 in patients with colon cancer ( 40 ). These discrepancies could be attributed to differences in tumor stages and definitions of perforation across studies ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

Determinants of survival and recurrence in patients with stage I colorectal cancer

Bananzadeh,

Bahadori,

Mohammadianpanah

et al. 2024

Front. Surg.

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BackgroundDue to the novel advanced screening methods, the number of patients diagnosed with stage I colorectal cancer (CRC) is increasing. This retrospective cohort study aimed to identify recurrence and survival risk factors of patients with stage I CRC after surgery.Materials and methodsPatients with stage I CRC were evaluated, and their demographic and clinicopathologic variables were recorded. The log-rank test assessed the association of variables with overall survival (OS), recurrence-free survival (RFS), local recurrence, and distant metastasis.ResultsThe median overall survival period was 51 months. The recurrence rate was 13.7%: 7.2% local and 9.3% distant recurrence. One-, two-, three-, and five-year RFS were 92%, 89%, 87%, and 83%, respectively, and OS were 96%, 93%, 90%, and 89%, respectively. Local and distant recurrence rates were higher in patients with higher tumor grades. Additionally, RFS and OS were worse in patients with higher tumor grades, and perforation was associated with worse OS.ConclusionsThe determinants of survival and recurrence identified in the present study can be used to improve patient outcomes by early diagnosis and appropriate management of high-risk patients.

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Enhanced recovery after surgery protocols following emergency intra-abdominal surgery: a systematic review and meta-analysis

McKechnie,

Tessier,

Archer

et al. 2023

Eur J Trauma Emerg Surg

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Outcomes of patients with perforated colon cancer: A systematic review

Cited by 5 publications

References 23 publications

Evaluation of Factors That Contribute to Intraoperative and Postoperative Complications Following Colorectal Cancer Surgeries at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Evaluation of Factors That Contribute to Intraoperative and Postoperative Complications Following Colorectal Cancer Surgeries at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Determinants of survival and recurrence in patients with stage I colorectal cancer

Enhanced recovery after surgery protocols following emergency intra-abdominal surgery: a systematic review and meta-analysis

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