Postoperative Complications from Breast and Axillary Surgery

Thalji, Sam Z; Cortina, Chandler S.; Guo, Meng S.; Kong, Amanda L.

doi:10.1016/j.suc.2022.08.007

Cited by 6 publications

(4 citation statements)

References 126 publications

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“…Moreover, during the procedure, there are different levels of lymph node dissection according to the particular stage of the disease ( 93 ). The surgical trauma is large, and adverse events related to wound healing are likely to occur after the surgery ( 94 , 95 ). This may cause patients undergoing modified radical surgery to experience a higher level of physical pain.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis

Tao,

Xiang,

Zeng

et al. 2024

Front. Psychiatry

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IntroductionCancer-related distress can be described as a complex and unpleasant combination of psychological (such as cognitive, behavioral, and emotional), social, and spiritual challenges that may impact an individual’s ability to effectively cope with the physical symptoms of cancer and its treatment. Existing literature has confirmed psychological distress (PD) as an important sequela of breast cancer diagnosis and treatment. However, the incidence and risk factors for PD in adult female patients with breast cancer remain unclear; therefore, focusing on the PD of female breast cancer patients is meaningful, as they are at highest risk of contracting breast cancer, and might differ in their coping styles from men.ObjectiveThis review aimed to identify the incidence and risk factors for PD in adult woman patients with breast cancer, and to help guide targeted intervention to prevent distress.MethodPubMed, Embase, Cochrane Library, CINAL, PsycINFO, China Knowledge Resource Integrated Database, Wanfang Database, the Chinese Biomedical Database, and Weipu Database were searched for data regarding the incidence and risk factors of PD in adult women with breast cancer.ResultsThe prevalence of PD, assessed using the distress thermometer, ranged between 11.2%–86.7%, and a meta-analysis of 47 studies with 15,157 adult female breast cancer patients showed that the pooled prevalence was 52.0%. Further, this study identified 40 risk factors. However, owing to the inclusion of at least two studies for a certain risk factor, 10 risk factors were merged for the meta-analysis. Independent risk factors included higher education level, late-stage tumor, emotional concerns, no medical insurance, modified radical mastectomy, and history of depression; age and neuroticism were not associated with PD; and higher monthly income was revealed as a protective factor against it.ConclusionThe incidence of PD in female patients with breast cancer is high and it involves 10 risk factors, though some are controversial owing to insufficient evidence. Further research is needed to explore the underlying mechanisms of PD and develop risk factor-based holistic intervention programs to reduce its incidence.Systematic review registrationThe protocol of this study has been registered in the database PROSPERO (registration ID: CRD42023433578).

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Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis

Tao,

Xiang,

Zeng

et al. 2024

Front. Psychiatry

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“…Generally, surgery of the breast and axillary is specified by low risk of complications [4]. However, it can cause pain, lymphedema, seroma, hematoma, infections, and skin necrosis.…”

Section: Surgerymentioning

confidence: 99%

“…In early-stage BC, surgery is a first-chose therapy. The surgical management of BC involves breast-conserving surgery (BCS), mastectomy (including skinsparing and nipple-sparing types) and modified radical mastectomy [4]. Each surgical method is associated with different rates of surgical morbidity and complications.…”

Section: Introduction and Purposementioning

confidence: 99%

Adverse effects in the management of breast cancer – recent studies

Maksymowicz,

Machowiec,

Korzeniowska

et al. 2023

J Educ Health Sport

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Introduction and purpose Breast cancer (BC) management includes local therapies surgery, radiotherapy and systemic – hormonotherapy, chemotherapy, targeted and immunotherapy. However, some adverse events of these treatment strategies limit their wide administration in BC therapy. The aim of the study was to present adverse effects in the management of BC, prevention and treatment of them. State of the knowledge Surgery of the breast leads to lymphedema, pain, and anatomical changes. The most characteristic adverse event of radiotherapy is radiation dermatitis which is more probable among obese, older patients, females, and smokers. Other side effects are pneumonia, cardiac and pulmonary injury. Chemotherapeutics lead to complications such as anthracyclines-induced cardiotoxicity. As a consequence of endocrine therapy, patients are affected by vasomotor, musculoskeletal, and vulvovaginal symptoms. Immune checkpoint inhibitors may cause immune-related adverse events (irAEs), which are usually mild. When severe irAEs occur, immunosuppressive drugs are used. Depending on stage, toxicities of the therapies can lead to interrupting the treatment of BC. Moreover, drug resistance is an important therapeutic obstacle in BC treatment. Conclusion The application of a diversity of drugs in the treatment of breast cancer is associated with adverse effects which limit its efficacy. It is vital to develop novel, targeted therapeutic methods to optimize outcomes of patients. Given the adverse effects of breast cancer therapies and drug resistance, it is vital to develop novel, targeted therapeutic methods.

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“…NSM has gained popularity due to its better aesthetic outcomes, reduced psychological impact, and improved quality of life for patients. Recent studies have suggested that NSM may offer some advantages over breast-conserving surgery, such as better cosmetic outcomes and a reduced risk of local recurrence ( 5 , 6 ). However, NSM is a more complex and technically demanding procedure that requires specialized training and expertise.…”

Section: Introductionmentioning

confidence: 99%

Comparative effectiveness of nipple-sparing mastectomy and breast-conserving surgery on long-term prognosis in breast cancer

Chen,

Qu,

et al. 2023

Front. Endocrinol.

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BackgroundThe frequency of nipple-sparing mastectomy (NSM) surgery is presently increasing. Nonetheless, there is a paucity of long-term prognosis data on NSM. This study compared the long-standing prognosis of NSM in relation to breast-conserving surgery (BCS).MethodsPopulation-level data for 438,588 female breast cancer patients treated with NSM or BCS and postoperative radiation from 2000 to 2018 were identified in the Surveillance, Epidemiology, and End Results (SEER) database; 321 patients from the Second Xiangya Hospital of Central South University were also included. Propensity score matching (PSM) was performed to reduce the influence of selection bias and confounding variables to make valid comparisons. The Kaplan–Meier analysis, log-rank test, and Cox regression were applied to analyze the data.ResultsThere were no significant differences in long-term survival rates between patients who underwent NSM and those who underwent BCS+radiotherapy (BCS+RT), as indicated by the lack of significant differences in overall survival (OS) (p = 0.566) and breast cancer-specific survival (BCSS) (p = 0.431). Cox regression indicated that NSM and BCS+RT had comparable prognostic values (p = 0.286) after adjusting for other clinicopathological characteristics. For OS and BCSS, subgroup analysis showed that the majority of patients achieved an analogous prognosis whether they underwent NSM or BCS. The groups had comparable recurrence-free survival (RFS), with no significant difference found (p = 0.873).ConclusionsThis study offers valuable insights into the long-term safety and comparative effectiveness of NSM and BCS in the treatment of breast cancer. These findings can assist clinicians in making informed decisions on a case-by-case basis.

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Postoperative Complications from Breast and Axillary Surgery

Cited by 6 publications

References 126 publications

Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis

Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis

Adverse effects in the management of breast cancer – recent studies

Comparative effectiveness of nipple-sparing mastectomy and breast-conserving surgery on long-term prognosis in breast cancer

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