Postoperative Cardiac Support with a Pulsatile Assist Pump: Techniques and Results

Pierce, William S.; Rosenberg, Gerson; Donachy, James H.; Landis, D. L.; Weiss, Jason; Hensley, Frederick A.; Larach, David R.

doi:10.1111/j.1525-1594.1987.tb02666.x

Cited by 14 publications

(3 citation statements)

References 6 publications

(4 reference statements)

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“…1 The pump uses a segmented poly(ether polyurethane urea) blood sac and diaphragm. The dynamic stroke volume ranges from approximately 10 to 15 ml, depending on valve type and operating conditions.…”

mentioning

confidence: 99%

Energy Equivalent Pressure and Total Hemodynamic Energy Associated with the Pressure-Flow Waveforms of a Pediatric Pulsatile Ventricular Assist Device

Weiss

Lukic

Ündar³

2005

ASAIO Journal

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A pulsatile pediatric ventricular assist device (VAD) with a dynamic stroke volume of approximately 12 ml was tested to quantify the effect of flowrate and systolic duration on pulsatility as quantified by the energy equivalent pressure (EEP), defined as the hemodynamic energy per unit volume of fluid pumped. The VAD was tested on a mock circulatory loop, adjusted to maintain a systemic arterial pressure of approximately 90/60 mm Hg (systolic/diastolic) and a mean of 75 mm Hg. The EEP was calculated for each beat for 1 minute at both the proximal end of the pump outlet cannula and at the distal end (arterial EEP). Nominal mean flowrates were 0.50, 0.75, 1.00, and 1.25 l/min. Systolic duration was set at either 230 or 400 milliseconds. With a rapid systolic ejection (230 milliseconds), the arterial EEP ranged from 5.58% to 8.41% relative to the mean arterial pressure. The highest EEP occurred at the lowest flowrate. With a slower (400 milliseconds) systolic ejection, the arterial EEP ranged from 2.33% to 4.20%. Hemodynamic energy loss in the outlet cannula was also quantified by the differential EEP and shown to increase markedly as systolic duration was decreased, but was relatively insensitive to mean flowrate.

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mentioning

confidence: 99%

Energy Equivalent Pressure and Total Hemodynamic Energy Associated with the Pressure-Flow Waveforms of a Pediatric Pulsatile Ventricular Assist Device

Weiss

Lukic

Ündar³

2005

ASAIO Journal

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“…The design is based on the adult Thoratec® PVAD™ which was developed at Penn State as the Pierce-Donachy VAD 7 . The Infant VAD utilizes 17mm Björk-Shiley monostrut (BSM) Delrin disk valves with mounting flanges that are custom designed to fit this pump, and which are manufactured in house.…”

Section: Methodsmentioning

confidence: 99%

Chronic In Vivo Testing of the Penn State Infant Ventricular Assist Device

et al. 2012

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The Penn State Infant Ventricular Assist Device is a 12-14 ml stroke volume pneumatically actuated pump, with custom Björk-Shiley monostrut valves, developed under the National Heart, Lung, and Blood Institute (NHLBI) Pediatric Circulatory Support program. In this report we describe the 7 most recent chronic animal studies of the Infant VAD in the juvenile ovine model, with a mean body weight of 23.5 +/- 4.1 kg. The goal of 4-6 weeks survival was achieved in 5 of 7 studies, with support duration ranging from 5 to 41 days; mean 26.1 days. Anticoagulation was accomplished using unfractionated heparin, and study animals were divided into 2 protocol groups: the first based on a target activated partial thromboplastin time of 1.5 to 2 times normal, and a second group using a target thromboelastography R-time of 2 times normal. The second group required significantly less heparin, which was verified by barely detectable heparin activity (anti-Xa). In both groups, there was no evidence of thromboembolism except in one animal with a chronic infection and fever. Device thrombi were minimal, and were further reduced by introduction of the custom valve. These results are consistent with results of adult VAD testing in animals, and are encouraging given the extremely low levels of anticoagulation in the second group.

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“…35 The PVAD, which underwent initial development in 1986 under the direction of William S. Pierce, MD, in collaboration with 3M Corporation, is intended to be used for left, right, or biventricular support for up to 6 months. The device is intended primarily for paracorporeal placement (Figure 7) but will also be implantable for bridge-to-transplantation applications.…”

Section: Pediatric Ventricular Assist Device (Penn State)mentioning

confidence: 99%

The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program

et al. 2006

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Abstract-Options for the circulatory support of pediatric patients under the age of 5 years are currently limited to short-term extracorporeal devices, the use of which is often complicated by infection, bleeding, and thromboembolism. Recognizing this void, the National Heart, Lung, and Blood Institute solicited proposals for the development of novel circulatory support systems for infants and children from 2 to 25 kg with congenital or acquired cardiovascular disease. Five contracts were awarded to develop a family of devices that includes (1) an implantable mixed-flow ventricular assist device designed specifically for patients up to 2 years of age, (2) another mixed-flow ventricular assist device that can be implanted intravascularly or extravascularly depending on patient size, (3) compact integrated pediatric cardiopulmonary assist systems, (4) apically implanted axial-flow ventricular assist devices, and (5)

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Postoperative Cardiac Support with a Pulsatile Assist Pump: Techniques and Results

Cited by 14 publications

References 6 publications

Energy Equivalent Pressure and Total Hemodynamic Energy Associated with the Pressure-Flow Waveforms of a Pediatric Pulsatile Ventricular Assist Device

Energy Equivalent Pressure and Total Hemodynamic Energy Associated with the Pressure-Flow Waveforms of a Pediatric Pulsatile Ventricular Assist Device

Chronic In Vivo Testing of the Penn State Infant Ventricular Assist Device

The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program

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