Postoperative Antibiotics Correlate with Worse Outcomes after Appendectomy for Nonperforated Appendicitis

Postoperative Use of Antibiotics in Adults with Non-perforated Appendicitis Subjected to Open Appendectomy

“…The patients received postoperative antibiotics presented for re-evaluation of these antibioticassociated morbidities, which contributed to the elevated rate of readmissions (5.4% vs 1.7%, P = 0.08) with significantly prolonged postoperative length of hospital stay (2.6 vs 1.4 days, P= 0.001). This coincide with the study of Coakley et al [8] who showed that; in non-perforated appendectomy, the addition of post-operative antibiotics not only failed to add any benefit, but also worsened post-operative morbidity which contributed to the elevated rate of readmissions with prolonged hospital stay and increase in antibiotic-associated diarrhea and treatment cost. Also Bader HS and Hamza AS [20] concluded in their study that; the postoperative broad spectrum antibiotics added financial burden and side effects and had no effect towards preventing wound infection.…”

“…Subjected to Open Appendectomy Some adverse events are also associated with postoperative antibiotic use like clostridium difficile infection, bacterial resistance and postoperative diarrhea, prolonged hospital stay, increase in financial burden. Many recent researches support the use of single dose preoperative antibiotics in non-perforated appendicitis [8,9].…”

Metronidazole in Acute Non-perforated Appendicitis

“…15 Rate of infection greatly depends on the severity of appendicular inflammation or perforation and also on the use of appropriate antibiotics. The role of preoperative antibiotics in surgical prophylaxis is clearly defined.…”

“…[7][8][9][10][11][12] Disease process at the time of operation and the use of appropriate prophylactic antibiotics significantly affects the risk for postoperative surgical site infections in addition to patient's factors. 8,12 .…”

Wound infection in non-perforated acute appendicitis- single dose preoperative antibiotics vs. prophylactic postoperative antibiotics: does it make any difference?

“…8 Some adverse events are also associated with postoperative antibiotic use like prolonged hospital stay, increase in financial burden, clostridium difficile infection and postoperative diarrhea. 9 And many recent research data supports the use of single dose preoperative antibiotics in non-perforated appendicitis. 10 Patients undergoing open appendectomy often remain in hospital for 3-5 days after operation.…”