Wound infection in non-perforated acute appendicitis- single dose preoperative antibiotics vs. prophylactic postoperative antibiotics: does it make any difference?

Shirah, Bader; Shirah, Hamza Asaad

doi:10.18203/2320-6012.ijrms20160035

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…the single-dose (6.5%) & the multiple dose antibiotic prophylaxis group (6.4%) and the group who used antibiotics for five days postoperatively (3.5%). 9 One reason to this difference in SSI rate could be type antibiotic used for prophylaxis. We used co-amoxiclav, while cefuroxime was used in Mui, et al 5…”

Section: Discussion Discussionmentioning

confidence: 99%

“…Kasatpibal, et al 8 collected data of appendectomies from eight hospitals of Thailand from July 1, 2003 to June 30, 2004 and found 26 (1.22%) cases with SSI. Shira, et al 9 from Madina city in Saudi Arabia reported for the period from January 2010 to December 2014 similar rate of SSI following NPA in patients who received only preoperative antibiotics and the patients who received both preoperative plus three doses of same antibiotics postoperatively. Tiono, et al 10 from Bali, Indonesia from April to June 2012 showed similar results for risk of SSI among single-dose and multiple-dose antibiotic prophylaxis in NPA.…”

Section: Introduction Introductionmentioning

confidence: 91%

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Post-Operative Oral Antibiotics in Reducing Frequency of Surgical Site Infection Following Non-Perforated Appendectomy in Population of South Waziristan Agency, Pakistan

Alam¹,

Rehman

Waheed³

et al. 2021

GJMS

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Background: Acute appendicitis is most frequent cause of acute abdomen in younger population, and surgical site infection (SSI) is commonest complication of appendectomy. The objective of this trial was to compare the efficacy of post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.Materials Methods: The randomized placebo trial was conducted at Agency Headquarter Hospital, Wana, South Waziristan, Pakistan from October 1, 2016 to November 18, 2018. One hundred fifty (150) patients were randomly allocated into two groups, 75 in experimental group, to whom antibiotics were given and 75 in placebo group, to whom antibiotics were not given. Age groups and presence of SSI were two variables, being on nominal scale, were described by count and percentage with CI at 80%CL. McNemar chi-square test was applied to test the hypothesis to see the significance of difference between the experimental and placebo groups in terms of frequency of SSI at alpha .05.Results: SSI was present in nine (12%, 80%CI 7.19-16.80%) out of 75 cases in experimental group and in 12 (16%, 80%CI 10.57-21.42%) out of 75 cases in placebo group. McNemar chi-square test showed no significant difference between the experimental and placebo groups in terms of frequency of SSI (p=.2482).Conclusion: The results are comparable for post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.

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Section: Discussion Discussionmentioning

confidence: 99%

Section: Introduction Introductionmentioning

confidence: 91%

Post-Operative Oral Antibiotics in Reducing Frequency of Surgical Site Infection Following Non-Perforated Appendectomy in Population of South Waziristan Agency, Pakistan

Alam¹,

Rehman

Waheed³

et al. 2021

GJMS

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The role of preoperative graded compression ultrasound in detecting acute appendicitis and influencing the negative appendectomy rate

Shirah

Shirah²,

Alhaidari³

et al. 2016

Abdom Radiol

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Graded compression technique of ultrasound is a useful modality, in addition to the clinical judgment of the surgeon and clinical findings, in detecting true positive cases of acute appendicitis, and thus reducing the negative appendectomy rate. Values of 100% specificity, and 8.4% negative appendectomy rate, or better, could be achieved, when an experienced surgeon and a professional radiologist collaborate in the diagnosis of acute appendicitis.

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A Randomised Control Trial to Ascertain if Postoperative Antibiotics Are Necessary Following Laparoscopic Appendicectomy in Nonperforated Appendicitis

Meena

2023

Global Journal for Research Analysis

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Background: The most frequent cause of severe abdominal discomfort is acute appendicitis. Prophylactic antibiotics should be used as directed to reduce the risk of postoperative surgical site infections (SSIs). There is no denitive recommendation, though, for how long to use antibiotics. There has only been one preoperative prophylactic dose several randomised control trials strongly suggest. Therefore, the goal of the study was to ascertain if postoperative antibiotics were necessary following laparoscopic appendix surgery for nonperforated appendicitis. Methods: A total of 52 nonperforated appendicitis patients were separated into two groups and underwent laparoscopic appendectomy. Patients in group B (n=26) received three postoperative doses of antibiotics in addition to the one preoperative dose given to group A's (n=26) patients. Regular investigations, such as Complete blood count, blood urea, serum creatinine, and other tests like an abdominal ultrasound were also carried out. After a laparoscopic appendicectomy, the surgical incision was examined to check for any evidence of postoperative SSI after 48, 72, and 7 days. Results: Group A had a mean age of 30.6± 10.5 years compared to group B's mean age of 30.7 ±9.5 years (p=0.75). Right iliac fossa pain was the initial complaint of every subject in the research. Grade III SSIs occurred in 0ne patient in group A (4%) and one patient in group B (4%) and were treated conservatively. The difference in the incidence of SSIs between the two groups was statistically negligible (p=1.000). Conclusions: After a laparoscopic appendicectomy, prophylactic postoperative doses of antibiotics offer no additional advantage over a single preoperative dosage in terms of preventing postoperative SSIs

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Wound infection in non-perforated acute appendicitis- single dose preoperative antibiotics vs. prophylactic postoperative antibiotics: does it make any difference?

Cited by 3 publications

References 15 publications

Post-Operative Oral Antibiotics in Reducing Frequency of Surgical Site Infection Following Non-Perforated Appendectomy in Population of South Waziristan Agency, Pakistan

Post-Operative Oral Antibiotics in Reducing Frequency of Surgical Site Infection Following Non-Perforated Appendectomy in Population of South Waziristan Agency, Pakistan

The role of preoperative graded compression ultrasound in detecting acute appendicitis and influencing the negative appendectomy rate

A Randomised Control Trial to Ascertain if Postoperative Antibiotics Are Necessary Following Laparoscopic Appendicectomy in Nonperforated Appendicitis

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