Postnatal Nutritional Deprivations as Determinants of Adult Rat Behavior toward Food, Its Consumption and Utilization

Rh, Barnes; Cs, Neely; Kwong, Eva; Ba, Labadan; Franková, S

doi:10.1093/jn/96.4.467

Cited by 84 publications

(33 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IR rats, on the other hand, were much leaner than the controls, and in this they resemble adult rats which have been growthretarded from birth to weaning [26] or from birth to 7 postnatal weeks [3]. Nevertheless, the IR rats' body weight deficit cannot all be accounted for in terms of fat.…”

Section: Discussionmentioning

confidence: 84%

Further Studies of Body Growth and Brain Development in ‘Small-for-Dates’ Rats

Smart¹,

Adlard²,

Dobbing³

1974

Neonatology

View full text Add to dashboard Cite

Rats were growth-retarded either from conception to 5 postnatal days (FNR or ‘small-for-dates’ group) or from 5 to 25 postnatal days (IR group) by underfeeding their mothers or foster-mothers. All young were fed ad libitum from weaning till they were killed at 15–24 weeks. The body weight of the FNR rats was 36% less than that of controls at 5 days and remained significantly less throughout their lives. Their adult nose-rump and tail lengths were slightly but significantly shorter than those of controls, but they did not differ in total body fat. TR rats weighed less than control and FNR rats from 10 days onwards, and they were leaner than both groups at death. They grew more in nose-rump and tail length between 35 and 115 days than the other groups, but were still significantly shorter than the controls at 115 days. This ‘catch-up’ may be related to their relative skeletal immaturity (assessed radiographically) at the time of the body growth spurt. Brain growth was impaired in both FNR and IR rats, though in different ways. Cerebellar growth was selectively affected in IR but not in FNR rats. Total synaptosomal protein (a probable measure of synapse number) was lower in the brains of both experimental groups in proportion to their brain weight deficits.

show abstract

Section: Discussionmentioning

confidence: 84%

Further Studies of Body Growth and Brain Development in ‘Small-for-Dates’ Rats

Smart¹,

Adlard²,

Dobbing³

1974

Neonatology

View full text Add to dashboard Cite

show abstract

“…The dams and pups were placed in wooden cages (30 x 30 x 15 cm) and randomly assigned to receive ad lib either an 8 or a 25% casein diet. The two diets were isocaloric and prepared according to Barnes et al (Barnes, Neely, Kwong, Labadan, & Frankova, 1968). The protein-deficient diet contained 8% casein, 5% salt mixture, 1% vitamins mixture, 8% corn oil, 0.2% choline, and 77.8% cornstarch.…”

Section: Methods Animalsmentioning

confidence: 99%

Effects of Early Protein Malnutrition and Repeated Testing Upon Locomotor and Exploratory Behaviors in the Elevated Plus-Maze

Almeida

Garcia²,

Oliveira³

2016

REBAC

View full text Add to dashboard Cite

An elevated plus-maze was used to investigate the effects of repeated testing on the locomotor and exploratory behaviors of malnourished rats. Pup malnutrition was induced during the lactation period (0 to 21 days of age) by feeding the dams a protein-deficient diet (6% protein) and the animals were allowed to recover from weaning to 70 days of age by eating a commercial lab chow diet. Control animals were suckled by dams receiving normal protein diet (16% protein) during the lactation period and were fed a commercial lab chow diet after weaning. At 70 days, malnourished and control animals were placed on the central platform of the elevated plus-maze facing an enclosed arm and allowed to explore for 5 min. This procedure was repeated at 24-h intervals of 6 days. The repeated testing in the elevated plus-maze did not change the total number of arm entries and attempts to enter open arms, but decreased the percentage of open arm entries, time spent in open arms, and total time spent on the central platform. These data suggest an increase in anxiety with repeated testing in the elevated plus-maze. In addition, the malnourished animals showed a large number of these animals as compared to control. The elevated plus-maze proved to be useful animal model to evaluate exploratory behaviors in early protein malnourished animals.

show abstract

“…The diets used were prepared and modified as previously described (Barnes et al, 1968;Santucci, Daud, Almeida, & De-Oliveira, 1994) and were based on the recommendations of the American Institute of Nutrition (AIN-93) and the Association of Offi cial Agriculture Chemists (AOAC; Reeves, Nielsen, & Fahey, 1993). The control diet consisted of 16% protein (casein), 69.8% cornstarch, 8% lipids (corn oil), 5% salt mixture, 1% vitamin mixture, .2% choline, and methionine (2g/kg casein).…”

Section: Animals and Dietmentioning

confidence: 99%

“…This model is particularly interesting to study the early malnutrition procedures, since no food reward is required, since food reward could be a confounding variable when testing animals malnourished in the beginning of life. In addition, any kind of food reward could serve as a visual and/or olfactory clue and, possibly, produce differentially motivated responses toward the food in malnourished animals (Barnes, Neely, Kwong, Labadan, & Franková, 1968).…”

mentioning

confidence: 99%

Effects of acute stress on learning and memory processes of malnourished rats

Vales¹,

Fukuda²,

Almeida³

2014

Psicol. Reflex. Crit.

View full text Add to dashboard Cite

Abstr actThe aim of the study was to investigate the effects of acute stress on the processes of learning and memory in malnourished rats tested in the Morris water maze. The animals were divided into eight groups according to nutritional status (malnourished or well nourished) and stress (stressed or unstressed). In Experiment I the animals were subjected to immobilization stress procedure before the learning session and in Experiment II after the learning sessions. The test consisted of two daily sessions, and a memory test after four weeks. There was loss of learning and memory in malnourished rats. In Experiment I the malnourished group was positively affected by acute stress, with signifi cant improvement of performance. No effects of stress on the animals' performance in Experiment II were observed. In the memory test, the malnourished rats showed defi cits in consolidation and recall, regardless of the occurrence of stress. The stress imposed 24 hours before the learning task improved performance of malnourished animals with a protective effect of stress. However there was no improvement in the processes of retention or recall from memory (previously learned information) assessed four weeks later, during the memory retention test. Keywords: Protein malnutrition, acute stress, learning, spatial memory. ResumoO objetivo do estudo foi investigar os efeitos do estresse agudo sobre os processos de aprendizagem e memória em ratos desnutridos testados no labirinto aquático de Morris. Os animais foram divididos em oito grupos de acordo com a condição nutricional (desnutridos ou bem nutridos) e estresse (não estressados ou estressados). No Experimento I os animais foram submetidos ao procedimento de estresse por imobilização antes da sessão de aprendizagem e no Experimento II após as sessões de aprendizagem. O teste consistiu de duas sessões diárias e um teste de memória após quatro semanas. Houve prejuízos de aprendizagem e memória em ratos desnutridos. No Experimento I o grupo desnutrido foi positivamente afetado pelo estresse agudo, apresentando melhora signifi cativa de desempenho. Não foram observados efeitos do estresse sobre o desempenho dos animais no Experimento II. No teste de memória os ratos desnutridos apresentaram défi cits de consolidação e evocação, independentemente da ocorrência de estresse. O estresse imposto 24 horas antes da tarefa de aprendizagem melhorou o desempenho de animais desnutridos com um efeito protetor do estresse. Entretanto não houve melhora nos processos de retenção ou evocação da memória (informações previamente aprendidas), avaliados quatro semanas mais tarde, durante o teste de retenção de memória. Palavras-chave: Desnutrição proteica, estresse agudo, aprendizagem e memória espacial. Mailing address:

show abstract

Postnatal Nutritional Deprivations as Determinants of Adult Rat Behavior toward Food, Its Consumption and Utilization

Cited by 84 publications

References 11 publications

Further Studies of Body Growth and Brain Development in ‘Small-for-Dates’ Rats

Further Studies of Body Growth and Brain Development in ‘Small-for-Dates’ Rats

Effects of Early Protein Malnutrition and Repeated Testing Upon Locomotor and Exploratory Behaviors in the Elevated Plus-Maze

Effects of acute stress on learning and memory processes of malnourished rats

Contact Info

Product

Resources

About