2023
DOI: 10.3389/fnut.2023.1134955
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Postnatal nutrition environment reprograms renal DNA methylation patterns in offspring of maternal protein-restricted stroke-prone spontaneously hypertensive rats

Abstract: Maternal malnutrition hampers the offspring health by manipulating the epigenome. Recent studies indicate that the changes in DNA methylation could be reversed by afterbirth nutrition supplementation. In this study, we used DNA methylation arrays to comprehensively investigate the DNA methylation status of the renal promoter regions and the effects of postnatal protein intake on DNA methylation. We fed stroke-prone spontaneously hypertensive (SHRSP) rat dams a normal diet or a low-protein diet during pregnancy… Show more

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Cited by 2 publications
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“…As offspring DNA methylation can be modified, this opens opportunities for targeted therapies to reverse these epigenetic abnormalities. Indeed, it has been shown in strokeprone spontaneously hypertensive rats that a postnatal high-protein diet can reverse early changes in DNA methylation in offspring due to maternal protein restriction [116]. Collectively, this stresses the important role of DNA methylation in developmental programming due to adverse maternal nutrition.…”
Section: Dna Methylationmentioning
confidence: 99%
“…As offspring DNA methylation can be modified, this opens opportunities for targeted therapies to reverse these epigenetic abnormalities. Indeed, it has been shown in strokeprone spontaneously hypertensive rats that a postnatal high-protein diet can reverse early changes in DNA methylation in offspring due to maternal protein restriction [116]. Collectively, this stresses the important role of DNA methylation in developmental programming due to adverse maternal nutrition.…”
Section: Dna Methylationmentioning
confidence: 99%