Postnatal exposure of the male mouse to 2,2′,3,3′,4,4′,5,5′,6,6′-decabrominated diphenyl ether: Decreased epididymal sperm functions without alterations in DNA content and histology in testis

Assessing reproductive and endocrine parameters in male largescale suckers (Catostomus macrocheilus) along a contaminant gradient in the lower Columbia River, USA

“…Reductions in the percentages of normal sperm morphology have been related to high sperm chromatin fragmentation and lower motility (Spano et al, 1999). Consistent with this study with LSS showing no correlation between any BDE congeners and abnormal sperm morphologies, BDE-99 and BDE-209 administered to rodents did not result in abnormal morphologies (Kuriyama et al, 2005;Tseng et al, 2006).…”

“…The bacterial contamination that inflated 2009 values (Table 1) was arrested by using streptomycin in the shipping buffer in 2010 (Appendix B). Similarly, sperm counts were not affected in mice and humans that were exposed to PBDE (Tseng et al, 2006;Abdelouahab et al, 2011). In our study with LSS, BDE-99 was positively correlated with sperm counts and with total motility (Table 3), with T4 being negatively correlated with sperm counts and positively correlated with total motility (Table 5).…”

“…Sperm motility and MMP were decreased after zebrafish were exposed long-term to BDE-209 (He et al, 2011). A reduction in sperm MMP and an increase in intracellular H 2 O 2 were seen in adult male mice that had neonatal exposure to BDE-209, indicating a toxic mechanism of oxidative stress (Tseng et al, 2006).…”

PBDE flame retardants

“…228,229 Several OH-BDEs have also been found to bind with the estrogen receptor (ER) with the general trend that para-OH metabolites displayed the highest affinity for ERs with the lower OH-BDEs (1-4 bromines) tending to act as weak agonists while higher OH-BDEs (4 bromines or more) had antagonistic properties. 189,230,231 In addition, rodent studies [232][233][234][235][236] and cell-based assays 187,237 have shown that some PBDEs (PentaBDE, BDE-47, -99, -100, and -209) may be estrogenic and/or induce feminization in male animals by anti-androgenic pathways. In humans, epidemiology studies have measured PBDE associations with: cryptorchidism 238 ; early onset of menarche 239 ; decreased testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) in adult men 151 ; increased E2 in 3-mo old boys (BDE-154) 240 ; and decreased sperm counts and testis size in young adults (BDE-153).…”

Toxicokinetics and the related metabolites in rainbow trout (Oncorhynchus mykiss) after exposure to decabromodiphenyl ether

“…It is believed that PBDEs (mainly tetra-to octa-BDEs) are chemically and biologically persistent and lipophilic, and can be accumulated in fatty tissues of organisms. Some of these BDE congeners are even more toxic for animals, causing reproductive and developmental effects, neurobehavioral toxicity, thyroid hormone disruption, immune-toxicity and possibly cancer [2][3][4]. A mixture of penta-and octa-BDE has been banned for production and application in Europe (EU) and in other countries, whereas commercial deca-BDE (BDE209) is restricted to be used in electronic devices in the EU because deca-BDE coexists with other PBDEs, notably nona-BDE.…”