Postnatal Development of the Human Hippocampal Formation

Insausti, Ricardo; Cebada‐Sánchez, Sandra; Marcos, Pilar

doi:10.1007/978-3-642-03661-3

Cited by 66 publications

(87 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Third, as previous studies disagree with respect to whether adolescent memory development is associated with hippocampal or prefrontal cortical maturation [24,25], future studies should also analyze prefrontal cortical regions. Finally, biological interpretation of hippocampal subfield volumetric changes is complicated due to the myriad of possible contributing factors [75]. Postmortem data have demonstrated myelination in the DG and the subicular and presubicular regions throughout adolescence [76,77,78] and long-lasting neurogenesis in the DG [79,80,81], but it is not known how these and other processes affect MRI volumetry.…”

Section: Discussionmentioning

confidence: 99%

Regional Hippocampal Volumes and Development Predict Learning and Memory

et al. 2014

View full text Add to dashboard Cite

The hippocampus is an anatomically and functionally heterogeneous structure, but longitudinal studies of its regional development are scarce and it is not known whether protracted maturation of the hippocampus in adolescence is related to memory development. First, we investigated hippocampal subfield development using 170 longitudinally acquired brain magnetic resonance imaging scans from 85 participants aged 8-21 years. Hippocampal subfield volumes were estimated by the use of automated segmentation of 7 subfields, including the cornu ammonis (CA) sectors and the dentate gyrus (DG), while longitudinal subfield volumetric change was quantified using a nonlinear registration procedure. Second, associations between subfield volumes and change and verbal learning/memory across multiple retention intervals (5 min, 30 min and 1 week) were tested. It was hypothesized that short and intermediate memory would be more closely related to CA2-3/CA4-DG and extended, remote memory to CA1. Change rates were significantly different across hippocampal subfields, but nearly all subfields showed significant volume decreases over time throughout adolescence. Several subfield volumes were larger in the right hemisphere and in males, while for change rates there were no hemisphere or sex differences. Partly in support of the hypotheses, greater volume of CA1 and CA2-3 was related to recall and retention after an extended delay, while longitudinal reduction of CA2-3 and CA4-DG was related to learning. This suggests continued regional development of the hippocampus across adolescence and that volume and volume change in specific subfields differentially predict verbal learning and memory over different retention intervals, but future high-resolution studies are called for.

show abstract

Section: Discussionmentioning

confidence: 99%

Regional Hippocampal Volumes and Development Predict Learning and Memory

et al. 2014

View full text Add to dashboard Cite

show abstract

“…As previously described (Cebada-Sánchez et al, 2014;Coveñas et al, 2014), brains were immediately immersion-fixed in 10% formalin after dissection and then transferred to 4% paraformaldehyde in 0.1 M phosphate buffer-saline (PBS), pH 7.4, following the standardized protocol carried out in our Laboratory (Insausti et al, 2010). Brainstems were dissected out and cryoprotected in increasing sucrose solutions (15-30% in PBS) until they sank.…”

Section: Tissue Processingmentioning

confidence: 99%

Developmental study of vitamin C distribution in children's brainstems by immunohistochemistry

Coveñas

González-Fuentes

Infante

et al. 2015

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

“…These include studies of both the automatic (memory processes that may not be under conscious control; e.g., feature sampling) and strategic (memory processes that are under conscious control; e.g., semantic clustering of to-be-remembered information) aspects of memory (both at encoding and retrieval) and studies of changes in children's knowledge base [56][57][58][59][60][61][62][63] . Results have shown that dlPFC regions that mediate the encoding of detailed episodic representations of experiences may have a protracted period of development than the MTL 52, 56-63 (but see [64][65][66] , so that memory formation early in childhood depends more on MTL contributions 26,36,38,[67][68] . Speculation is that early reliance on the MTL may lead to sparser representations in memory, but as development proceeds, contributions from the PFC facilitates the encoding of more detail, especially detail that involves semantic processing 56,66,69 , but also storing greater contextual and source information 60 .…”

Section: Findings From Neurobiological Studiesmentioning

confidence: 99%