Postmortem Evidence of Structural Brain Changes in Schizophrenia

A continuum of psychosis, one human gene, and not much else — the case for homogeneity

“…(ii) Cortical mass (Zipursky et al, 1992;Ron et al, 1992) or brain size (Brown et al, 1986;Johnstone et al, 1989;Pakkenberg, 1987;Pearlson et al, 1989) is decreased.…”

The neurodevelopmental basis of sex differences in schizophrenia

“…Moreover, CT (Reveley et al 1987), MRI (Johnstone et al 1989a;Bogerts et al 1990ft;Suddath et al 1990), and neuropathological (Brown et al 1986;Crow et al 1989) studies have revealed structural anomalies of the left temporal lobe in some schizophrenics. The brain is, to an extent, capable of' compensating' for early unilateral brain damage.…”

Mutation and psychosis: a suggested explanation of seasonality of birth

“…It would be of interest to examine possible intergenerational trends at other points on the continuum, for example, between non-psychotic and psychotic affective disorder, between schizoaffective disorder and schizophrenia, and between schizophrenia without, and with, degrees of defect. The interpretation of such a trend, if it exists, is that an increase in the severity of psychosis not infrequently accompanies its transmission between generations and that this increase represents a change in the structure of the gene (Crow, 1986 c). According to the present viewpoint, such changes occur when transmission is through the male line.…”

“…For example, thinning of the parahippocampal gyrus relatively greater on the left side of the brain is described (Brown et al 1986), and an increase in dopamine content of the amygdala on the left but not on the right side is reported (Reynolds, 1983). Several authors (e.g.…”