Postmortem Chemistry of the Vitreous Body in Man

Naumann, Hans N.

doi:10.1001/archopht.1959.04220030012003

Cited by 83 publications

(69 citation statements)

References 17 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This results in further mobilisation of liver glycogen and release of glucose into the blood circulation as a counterbalancing phenomenon [18]. Due to the difficulty interpreting postmortem blood glucose levels, other fluids have been proposed as being more reliable in the estimation of antemortem blood glucose concentrations, particularly the cerebrospinal fluid and vitreous humor [19][20][21][22][23][24]. Investigation of the biochemical constituents of the vitreous humor have been periodically performed by several authors [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Is the formula of Traub still up to date in antemortem blood glucose level estimation?

et al. 2012

View full text Add to dashboard Cite

According to the hypothesis of Traub, also known as the 'formula of Traub', postmortem values of glucose and lactate found in the cerebrospinal fluid or vitreous humor are considered indicators of antemortem blood glucose levels. However, because the lactate concentration increases in the vitreous and cerebrospinal fluid after death, some authors postulated that using the sum value to estimate antemortem blood glucose levels could lead to an overestimation of the cases of glucose metabolic disorders with fatal outcomes, such as diabetic ketoacidosis. The aim of our study, performed on 470 consecutive forensic cases, was to ascertain the advantages of the sum value to estimate antemortem blood glucose concentrations and, consequently, to rule out fatal diabetic ketoacidosis as the cause of death. Other biochemical parameters, such as blood 3-beta-hydroxybutyrate, acetoacetate, acetone, glycated haemoglobin and urine glucose levels, were also determined. In addition, postmortem native CT scan, autopsy, histology, neuropathology and toxicology were performed to confirm diabetic ketoacidosis as the cause of death.According to our results, the sum value does not add any further information for the estimation of antemortem blood glucose concentration. The vitreous glucose concentration appears to be the most reliable marker to estimate antemortem hyperglycaemia and, along with the determination of other biochemical markers (such as blood acetone and 3-betahydroxybutyrate, urine glucose and glycated haemoglobin), to confirm diabetic ketoacidosis as the cause of death.

show abstract

Section: Discussionmentioning

confidence: 99%

Is the formula of Traub still up to date in antemortem blood glucose level estimation?

et al. 2012

View full text Add to dashboard Cite

show abstract

“…VH sodium levels of greater than 155 meq/L have been cited as evidence of dehydration [50]. Although changes occur in post-mortem sodium levels these often remain stable for sufficient time to provide information that may be useful in determining the mechanism of death [26] For example, the ante-mortem serum sodium and chloride concentrations are reflected in post-mortem vitreous values, making it possible to diagnose hyponatremia or hypernatremia at the time of death [1,6,13,14,16,[25][26][27][28]44,49,[51][52][53][54][55][56][57][58][59].…”

Section: Applications Electrolytesmentioning

confidence: 99%

“…Analysis of chemical changes within intraocular fluid, post-mortem, was introduced by Naumann [1] and has since generated great interest in the many applications of Vitreous Humor (VH) analysis [2].…”

Section: Introductionmentioning

confidence: 99%

Vitreous Humor: A Short Review on Post-mortem Applications

J¹

2015

J Clin Exp Pathol

View full text Add to dashboard Cite

Vitreous humor has been investigated since the 1960s, with many debates occurring over the years with regard to the usefulness of its specific applications. The composition of several electrolytes in post-mortem vitreous humour has been extensively studied. Using the fluid for determining the cause of death has also become commonplace, including testing glucose levels of diabetic related deaths, as well as alcohol and drug related fatalities. The debate regarding the composition between two eyes of the same individual has been an issue in the past, but has since been resolved.

show abstract

“…Consequently, vitreous humor sampled after the injection of the contrast One of the first reports concerning forensic biochemistry was published in 1940 and focused on postmortem blood glucose determination [12]. In 1959, Naumann [13] published the first report on the chemical constituents of human vitreous humor. Before then, the understanding of these constituents was limited to animals and enucleated human eyes.…”

Section: Discussionmentioning

confidence: 99%

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

et al. 2012

View full text Add to dashboard Cite

a b s t r a c tPostmortem angiography is becoming increasingly essential in forensic pathology as an adjunct to con-ventional autopsy. Despite the numerous advantages of this technique, some questions have been raised regarding the influence of the contrast agent injected on the results of toxicological and biochemical anal-yses. The aim of this study was to investigate the effect of the injection of the contrast agent Angiofil Ò , mixed with paraffin oil, on the results of postmortem biochemical investigations performed on vitreous humor. Postmortem biochemical investigations were performed on vitreous samples collected from bodies that had undergone postmortem angiography (n = 50) and from a control group (n = 50). Two vit-reous samples were analyzed for each group and the results compared. Glucose, urea, creatinine, 3-b-hydroxybutyrate, sodium and chloride were tested. Different values were observed between the first and second samples in each group. However, these differences were not clinically relevant, suggesting that the injection of this contrast agent mixture does not modify the concentration of the analyzed sub-stances in the vitreous humor.

show abstract

Postmortem Chemistry of the Vitreous Body in Man

Cited by 83 publications

References 17 publications

Is the formula of Traub still up to date in antemortem blood glucose level estimation?

Is the formula of Traub still up to date in antemortem blood glucose level estimation?

Vitreous Humor: A Short Review on Post-mortem Applications

Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography

Contact Info

Product

Resources

About