Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill?

Lacerda, Marcus Vinícius Guimarães; Fragoso, Silvio C. P.; Alecrim, Maria G. C.; Alexandre, Márcia A. A.; Magalhães, Belisa Maria Lopes; Siqueira, André Machado; Ferreira, Luíz Carlos Lima; Araújo, José R.; Mourão, Maria Paula Gomes; Ferrer, M. Carmen Olivé; Castillo, Paola; Martín-Jaular, Lorena; Fernández-Becerra, Carmen; Portillo, Hernando del; Ordi, Jaume; Alonso, Pedro L.; Bassat, Quique

doi:10.1093/cid/cis615

Cited by 189 publications

(216 citation statements)

References 40 publications

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“…Os valores de HT, HB e do número de eritrócitos foram menores apenas nos indivíduos com alta carga parasitária, o que já é conhecido e descrito na literatura 17,23 . Sabe-se que o aumento da carga parasitária pode acarretar diminuição no número de GV, devido à ruptura dessas células durante os ciclos assexuados, ao sequestro de hemácias infectadas pelo baço e à formação de rosetas 27,28,29 .…”

Section: Discussionunclassified

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Costa

Tarragô

Garcia

et al. 2017

Revista Pan-Amazônica de Saúde

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Section: Discussionunclassified

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Costa

Tarragô

Garcia

et al. 2017

Revista Pan-Amazônica de Saúde

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“…Further, patients not surviving PQ therapy may often be presumed to have died as a consequence of malaria, as occurred in at least two cases reported from Brazil. 116,117 Primaquine therapy against relapse certainly has the potential to cause lethal hemolytic anemia, but the incidence of such events cannot be known in the absence of evidence gathered by deliberate and direct surveys. Primaquine is underused.…”

mentioning

confidence: 99%

Diagnosis and Treatment of Plasmodium vivax Malaria

Baird

Maguire

Price

2012

Advances in Parasitology

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“…Notwithstanding this benign reputation, over the last two to three decades, there have been multiple case studies of fatal vivax malaria [6,7]. More recently, hospital and outpatient surveillance systems have shown that P. vivax-associated mortality may be occurring with greater frequency than previously thought or reported [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Mortality attributable to Plasmodium vivax malaria: a clinical audit from Papua, Indonesia

Douglas

Pontororing²,

Lampah³

et al. 2014

BMC Medicine

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Background: Plasmodium vivax causes almost half of all malaria cases in Asia and is recognised as a significant cause of morbidity. In recent years it has been associated with severe and fatal disease. The extent to which P. vivax contributes to death is not known. Methods: To define the epidemiology of mortality attributable to vivax malaria in southern Papua, Indonesia, a retrospective clinical records-based audit was conducted of all deaths in patients with vivax malaria at a tertiary referral hospital. Results: Between January 2004 and September 2009, hospital surveillance identified 3,495 inpatients with P. vivax monoinfection and 65 (1.9%) patients who subsequently died. Charts for 54 of these 65 patients could be reviewed, 40 (74%) of whom had pure P. vivax infections on cross-checking. Using pre-defined conservative criteria, vivax malaria was the primary cause of death in 6 cases, a major contributor in 17 cases and a minor contributor in a further 13 cases. Extreme anaemia was the most common primary cause of death. Malnutrition, sepsis with respiratory and gastrointestinal manifestations, and chronic diseases were the commonest attributed causes of death for patients in the latter two categories. There were an estimated 293,763 cases of pure P. vivax infection in the community during the study period giving an overall minimum case fatality of 0.12 per 1,000 infections. The corresponding case fatality in hospitalised patients was 10.3 per 1,000 infections. Conclusions: Although uncommonly directly fatal, vivax malaria is an important indirect cause of death in southern Papua in patients with malnutrition, sepsis syndrome and chronic diseases, including HIV infection.

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Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill?

Abstract: In 13 of 17 deceased patients, P. vivax infection was the plausible cause of death. However, more studies are needed to understand pathogenesis related to severe disease.

Cited by 189 publications

References 40 publications

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Diagnosis and Treatment of Plasmodium vivax Malaria

Mortality attributable to Plasmodium vivax malaria: a clinical audit from Papua, Indonesia

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