Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Costa, Allyson Guimarães; Tarragô, Andréa Monteiro; Garcia, Nadja Pinto; Pimentel, João Paulo Diniz; Neves, Walter Luiz Lima; Melo, Giane Zupellari dos Santos; Heckmann, Maria Izabel Ovellar; Malheiro, Adriana

doi:10.5123/s2176-62232017000200002

Cited by 2 publications

(5 citation statements)

References 30 publications

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“…(21) In general, human patients infected with P. vivax tend to present a significantly lower lymphocyte counts. (22) However, our results agreed with other authors, such as Lacerda et al, (23) in which the mean lymphocyte count was elevated in 29.6% of P. vivax patients from Brazilian endemic area.…”

Section: Discussionsupporting

confidence: 93%

“…(8) Abnormalities in liver function have been reported in patients infected with different species of Plasmodium, generally without significant clinical complications. (22) In the present work, infected animals showed higher levels of ALT in analyses including all animals, in the analysis comparing infected and uninfected females, and also in mixed infections compared to single one. The low values of the total proteins in animals with mixed infection, when compared to the animals with only one Plasmodium species infection, reinforce the suggestion that the infection might cause insufficiency in the synthesis of proteins due to possible liver damage.…”

Section: Discussionsupporting

confidence: 56%

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Plasmodium infection and its association with biochemical and haematological parameters in free-living Alouatta guariba clamitans (Cabrera, 1940) (Primates: Atelidae) in Southern Brazil

Nunes

Alvarenga

Souza

et al. 2019

Mem. Inst. Oswaldo Cruz

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BACKGROUND The influence of Plasmodium spp. infection in the health of Southern brown howler monkey, Alouatta guariba clamitans, the main reservoir of malaria in the Atlantic Forest, is still unknown.OBJECTIVES The aim of this study was to investigate the positivity rate of Plasmodium infection in free-living howler monkeys in an Atlantic Forest fragment in Joinville/SC and to associate the infection with clinical, morphometrical, haematological and biochemical alterations.METHODS Molecular diagnosis of Plasmodium infection in the captured monkeys was performed by Nested-polymerase chain reaction (PCR) (18S rRNA and coxI). Haematological and biochemical parameters were compared among infected and uninfected monkeys; clinical and morphometrical parameters were also compared.FINDINGS The positivity rate of Plasmodium infection was 70% among forty captured animals, the highest reported for neotropical primates. None statistical differences were detected in the clinical parameters, and morphometric measures comparing infected and uninfected groups. The main significant alteration was the higher alanine aminotransferase (ALT) levels in infected compared to uninfected monkeys.MAIN CONCLUSIONS Therefore, Plasmodium infection in howler monkeys may causes haematological/biochemical alterations which might suggest hepatic impairment. Moreover, infection must be monitored for the eco-epidemiological surveillance of malaria in the Atlantic Forest and during primate conservation program that involves the animal movement, such as translocations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 56%

Plasmodium infection and its association with biochemical and haematological parameters in free-living Alouatta guariba clamitans (Cabrera, 1940) (Primates: Atelidae) in Southern Brazil

Nunes

Alvarenga

Souza

et al. 2019

Mem. Inst. Oswaldo Cruz

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“…According to the results of other studies, primary malaria infection was associated with a decrease in serum levels of leukocytes 33 , 34 . Leukopenia is observed at the beginning of malaria infection, with transient leukocytosis occurring during the febrile paroxysms, which are related to the parasitic burden 35 , 36 .…”

Section: Discussionmentioning

confidence: 86%

“…These results agree with those by Costa et al . 34 , who observed (in the Amazon region) higher levels of red blood cells in patients with non-severe acute P. vivax malaria than in controls. However, our study differs from others studies that have observed a decrease in red blood cell, hemoglobin, and hematocrit values in patients with malaria.…”

Section: Discussionmentioning

confidence: 98%

“…In patients with P. vivax malaria, it was observed that the greater the parasitemia and the time for the disease to develop, the lower the serum levels of platelets. Thrombocytopenia is a common pathogenic phenomenon in patients with malaria 34 , 41 , commonly occurring in the pathogenesis of malaria, especially P. vivax malaria 7 , 42 . Although the determinant mechanisms of the thrombocytopenia associated with P. vivax malaria are not well defined, it is believed that they may be related to coagulation disorders, antibody-mediated platelet destruction, platelet aggregation, oxidative stress, platelet sequestration in the spleen, and alterations in the bone marrow 43 , 44 .…”

Section: Discussionmentioning

confidence: 99%

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Association between vitamin D serum levels and clinical, laboratory, and parasitological parameters in patients with malaria from an endemic area of the Amazon

Setto

Libonati

Ventura

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Background: Some studies have suggested the importance of vitamin D [25(OH)D] in malaria clinical practice. The prevalence of 25(OH)D deficiency in the Amazon population is not well known, and there are few studies in patients with malaria. This study aimed to evaluate 25(OH)D serum levels in patients with malaria and determine their relationships with epidemiological, clinical, laboratory, and parasitemia data. Methods: An analytical cross-sectional study of 123 patients with malaria and 122 individuals without malaria was performed in Itaituba, Pará, Brazil, from January 2018 to October 2019, by evaluating sociodemographic, clinical-epidemiological, parasitological, and laboratory data and adopting a 5% significance level. Parametric tests (Student's t- test), non-parametric tests (Mann-Whitney U ), and Spearman’s correlation ([r s ], for non-parametric variables) were used according to the nature of the distribution of the variables. For the qualitative variables, Pearson's chi-square test, Fisher's exact test, and the G test were used. Spearman's correlation was used to compare the results of the 25(OH)D levels and blood counts performed among patients and the control group. Results: Malaria patients residing in a mining area had 25(OH)D serum levels that were significantly lower than those in the control group residing in the mining area, though both were within normal levels. Red blood cell counts had an inverse correlation with parasitemia ( Plasmodium falciparum ), and platelet levels had an inverse correlation with parasitemia ( Plasmodium vivax ). 25(OH)D deficiency was evidenced in Itaituba, in the state of Pará, which is an endemic area of malaria in the Amazon region.

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Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Cited by 2 publications

References 30 publications

Plasmodium infection and its association with biochemical and haematological parameters in free-living Alouatta guariba clamitans (Cabrera, 1940) (Primates: Atelidae) in Southern Brazil

Plasmodium infection and its association with biochemical and haematological parameters in free-living Alouatta guariba clamitans (Cabrera, 1940) (Primates: Atelidae) in Southern Brazil

Association between vitamin D serum levels and clinical, laboratory, and parasitological parameters in patients with malaria from an endemic area of the Amazon

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