Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps

Giordano, Giovanna; Gnetti, Letizia; Merisio, Carla; Melpignano, Mauro

doi:10.1016/j.maturitas.2006.08.002

Cited by 44 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previously published studies, advanced age (>60 years), menopausal status, HRT and AUB were observed to be risk factors for malignancy in women with EPs (4,7,(16)(17)(18)37). In the present study, an age of >60 years was significantly associated with the risk of malignant progression of EPs; however, none of the remaining clinical variables considered were found to demonstrate such an association.…”

Section: Discussioncontrasting

confidence: 60%

Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps

et al. 2016

View full text Add to dashboard Cite

Abstract. The aim of the present study was to determine the association between the thickness of preperitoneal fat (PFT), utilized as an indicator of visceral fat deposition, and the risk of premalignant and malignant changes of endometrial polyps (EPs) in overweight and obese women. Overweight and obese women who had undergone diagnostic outpatient hysteroscopy and subsequent endometrial polypectomy between January 2010 and May 2013 were analyzed. Each patient underwent a transabdominal ultrasound for the purpose of measuring the thickness of preperitoneal fat. A total of 146 overweight or obese women were analyzed. The overall incidence of malignant or premalignant lesions was 8.2%. Notably, 5 patients (3.4%) received a histopathological diagnosis of complex hyperplasia with atypia, while polyps harboring carcinoma were diagnosed in 7 cases (4.8%). A significantly increased PFT was observed in women exhibiting preneoplastic and neoplastic lesions, compared with women with benign EPs (mean ± SD, 23.2±3.7 vs. 15.9±8.3; P<0.01). Patient age of >60 years was significantly associated with malignant progression of EPs, while body mass index, menopausal status, arterial hypertension, diabetes, abnormal uterine bleeding, hormone replacement therapy and tamoxifen treatment demonstrated no significant association with the development of preneoplastic and neoplastic lesions of the endometrium. In a multivariate analysis, only PFT maintained a significant correlation with the diagnosis of preneoplastic and neoplastic lesions on EPs (odds ratio, 1.14; 95% confidence interval, 1.04-1.26). Ultrasound evaluation of PFT in overweight and obese women may be useful for the identification of a particularly high-risk subgroup of women. Therefore, regardless of symptoms or additional clinical variables, these particularly high-risk women require appropriate counseling and prompt surgical removal of EPs.

show abstract

Section: Discussioncontrasting

confidence: 60%

Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps

et al. 2016

View full text Add to dashboard Cite

show abstract

“…No consensus exists in the literature regarding such correlations. Some authors such as Savelli et al [5] and Giordano et al [26] found a correlation between hormone replacement therapy, obesity and malignancy, whereas Antunes et al [27] did not. Ben-Arie et al [9] found importance in the size of the polyp, but Hassa et al [25] did not.…”

Section: Discussionmentioning

confidence: 97%

Endometrial Polyps: Symptomatology, Menopausal Status and Malignancy

Golan¹,

Cohen-Sahar²,

Keidar³

et al. 2010

Gynecol Obstet Invest

View full text Add to dashboard Cite

Aims: To assess the frequency of premalignant and malignant endometrial polyps in symptomatic and asymptomatic women. Methods: Retrospective registration of 1,124 patients who underwent hysteroscopic resection of endometrial polyps. Patient characteristics included age, menopausal status, presence or absence of symptoms, and use of hormonal medication. Histological diagnoses and complications were also analyzed. Results: 641 (57%) of 1,124 women with endometrial polyps were postmenopausal and 483 (43%) premenopausal. Abnormal uterine bleeding was reported by 548 women: 226 (49%) postmenopausal and 322 (51%) premenopausal. 576 (51%) women were asymptomatic. There were 16 patients with malignancy or premalignant conditions among the symptomatic patients (2.7%) compared to 7 such patients among the asymptomatic patients (1.3%; p = 0.17). Pathologic evaluation disclosed 7 cases of malignancy and 4 cases of atypical hyperplasia among bleeding postmenopausal women (11/263, 4%) and 2 malignancies and 3 cases of hyperplasia with atypia among asymptomatic postmenopausal women (5/378, 1.3%). Conclusion: We found premalignancy and malignancy in each patient group – pre- and postmenopausal, as well as symptomatic and asymptomatic. We recommend removal of any verified endometrial polyp.

show abstract

“…In the uterus, a peculiar hormonal microenvironment may explain different pathologic conditions, both benign and malignant. The complex inter-relationships between adenomyosis, endometriosis, leiomyomata, endometrial hyperplasia and carcinoma arising in the endometrium or in adenomyosis have been illustrated together with their hormonal dependency [1,2,13], and factors like obesity and hormonal replacement therapy have been considered as relevant risk factors [13,14]. …”

Section: Resultsmentioning

confidence: 99%

Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report

et al. 2007

View full text Add to dashboard Cite

show abstract

Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps

Cited by 44 publications

References 21 publications

Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps

Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps

Endometrial Polyps: Symptomatology, Menopausal Status and Malignancy

Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report

Contact Info

Product

Resources

About