Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report

Puppa, Giacomo; Shozu, Makio; Perin, Tiziana; Nomura, Kohji; Gloghini, Annunziata; Campagnutta, E; Canzonieri, Vincenzo

doi:10.1186/1471-2407-7-103

Cited by 15 publications

(8 citation statements)

References 28 publications

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“…They reviewed 4 cases of their own patients and 26 previously reported cases of patients in 2002 with malignant neoplasm arising from adenomyosis (2). We found 9 additional cases of patients with malignant neoplasms arising from adenomyosis in English literature (3)(4)(5)(6)(7)(8)(9)(10)(11). Most of the malignant tumors arising The diagnostic criteria for ovarian carcinoma arising from endometriosis were originally proposed by Sampson (12) and modified by Colman and Rosenthal (13) so as to apply the criteria to carcinomas developing from adenomyosis as follows: a) the carcinoma should be absent in the normally situated endometrium and elsewhere in the pelvis; b) the carcinoma should be actually observed to be arising from the epithelium of the areas of adenomyosis and not invading it from some other source; and c) endometrial stromal cells should be surrounding the aberrant glands to support the diagnosis of adenomyosis.…”

Section: Discussionmentioning

confidence: 98%

Clear Cell Adenocarcinoma Arising From Adenomyosis

Hirabayashi

Yasuda²,

Kajiwara³

et al. 2009

International Journal of Gynecological Pathology

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A 73-year-old postmenopausal Japanese woman presented with a complaint of slight fever and weight loss. An elevated level of CA125 in the blood favored a diagnosis of malignant uterine body tumor, but was not confirmed by endometrial cytology and biopsy. Resection of the uterus revealed a solid whitish tumor in the myometrium that was diagnosed as clear cell adenocarcinoma (CCA) arising from adenomyosis. There were transitions between endometrial epithelium of adenomyosis, noninvasive CCA, and invasive CCA. Immunohistochemical expression of hepatocyte nuclear factor-1beta supported the diagnosis of CCA. Only one other English language document pertaining to CCA arising from adenomyosis exists. Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial.

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Section: Discussionmentioning

confidence: 98%

Clear Cell Adenocarcinoma Arising From Adenomyosis

Hirabayashi

Yasuda²,

Kajiwara³

et al. 2009

International Journal of Gynecological Pathology

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“…Features identified in these lesions include expression of oestrogen and progesterone receptors, cyclooxygenase-2, CA-125 and focal expression of aromatase [52], supporting the hypothesis of the existence of hyperplasia-cancer sequence in the ectopic endometrium. On the contrary, advanced poorly differentiated adenocarcinoma stained positively for p53, but not ER or PR [86].…”

Section: Adenomyosis In Patients With Endometrial Cancermentioning

confidence: 99%

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

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To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.

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“…On the other hand, the development of cancer from adenomyosis is a relatively rare occurrence. At present, only about 40 cases of malignant neoplasms arising from adenomyosis have been reported in English literature [2,3]. The most frequent histologic type of malignant neoplasm arising from adenomyosis is endometrioid adenocarcinoma.…”

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confidence: 99%

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Shin

Cho

Sung

et al. 2011

Korean J Obstet Gynecol

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The incidence of cancer from adenomyosis is rare. Previously, only two cases of clear cell adenocarcinoma (CCA) arising from adenomyosis have been reported in English literature. Here, we report a case of CCA arising from adenomyosis. A 52-year-old postmenopausal Korean woman presented with complaints of vaginal bleeding and back pain. Endometrial biopsy revealed endometrial polyp with atrophic change and transvaginal ultrasonography showed myomas with cystic change. Magnetic resonance imaging revealed a cystic degenerative mass consistent with leiomyoma in the posterior portion of uterus body. And the serum level of CA-125 was 17.7 U/mL. Hysterectomy revealed a yellow-ten solid mass in the myometrium that was diagnosed as CCA arising from adenomyosis. The tumor was mainly located in the myometrium and transition between adenomyosis and CCA along with endometrial stromal cell was identifi ed. Malignant tumor arising from adenomyosis could be considered as a differential diagnosis when the patient with adenomyosis and intact endometrial surface complained of vaginal bleeding.

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Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report

Abstract: Background: Malignant transformation of adenomyosis is a very rare event. Only about 30 cases of this occurrence have been documented till now.

Cited by 15 publications

References 28 publications

Clear Cell Adenocarcinoma Arising From Adenomyosis

Clear Cell Adenocarcinoma Arising From Adenomyosis

Adenomyosis and Endometrial Cancer: Literature Review

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

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