Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis

Atsma, Femke; Bartelink, Marie-Louise; Grobbee, Diederick E.; Schouw, Yvonne T. van der

doi:10.1097/01.gme.0000218683.97338.ea

Cited by 647 publications

(447 citation statements)

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“…In the same study, there was also evidence for a greater risk of CHD and stroke more than 1 year post menopause. However, these findings were in contrast to those in an Italian population 14 , which found no increased risk of myocardial infarction in post-menopausal women less than 10 years, 10-20 years and more than 20 years post menopause compared with pre-or peri-menopausal women.…”

Section: Years Since Menopause With Cvd Outcomes and Intermediate Carcontrasting

confidence: 99%

“…The findings of this systematic review on the risk of CVD associated with early menopause generally concur with and further extend a previous review 14 , which reported an increased risk of CVD for women at menopausal age of 50 years or younger compared with menopausal age ≥51 years. However, the findings of the previous review were based only on few prospective studies (7 prospective cohort studies) and therefore the authors were not able to compare other age categories with the risk of CVD.…”

Section: Interpretation Of Findingssupporting

confidence: 88%

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Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

et al. 2016

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Role of the Funder/Sponsor: Metagenics Inc. had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscript.The funder/sponsor did not have the ability to veto publication of study results. Data Extraction: Data were extracted by two independent reviewers using a pre-designed data collection form. Word count text: 3494 wordsMain outcomes and Measures: CVD outcomes (composite CVD, fatal and non-fatal coronary heart disease (CHD) and overall stroke and stroke mortality), CVD-mortality, all-cause mortality and intermediate CVD endpoints.Results: Out of initially identified references, 32 studies were selected, including 310,329 non-overlapping women. Women with a menopausal age of younger than 45 years compared to women with a menopausal age of 45 years or older, the relative risk (RR) [95% confidence intervals (CI)] was 1.50(1.28-1.76) for overall CHD, 1.11(1.03-1.20) for fatal CHD, 1.23 (0.98-1.53) for overall stroke, 0.99 (0.92-1.07) for stroke mortality, 1.19(1.08-1.31) for CVD mortality and 1.12(1.03-1.21) for all-cause mortality. For women with a menopausal age between 50-54 years compared to women with a menopausal age of younger than 50 years, there was a decreased risk of fatal CHD (RR:0.87(95%CI:0.80-0.96)), and no effect on stroke. Duration since menopause in relation to risk of developing intermediate cardiovascular traits or CVD outcomes was reported in 4 observational studies, reporting no consistent results. Conclusions and Relevance:The findings of this review indicate an excess CHD, CVD-mortality and overall mortality risk in women who have an early or premature menopause.

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Section: Years Since Menopause With Cvd Outcomes and Intermediate Carcontrasting

confidence: 99%

Section: Interpretation Of Findingssupporting

confidence: 88%

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

et al. 2016

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“…Exploring relationships between sedentary behaviour and symptoms may provide insight in the variety of body systems affected by sedentary behaviour. Mid aged women are a priority target group for such research, as transmenopausal changes can initiate an increase in incidence of chronic disease (Atsma et al, 2006;Meema and Meema, 1976).…”

Section: Introductionmentioning

confidence: 99%

Associations between sitting time and a range of symptoms in mid-age women

Peeters

Burton

Brown

2013

Preventive Medicine

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“…Em mulheres jovens com FOP, os benefícios da terapia de reposição hormonal geralmente superam os riscos potenciais (23). A ausência de reposição de estrogênio nas mulheres jovens pode ocasionar maior risco de doença cardíaca coronária tardia, possivelmente devido à deficiência de estrogênio (44)(45)(46)(47). Como um exemplo, dois estudos sugerem que as mulheres com FOP apresentam disfunção endotelial vascular significativa, a qual é restaurada ao normal por terapia com estrogênio (45,46).…”

Section: Duração Da Terapia Com Estrogêniounclassified

Falência ovariana precoce

Assumpção

2014

Arq Bras Endocrinol Metab

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RESUMOEste artigo irá rever os diversos aspectos da falência ovariana prematura (FOP), definida como o desenvolvimento de hipogonadismo em mulheres antes dos 40 anos, desde a etiopatogenia, com discussões sobre as causas autoimunes, iatrogênicas, ou anormalidades do cromossomo X assim como manifestações clínicas, diagnóstico e tratamento. A maioria das mulheres com essa condição não possui uma história menstrual, específica do desenvolvimento da FOP, mas a infertilidade associada ao diagnóstico é o aspecto mais problemático da doença. INTRODUÇÃO M uitas revisões recentes têm discutido o nome apropriado para essa condição, embora muitos pacientes e médicos prefiram o termo menopausa prematura, um termo simples e compreensível que pode ser explicado aos amigos e familiares, mas implica certa sensação de permanência, no entanto, a ovulação e a gravidez podem ocorrer em um momento posterior, por vezes anos após o diagnóstico (1-3).A falência ovariana precoce (FOP) é definida como falência gonadal antes dos 40 anos de idade. A incidência é de aproximadamente 1 em 250 mulheres com idade de 35 anos e de 1 em 100 com idade de 40 anos. É idiopática em 74% a 90% das pacientes. Algumas pacientes com FOP podem produzir estrogênio, ovular, e, em 5% a 10% dos casos, conceber e ter uma gravidez e parto sem alterações, assim como ter a função ovariana intermitente (sem amenorreia associada) e menstruação espontânea (embora anormalidades da função menstrual estejam presentes) (3-9).Neste artigo, o termo a ser utilizado será falência ovariana precoce (FOP), o qual é adequado e descreve seu diagnóstico. ETIOLOGIA E PATOGENIAEntender a causa da FOP exige uma compreensão do processo de foliculogênese em que muitas das molé-culas que regulam a série de eventos na maturação folicular estão envolvidas. O processo de maturação folicular ocorre de forma contínua e pode demorar até um ano para proceder o início do crescimento de um folículo primordial até se tornar um folículo ovulatório. A granulosa e as células somáticas da teca sintetizam e secretam fatores de crescimento e diferenciação, fatores de transcrição, como o FOXL2, inibina e hormônios esteroides que são regulados pelas http://dx

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Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis

Cited by 647 publications

References 43 publications

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

Associations between sitting time and a range of symptoms in mid-age women

Falência ovariana precoce

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