Postmenarche growth: cohort study among indigenous and non-indigenous Chilean adolescents

Amigo, Hugo; Lara, Macarena; Bustos, Patricia; Muñoz, Sergio

doi:10.1186/s12889-015-1389-y

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…To our knowledge, this is one of the few cohort health studies to have been conducted in an indigenous population in South America. Others include a growth study of indigenous and nonindigenous girls in Chile's Araucanía Region (Amigo, Lara, Bustos, & Muñoz, ; Amigo, Vásquez, Bustos, Ortiz, & Lara, ) and a 9‐year panel study carried out among the Tsimane' indigenous people in Bolivia to access the impact of modernization and market exposure on overall health, nutrition, and perception of wellbeing (Gurven et al, ; Leonard et al, ). In Brazil, an ongoing prospective birth cohort study addresses social determinants of child respiratory health among the Guarani Mbya (Cardoso et al, ).…”

Section: Introductionmentioning

confidence: 99%

The Xavante Longitudinal Health Study in Brazil: Objectives, design, and key results

Welch

Ferreira

Tavares

et al. 2019

American J Hum Biol

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Objective The Xavante Longitudinal Health Study was developed to permit granular tracking of contemporary health challenges faced by indigenous communities in Brazil, taking into consideration ongoing historical processes that may be associated with increases in child undernutrition, adult obesity, and cardiovascular disease risks. Methods This was an open‐cohort study with six semiannual data collection waves from 2009 to 2012. The study was undertaken in two Xavante villages, Pimentel Barbosa and Etênhiritipá, State of Mato Grosso, Central Brazil. No sampling technique was used. Data collection placed emphasis on growth and nutrition of children under five and nutrition status, blood pressure, and blood glucose levels of adolescents and adults. Results Baseline data collection began in July/August 2009 with a population census (656 individuals). Between the first and final waves, the study population increased by 17%. At baseline, stunting and wasting was elevated for most age groups <10 years. Overweight, obesity, and increased risk of metabolic complications were expressive among individuals >17 years, disproportionately affecting females. Anemia was elevated in most age groups, especially among females. Mean systolic and diastolic blood pressure was moderate. The overall prevalence of high blood pressure was relatively low. Conclusions Our findings reveal marked health disparities relative to the Brazilian national population and a complex dietary health epidemiology involving the double burden of malnutrition, rapidly changing nutritional indicators, and elevated metabolic disease risk. The topically broad multidisciplinary focus permitted construction of the richest longitudinal data set of socio‐epidemiological information for an indigenous population in Brazil.

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Section: Introductionmentioning

confidence: 99%

The Xavante Longitudinal Health Study in Brazil: Objectives, design, and key results

Welch

Ferreira

Tavares

et al. 2019

American J Hum Biol

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“…Evolución de la prevalencia de obesidad según origen étnico. tanto el IMC, la circunferencia de cintura y el porcentaje de grasa fueron mayores en las niñas indígenas, así como la frecuencia de exceso de peso (55% vs. 42%, respectivamente; p < 0,001) 23 . Respecto al crecimiento en estatura de estas cohortes, se comprobó que las niñas indígenas eran más bajas que las no indígenas en el momento de la menarquia, y que el aumento de estatura durante los 36 meses post menarquia fue también menor en las niñas indígenas.…”

Section: Figuraunclassified

Salud y nutrición del niño indígena chileno (Mapuche)

Amigo

Bustos

2019

Cad. Saúde Pública

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El objetivo de este trabajo fue realizar una revisión de la situación de salud y nutrición del niño indígena chileno, específicamente del Mapuche, en lo publicado en las bases de datos de referencias bibliográficas y en investigaciones específicas que tienen base poblacional. Para este trabajo se buscó lo publicado en PubMed, LILACS, organismos nacionales e internacionales, durante los últimos 15 años. Desde el 2006 hasta el 2015 la proporción de pobres era mayor en los indígenas, con disminución de la brecha de 16% el 2006 a 7,7% el 2015 (p < 0,001). En la primera década de este siglo la mortalidad infantil en los niños indígenas tenía una tasa de 17,1/1.000 nacidos vivos, mientras en los no indígenas era de de 8,8/1.000 y, en el seguimiento de cinco años, la brecha se mantuvo (p < 0,001). Los recién nacidos con peso < 2,500g el año 2000 no superaban el 6% (5,6% en no indígenas y 5,2% en los indígenas). La talla baja al ingreso a la escuela era 8,4% en los escolares indígenas y 3,1% en los no indígenas, disminuyendo a 3,7 en los indígenas y 2,6% en los no indígenas el 2004, la obesidad en cambio aumentó más en los indígenas, llegando a 24,2 y 25,3% en los no indígenas (p < 0,001). La menarquia se presentó cuatro meses más tarde en las indígenas (12,7 años) y el índice de masa corporal, circunferencia de cintura y el porcentaje de grasa, fueron significativamente mayores en las indígenas en el momento de la telarquia, así como la frecuencia de exceso de peso (55% vs. 42% en las no indígenas). Los niños Mapuche presentan una condición de salud y nutrición favorable, comparada con los indígenas de otros países del continente, sin embargo, aun existe una brecha adversa -comparada con los no indígenas-, en que la desigualdad desfavorece al niño indígena y esta debe ser reconocida y corregida.

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“…Also, while menarcheal age is > 13 years old in northeastern European girls, in Latin American populations like Chile [18] and Venezuela is ∼ 12.5 years old. A study performed among Mapuche Indigenous and non-Indigenous girls from the Araucanía region in Southern Chile showed that the age at menarche is 12.6 years in Mapuche girls, whereas it is 12.2 years in non-Indigenous girls (after correcting for socio-economic status) [19]. Further, Mapuche origin in Chile is an independent risk factor for precocious gonadarche (i.e.…”

Section: Introductionmentioning

confidence: 99%

Joint models reveal genetic architecture of transitions between pubertal stages and their association with BMI in a Latino population

Vicuña

Barrientos

Leiva-Yamaguchi

et al. 2023

Preprint

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Early or late pubertal onset can lead to disease in adulthood, including cancer, obesity, type 2 diabetes, metabolic disorders, bone fractures and psychopathologies. Thus, knowing the age at which puberty is attained is crucial as it can serve as a risk factor for future diseases. Pubertal development is divided into five stages of sexual maturation in boys and girls according to the standardized Tanner scale. We performed genome-wide association studies (GWAS) on the GOCS cohort composed of admixed children with European and Native American ancestry. Using joint models that integrate time-to-event survival parameters and longitudinal trajectories of body-mass index (BMI), we identified genetic variants associated with phenotypic transitions between pairs of Tanner stages. We identified 43 novel significant associations, most of them in boys. The GWAS on Tanner 3 → 4 transition in boys captured an association peak around the growth-related genes LARS2 and LIMD1 genes, the former of which causes ovarian dysfunction when mutated. The associated variants are expression— and splicing Quantitative Trait Loci regulating gene expression and alternative splicing in multiple tissues. Further, higher individual Native American genetic ancestry proportions predicted a significantly earlier arrival to Tanner 2 stage in boys but not in girls. Finally, the joint models identified longitudinal BMI parameters significantly associated in several Tanner stages transitions, confirming the association of BMI on pubertal timing.

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Postmenarche growth: cohort study among indigenous and non-indigenous Chilean adolescents

Cited by 8 publications

References 27 publications

The Xavante Longitudinal Health Study in Brazil: Objectives, design, and key results

The Xavante Longitudinal Health Study in Brazil: Objectives, design, and key results

Salud y nutrición del niño indígena chileno (Mapuche)

Joint models reveal genetic architecture of transitions between pubertal stages and their association with BMI in a Latino population

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