Aim: Comparison of two different radiation fractionation schedules is done in post mastectomy breast cancer cases in relation to loco regional control, acute and late toxicities, survival and overall treatment time (O.T.T). The patient, tumor and treatment related parameters have also been studied.
Materials and Methods:Between December 2011 and December 2013, hundred patients of stage II to III carcinoma breast treated with surgery and chemotherapy received adjuvant radiation therapy with two different fractionation regimes:• (Regimen-1, 50 patients) -42.5 Gray/16 fractions/3.1 weeks @ 2.6 Gray/ fraction (#)• (Regimen-2, 50 patients) -50 Gray/25 fractions/5 weeks @ 2 Gray/fraction (#)Assessment was done for loco regional and distant control rate, acute and late radiation toxicities, and quality of life related parameters.