Accelerated Hypofractionated Radiation in Carcinoma Breast

Alam, Md Shadab

doi:10.21767/2254-6081.100055

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…Kouloulias et al, (2016) reported grade 2-3 dermatitis at 29%, while Ko et al, (2015) reported grade 2 at 10.7% in HFRT. The present study found grade 2 at 42.2% in CFRT which is comparable to the results from Rastogi et al, (2018) and Alam et al, (2016). Cardiotoxicity is a late complication which significantly occurs in patients who receive left-sided radiotherapy (Sardar et al, 2017).…”

Section: Discussionsupporting

confidence: 85%

“…Rastogi et al, (2018) found grade 2 acute dermatitis 40% in CFRT and 42% in HFRT. Similarly, by Alam et al, (2016) that grade 2 were seen at 42% in CFRT and 54% in HFRT. Kouloulias et al, (2016) reported grade 2-3 dermatitis at 29%, while Ko et al, (2015) reported grade 2 at 10.7% in HFRT.…”

Section: Discussionmentioning

confidence: 82%

“…In addition, HFRT has been used in post mastectomy patients who require adjuvant radiotherapy, especially in the countries with limited radiotherapy resources, in order to decrease patient waiting time to start radiotherapy and increase patient turnover rate. There were many centers reported similar efficacy and toxicity of HFRT to CFRT (Pinitpatcharalert et al, 2011;Eldeeb et al, 2012;Alam et al, 2016;Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Treatment Outcome between Hypofractionated Radiotherapy and Conventional Radiotherapy in Postmastectomy Breast Cancer

Tovanabutra

Katanyoo

Uber

et al. 2020

Asian Pac J Cancer Prev

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Objective: The aim of this study was to compare Conventional fractionated radiotherapy (CFRT) and Hypofractionated radiotherapy (HFRT) in terms of treatment outcomes, such as in 5-year loco-regional recurrence free survival, disease free survival, overall survival, and distant metastatic free survival rates as well as toxicity. Materials and Methods: We retrospectively analyzed the data obtained from 462 breast cancer patients who received complete adjuvant radiotherapy treatment between January 2012 and December 2014. One hundred twenty eight patients received CFRT 2 Gy daily fractions at a total dose of 48-60 Gy (group 1), while 334 patients received HFRT 2.65-2.67 Gy daily for 15-19 fractions at a total dose of 39.7-47.8 Gy 9 (grup 2). Treatment outcome such as 5-year loco-regional recurrence free survival, disease free survival, overall survival, and distant metastatic free survival rates as well as toxicity were measured and compared between two groups. Results: Median follow-up was 65.7 months (ranging from 45.1 to 95.2 months). Five-year loco-regional recurrence free survival rate was 96.1% in both CFRT and HFRT groups (p=0.993). Five-year disease-free survival rate of CFRT group was higher (68.8%), but this difference was not significant (HFRT =63.5%) (p=0.396). These were complied with 5-year overall survival rate (71.9% and 64.7%, p=0.385). Five-year distant metastatic free survival rate was 85.9% in CFRT group and 79.6% in HFRT group (p=0.169). No difference was observed between two groups in terms of toxicities, including changes in chest wall appearance, skin fibrosis, brachial plexopathy, arm edema, pulmonary fibrosis, and cardiovascular events. Conclusion:The treatment outcomes of hypofractionated radiotherapy in the postmastectomy breast cancer patients is comparable to the outcomes of conventional treatment at the Chonburi Cancer Hospital as previously reported from other studies, and HFRT can be implemented in resource-limited settings.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Comparison of Treatment Outcome between Hypofractionated Radiotherapy and Conventional Radiotherapy in Postmastectomy Breast Cancer

Tovanabutra

Katanyoo

Uber

et al. 2020

Asian Pac J Cancer Prev

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“… 38 Additionally, a number of retrospective studies have reported that patients who received HF-PMRT experienced significantly lower or similar rates of acute skin toxicity compared with those who received SF-PMRT. 32 , 33 , 34 , 36 , 40 , 41 …”

Section: Methodsmentioning

confidence: 99%

Hypofractionated Postmastectomy Radiation Therapy

Sayan

Yehia

Ohri

et al. 2021

Advances in Radiation Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…31 Because shorter treatment regimens are more convenient and cost-effective, there is growing interest globally in applying hypofractionated treatments to patients requiring PMRT and/or RNI (Table 1). [32][33][34][35][36][37] The largest phase III trial to date comparing hypofractionated versus conventional PMRT was conducted in China. 36 More than 800 patients treated with mastectomy without reconstruction were randomly assigned to conventional (50 Gy in 25 fractions) or hypofractionated (43.5 Gy in 15 fractions) radiation to the chest wall, level III axillary nodes, and supraclavicular nodes, without treatment of IMNs.…”

Section: Survival and Pmrtmentioning

confidence: 99%