Postirradiation angiosarcoma of the head and neck: Report of a case

Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx

“…Postirradiation angiosarcoma of the head and neck has been reported by Grady et al 6 Here, an elderly woman received 70 Gy for recurrent lower lip squamous cell carcinoma and developed angiosarcoma 10 years later. Interestingly, this angiosarcoma was initially misdiagnosed as radiation-induced osteonecrosis.…”

Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review

“…On the other hand, in the group of patients aged older than 40 years, the mean age was 55.1 years (range 40-81) and a mean latency until appearance of the sarcoma of 9.6 years (range 1. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma

“…The global incidence of irradiation-associated sarcoma is estimated as between 0.03% and 0.08% [6]. Eleven cases of angiosarcoma of the head and neck were reviewed the mean age was determined to be 64 years; surgery was the primary method of treatment; 2-year survival rate was 50%; 5-year survival rate was 22%.…”

“…In the case report not only we present our patient definitively that is diagnosed with an angiosarcoma of the epiglottis, but also we have confirmation from our prior radiation records that the patient did, in fact, receive a substantial dose of radiation to the site previously. In order to attribute to prior radiation treatment as the causative factor the following classification has to be met: (i) the site of origin must be within the field of previous radiation; (ii) the patient should have received a significant amount of radiation therapy (greater than 2,500 rads); (iii) an interval of at least 3–5 years must elapse between the time of irradiation and the development of the sarcoma; (iv) the second primary cancer need is histologically different from the primary neoplasm (Table 3) [2, 6]. In the case of our patient: the epiglottis was included in the site of the prior radiation field encompassing the boost, the patient received 5,940 rads, an interval of 20 years had elapsed between her last cancer and the development of the angiosarcoma, and the primary cancer 20 years ago had been histologically identified as squamous cell carcinoma.…”