Postinflammatory hyperpigmentation: a common but troubling condition

Lacz, Nicole L.; Vafaie, Janet; Kihiczak, Nadia I.; Schwartz, Robert A.

doi:10.1111/j.1365-4632.2004.02267.x

Cited by 113 publications

(122 citation statements)

References 34 publications

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“…acne, eczema, and psoriasis) there is a risk of postinflammatory hyperpigmentation (PIH) due to excessive cytokine secretion [59]. As with melasma, PIH occurs more often in patients with darker skin, although there is no gender predominance.…”

Section: Induction Of Hyperpigmentation -Specific Mechanismsmentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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Rates of skin cancer continue to increase despite the improved use of traditional sunscreens to minimize damage from ultraviolet radiation. The public perception of tanned skin as being healthy and desirable, combined with the rising demand for treatments to repair irregular skin pigmentation and the desire to increase or decrease constitutive skin pigmentation, arouses great interest pharmaceutically as well as cosmeceutically. This review discusses the intrinsic biochemistry of pigmentation, details mechanisms that lead to increased or decreased skin pigmentation, and summarizes established and potential hyper-and hypo-pigmenting agents and their modes of action.

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Section: Induction Of Hyperpigmentation -Specific Mechanismsmentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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“…For instances, application of PRP was observed to reduce the incidence of post-inflammatory hyperpigmentation; an effect which might be due to PRP exerting a healing of the basement membrane by laminin, collagen IV, and tenascin stimulated by the TGF-b (24,25) found in the PRP.…”

Section: Discussionmentioning

confidence: 99%

Response to Intradermal Autologous Platelet Rich Plasma Injection in Refractory Dermal Melasma: Report of Two Cases

Amini

Ts²,

Ch³

2015

JUMMEC

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Refractory dermal melasma is resistant to conventional treatment. Platelet rich plasma (PRP) may help to reduce the pigmentation of melasma. We present a case report on the clinical outcome of 2 patients with melasma, given PRP, as an adjunct therapy. PRP was administered at a monthly interval for 2 sessions in combination with a monthly Q-switched Nd Yag laser treatment and topical alpha arbutin application. A modified melasma area and severity index (MASI) was evaluated by two dermatologists who were blinded. At the follow up on the 3 rd months, the MASI score was reduced by mean 33.5% for case 1 and 20% for case 2. There were no clinical complications for case 1. However recurrence of melasma was noted in case 2 by a worsening of the MASI score mean to 53% at the sixth months follow up. In conclusion, intradermal PRP injection as an adjunct to the conventional treatment of melasma presented with differing results in two cases.

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“…Coloured skin is more likely to develop post inflammatory pigmentation, that too with greater severity. 9,10 It may last for months and tends to be more severe in diseases with chronic, recurrent inflammations. 11 Other studies also mention post inflammatory hyperpigmentation to be the second most common cause of dark skin lesions after melasma.…”

Section: Discussionmentioning

confidence: 99%

Hyperpigmented skin conditions: a study of pattern and prevalence from a tertiary care hospital of north india

Adil¹,

Amin²,

Arif³

et al. 2017

Int j curr adv res

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Postinflammatory hyperpigmentation: a common but troubling condition

Cited by 113 publications

References 34 publications

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Response to Intradermal Autologous Platelet Rich Plasma Injection in Refractory Dermal Melasma: Report of Two Cases

Hyperpigmented skin conditions: a study of pattern and prevalence from a tertiary care hospital of north india

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