Postheparin Plasma Lipoprotein and Hepatic Lipase Activities in Hyperinsulinemic Infants of Diabetic Mothers and in Large-for-Date Infants at Birth

Rovamo, Liisa; Taskinen, Marja‐Riitta; Kuusi, Timo; Raivio, Kari O.

doi:10.1203/00006450-198606000-00009

Cited by 7 publications

(3 citation statements)

References 35 publications

(33 reference statements)

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“…In healthy pregnancies, a varying contribution might be made by the genetic background of the fetus. In addition, in macrosomic newborns of healthy mothers, serum lipid, apolipoprotein, and lipoprotein values did not diVer significantly from those of appropriate for gestational age newborns, in agreement with the results of Rovamo et al 34 On the other hand, the infants born to mothers with poorly controlled diabetes might have been exposed to a hyperglycaemic milieu in utero, which resulted in macrosomia.…”

Section: Discussionsupporting

confidence: 90%

Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition

Merzouk

Bouchenak²,

Loukidi³

et al. 2000

Journal of Clinical Pathology

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Aims-To determine the eVects of fetal macrosomia related to maternal type 1 diabetes on the lipid transport system. Methods-Serum lipoprotein concentrations and composition and lecithin:cholesterol acyltransferase (LCAT) activity were investigated in macrosomic newborns (mean birth weight, 4650 g; SEM, 90) and their mothers with poorly controlled type 1 diabetes, in appropriate for gestational age newborns (mean birth weight, 3616 g; SEM, 68) and their mothers with well controlled type 1 diabetes, and macrosomic (mean birth weight, 4555 g; SEM, 86) or appropriate for gestational age (mean birth weight, 3290 g; SEM, 45) newborns and their healthy mothers. Results-In mothers with well controlled type 1 diabetes, serum lipids, apolipoproteins, and lipoproteins were comparable with those of healthy mothers. Similarly, in their infants, these parameters did not diVer from those of appropriate for gestational age newborns. Serum triglyceride, very low density lipoprotein (VLDL), apolipoprotein B100 (apo B100), and high density lipoprotein (HDL) triglyceride concentrations were higher, whereas serum apo A-I and HDL 3 concentrations were lower in mothers with diabetes and poor glycaemic control than in healthy mothers. Their macrosomic newborns had higher concentrations in all serum lipids and lipoproteins, with high apo A-I and apo B100 values compared with appropriate for gestational age newborns. In macrosomic infants of healthy mothers, there were no significant diVerences in lipoprotein profiles compared with those of appropriate for gestational age infants. LCAT activity was similar in both groups of mothers and newborns. Conclusion-Poorly controlled maternal type 1 diabetes and fetal macrosomia were associated with lipoprotein abnormalities. Macrosomic lipoprotein profiles related to poor metabolic control of type 1 diabetes appear to have implications for later metabolic diseases. (J Clin Pathol 2000;53:917-923)

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Section: Discussionsupporting

confidence: 90%

Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition

Merzouk

Bouchenak²,

Loukidi³

et al. 2000

Journal of Clinical Pathology

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“…Fifteen minutes after the injection a blood sample was taken for the measurement of lipase activities. At the ages of 7 and 26 days lipase activities were measured for the first time from 14 and one infants and for the second time from six and seven infants, respectively. As we have found previously the infants showed no signs of a tendency to bleed or other side effects as a result of the heparin administration.…”

Section: Blood and Urinary Samplesmentioning

confidence: 99%

“…The mean urinary acylV free carnitine-ratio was 0-56 (range 0-16-1A0) in the infants who were small for gestational age and (range 1. [5][6][7][8][9][10][11][12][13][14][15] in the infants of appropriate weight.…”

Section: Serum Concentration and Urinary Excretion Of Carnitinementioning

confidence: 99%

Lipoprotein lipase, hepatic lipase, and carnitine in premature infants.

Rovamo

Nikkilä

Raivio

1988

Archives of Disease in Childhood

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SUMMARY Twenty six preterm infants were studied at the age of 2, 7, and 26 days. The activities of lipoprotein and hepatic lipase in plasma taken 15 minutes after a heparin bolus of 100 IU/kg had been given and the concentrations of carnitine in serum and urine were measured. The mean gestational age was 31 weeks (range 26-35 weeks) and birth weight 1580 g (range 840-2280 g). Thirteen infants weighed under 1500 g at birth (very low birth weight), 20 were of appropriate weight for gestational age and six were small for gestational age. Lipoprotein lipase activity was higher in the preterm infants of appropriate weight than in the infants of very low birth weight and those who were small for gestational age. At the age of 2 or 7 days the activity of lipoprotein lipase in the preterm infants (mean (SEM) 46-2 (4.3) ,tmol free fatty acid/mV/hour) was, however, higher than in term infants and adults. Multivariate regression analyses showed that weight and relative birth weight together explained 58% of the variance of lipoprotein lipase activity but only 3% of the variance of hepatic lipase activity. Serum carnitine concentration was lower in the preterm infants than in term infants. Urinary excretion of carnitine increased progressively with age but was independent of serum concentration and carnitine intake. Urinary excretion of total carnitine was significantly greater in the infants who were small for gestational age (mean (SEM) 754 (203) nmol/mg of creatinine, n=6) than in the infants of appropriate weight (161 (22-0) nmol/mg of creatinine, n= 12) but acyl/free carnitine ratio was smaller in the infants who were small for gestational age than in infants of appropriate weight (0-56 v 5-5). The

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Serum lipid and lipoprotein composition in infants of diabetic mothers

et al. 1999

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Diabetes mellitus (DM) alters carbohydrate and lipid metabolism to a great extent. This study was planned to determine whether infants of insulin dependent and gestational diabetic mothers have abnormal lipid metabolism. Three groups of newborns were included in the study; group I consisted of 7 infants of diabetic mothers (IDM) with insulin dependent DM (Type 1 DM), group II of 18 infants of gestational diabetic mothers and group III of 20 control neonates whose mothers had no history of DM. Total cholesterol (TC), triglyceride (TG) and high density lipoprotein-cholesterol (HDL-C) values in groups I and II were no different compared to those in group III (p > 0.05). However, low density lipoprotein-cholesterol (LDL-C) and LDL-C/HDL-C ratio were similar between groups I and II (p > 0.05) but significantly higher in both infants of type 1 diabetic mothers and gestational diabetic mothers compared to control infants (p < 0.05). Apolipoprotein A-I (Apo A-1) and apolipoprotein B (Apo B) levels, Apo A-I/Apo B and HDL-C/Apo A-I ratios were similar in between groups. However, Apo B/LDL-C ratio was significantly lower in groups I and II compared to control group (p < 0.05). In conclusion, diabetes in pregnant women causes a tendency to LDL hypercholesterolemia in the offspring. These infants should be longitudinally followed up to assess whether this observation imposes an increased risk for atherosclerosis for advanced ages.

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Postheparin Plasma Lipoprotein and Hepatic Lipase Activities in Hyperinsulinemic Infants of Diabetic Mothers and in Large-for-Date Infants at Birth

Cited by 7 publications

References 35 publications

Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition

Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition

Lipoprotein lipase, hepatic lipase, and carnitine in premature infants.

Serum lipid and lipoprotein composition in infants of diabetic mothers

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