Lipoprotein lipase, hepatic lipase, and carnitine in premature infants.

Rovamo, Liisa; Nikkilä, Esko A.; Raivio, Kari O.

doi:10.1136/adc.63.2.140

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Furthermore, birth weight and GA were negatively correlated with serum TG levels in our study. These results are consistent with previous studies reporting that body weight and relative birth weight may affect LPL activity [9]. Maturation of lipid metabolism was associated with weight gain rather than aging because body weight, but not postnatal age, showed a negative correlation with serum TG levels.…”

Section: Discussionsupporting

confidence: 92%

Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition

Lim

Choi

Kim

et al. 2013

Pediatr Gastroenterol Hepatol Nutr

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PurposePreterm infants on parenteral nutrition are at a relatively high risk for hypertriglyceridemia because they have immature lipoprotein lipase activity. The purpose of this study was to analyze the clinical factors affecting lipid metabolism in preterm infants receiving parenteral nutrition and to evaluate the influence of intravenous heparin on serum triglycerides to determine the adequate heparin dose to prevent hypertriglyceridemia in preterm infants.MethodsA single-center retrospective review was conducted among preterm infants receiving parenteral nutrition between January 2006 and February 2011. In 75 patients, 110 determinations were performed within 28 days postnatal age. Demographic and clinical data, including laboratory parameters, the dose and the duration of lipid administration, and the amount of intravenous heparin, were analyzed.ResultsSerum triglycerides were higher in the small for gestational age (SGA) infants than in the appropriate for gestational age infants (185.5±134.9 mg/dL vs. 126.9±101.9 mg/dL, p=0.019). Birth weight, gestational age, and body weight were negatively correlated with serum triglyceride level (r=-0.289, p=0.002; r=-0.208, p=0.029; r=-0.287, p=0.002, respectively). The serum triglyceride level was statistically lower in preterm infants receiving 1 U/mL of heparin than in those receiving 0.5 U/mL heparin or no heparin.ConclusionPreterm infants receiving parenteral nutrition, particularly SGA and extremely low birth weight infants, tend to have hypertriglyceridemia. Thus, administration of 1 U/mL of heparin rather than 0.5 U/mL or none may be helpful to prevent hypertriglyceridemia in preterm infants.

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Section: Discussionsupporting

confidence: 92%

Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition

Lim

Choi

Kim

et al. 2013

Pediatr Gastroenterol Hepatol Nutr

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“…However, amongst different control groups, there appear to be wide variations in urinary carnitine levels (9,10,12). In premature infants, urinary excretion of carnitine increased progressively with age, but was independent of serum concentrations and carnitine intake (13). Thus the slow elimination of fat from the circulation of premature infants was thought to be explained by the low serum carnitine concentrations and the high excretion of urinary carnitine.…”

Section: Discussionmentioning

confidence: 99%

Carnitine metabolites in infants with cystic fibrosis: a prospective study

Lloyd-Still¹,

Powers²,

Wessel³

1993

Acta Paediatrica

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Acylcarnitine is low in cord blood in patients with cystic fibrosis, suggesting that fatty acid metabolism is disturbed in utero. Carnitine metabolites (total, free, short- and long-chain acylcarnitine) were measured prospectively in 23 newly diagnosed infants with cystic fibrosis treated with a carnitine-containing, predigested formula for 6-12 months. Total (p < 0.002), free (p < 0.004), and long-chain (p < 0.001) plasma concentrations of carnitines were significantly less than controls (n = 48) at diagnosis. Total and free concentrations were corrected with nutritional management, whereas short- and long-chain acylcarnitines remained unchanged. By three years of age all plasma concentrations of carnitine metabolites were significantly less than controls despite a carnitine-containing diet. Urinary carnitine metabolites were increased at diagnosis and follow-up. The physiological significance of these observations in cystic fibrosis is unknown, but could be compatible with disturbed regulatory control with resultant increased utilization.

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“…Research has shown that premature infants’ lipoprotein lipase activity may be related to their gestational age and birth weight. 18-20 Both De Leeuw et al 18 and Rovamo et al 19 found that the premature infant’s declining birth weight correlated with variance in lipoprotein lipase levels. There was a significant difference in birth weight for infants in our study ( P = .041).…”

Section: Discussionmentioning

confidence: 99%

A Randomized Trial of Micropreemies Receiving Higher Amounts of Intravenous Fat Emulsion During the First Week of Life

Drenckpohl

Niehaus

Schneider

et al. 2011

ICAN: Infant, Child, & Adolescent Nutrition

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Objective. The goal of this study was to determine if micropreemies could tolerate higher infusion rates of intravenous fat emulsions (IVFEs) during the first week of life by maintaining their serum triglyceride levels at <200 mg/dL. Methods. This was a randomized controlled trial of 19 infants who were classified as appropriate for gestational age and had birth weights between 500 and 750 g. The primary clinical outcome was serum triglyceride levels; secondary outcomes also were monitored. Results. A total of 19 micropreemies completed the study (experimental group: n = 10; control group: n = 9). Of the infants in the experimental group, 100% had developed hypertriglyceridemia (>201 g/dL) during the first week of life compared with only 44.4% of the infants in the control group. The experimental group experienced a lower weight loss of 8.6% ± 3.10% as compared with 16.22% ± 8.04% in the control group during the first week of life. Initially, the experimental group was given significantly higher infusion rates of IVFEs, but at the end of the week, the control group was receiving significantly higher infusion rates of IVFEs. Calorie intake was significantly better initially for the experimental group, but because of the incidences of hypertriglyceridemia and a reduction of IVFEs, the control group had significantly better calorie intake at the end of the study period. Conclusions. Micropreemies do not tolerate initial higher infusion rates of IVFEs during the first week of life because of their potential risk for developing hypertriglyceridemia.

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Lipoprotein lipase, hepatic lipase, and carnitine in premature infants.

Cited by 7 publications

References 26 publications

Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition

Clinical Factors Affecting Lipid Metabolism and Optimal Dose of Heparin in Preterm Infants on Parenteral Nutrition

Carnitine metabolites in infants with cystic fibrosis: a prospective study

A Randomized Trial of Micropreemies Receiving Higher Amounts of Intravenous Fat Emulsion During the First Week of Life

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