Posterior Segment Involvement in Ocular Behçet's Disease

Pc, Ozdal; Ortaç, Serap; Taşkintuna, İbrahim; Firat, Esin

doi:10.1177/112067210201200514

Cited by 100 publications

(79 citation statements)

References 25 publications

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“…For that reason, we could not compare patients who presented in the 1990s and 2000s. Behçet's uveitis presents mostly in the form of posterior uveitis or panuveitis, and isolated anterior or intermediate uveitis is rare (32). Consistently, the disease was the leading cause of posterior uveitis (46.1%) and panuveitis (61.0%), and a less common cause of anterior uveitis (9.7%) in our study.…”

Section: Discussionsupporting

confidence: 71%

Epidemiology of uveitis in a referral hospital in Turkey

Özdal¹,

Yazıcı²,

Tüfek³

et al. 2014

Turk J Med Sci

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A series of (E) -3- (3-(2,3-dihydro-3-methyl-2-oxo-3 H -benzoxazole-6-yl)-1-phenyl-1 H -pyrazole-4-yl)acrylamides (7a-k) were synthesized and evaluated for their in vitro inhibitory activities on COX-1 and COX-2 isoforms using a human whole blood assay as well as their antiplatelet profile against human platelet aggregation using arachidonic acid as agonists. Among the synthesized derivatives 7a-k, especially compound 7g exhibited dual anti-inflammatory and antiplatelet activity with selective COX-2 inhibition.

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Section: Discussionsupporting

confidence: 71%

Epidemiology of uveitis in a referral hospital in Turkey

Özdal¹,

Yazıcı²,

Tüfek³

et al. 2014

Turk J Med Sci

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“…This rate was higher than what was found in other literature. [11,[22][23][24] In our study, it was shown that women have a more favorable prognosis than men. This could be related to the higher frequency and preponderance of severe inflammation (retinitis and vasculitis) in men.…”

Section: Discussionmentioning

confidence: 87%

Behçet’s Disease: The Clinical and Demographic Characteristics of 406 Patients

et al. 2012

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Amaç: Bu çalışmada Behçet hastalığı olan kişilerde hastalığın demografik ve klinik özellikleri, prognostik faktörleri, oküler ve sistemik bulgularının tanımlanması ve araştırılması amaçlandı. Hastalar ve yöntemler: Çalışmaya Uluslararası BehçetHastalığı Çalışma Grubu'nun sınıflama kriterlerini karşılayan 406 hasta (306 erkek, 100 kadın; ort. yaş 36.1; dağılım 12-76) dahil edildi. Başlangıç yaşı, cinsiyet, oküler tutulum tipi, görme keskinliği, sistemik bulgular ve başlangıç bulguları dahil olmak üzere klinik ve demografik özellikler ve tedavi yöntemleri gözden geçirildi. Bulgular:Ortalama başlangıç yaşı erkeklerde 27.6±7.2 yıl, kadınlarda ise 29.0±9.3 yıl idi. Oküler tutulum sıklığı (erkeklerde %68.9, kadınlarda %65; p=0.163) ve her iki gözde tutulum sıklığı (erkeklerde %56.2, kadınlarda %53.0; p=0.67) açısından, her iki cinsiyet arasında anlamlı fark yoktu. Hastalığın en sık görülen ilk başlangıç bulgusu %71.9 ile oral aftöz ülser iken, bunu %23.4 ile oküler tutulum izliyordu. Başlıca klinik bulgu oral aftöz ülser iken (%100), bunu genital ülser (%82.8) ve oküler tutulum (%80.3) izliyordu. HLA-B51, 372 hastanın 170'inde pozitifti (%45.7). HLA-B51 pozitifliğinin oküler inflamatuvar atakların sıklığı ve ciddiyeti üzerinde bir etkisi yoktu. Üç yüz altı erkeğin 141'inde (%46.1) ve 100 kadının 29'unda (%29.0) ağır oküler atak mevcut olup, erkeklerin %34.6'sında (n=106) ve kadınların %21'inde (n=21) sık oküler tutulum izlendi. Erkeklerdeki ataklar, kadınlarınkine göre daha sık (p=0.03) ve daha ağırdı (p=0.015). Siklosporin A, sık atak geçirenlerde en sık tercih edilen ilaçtı (%24.3; p=0.019).Sonuç: Behçet hastalığında oküler tutulum erkeklerde anlamlı olarak daha sık ve ağır seyreder. Görme keskinliğini etkileyen başlıca prognostik kriter, oküler tutulumun sıklığı ve şiddetidir.Anahtar sözcükler: Behçet hastalığı; HLA-B51; inflamatuvar atak; üveit; görme prognozu. Objectives:In this study, we aim to describe and investigate the demographic and clinical features, prognostic factors, ocular, and systemic manifestations of the patients with Behçet's Disease. Patients and methods:The study included 406 patients (306 males, 100 females; 36.1 years; range 12 to 76 years) who met the classification criteria of the International Study Group for Behçet's Disease. The clinical and demographic characteristics including age at onset, sex, type of ocular involvement, visual acuity, systemic manifestations, and initial signs, and treatment modalities were reviewed. Results:The mean age at onset was 27.6±7.2 years in male patients and 29.0±9.3 years in females. There were no significant differences between both sex in terms of the frequency of ocular involvement (68.9% in male, 65.0% in female, p=0.163) and bilaterality of the ocular involvement (56.2% in male and 53.0% in female, p=0.67). The most common initial presenting manifestation of the disease was oral aphthous ulcer which was seen in 71.9% of the patients, followed by ocular involvement (23.4%). The leading clinical features were oral aphthous ulcers (100%), followed by g...

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“…In active phase of Behçet's disease, drastic changes in macular such as macular oedema or retinal ischaemia could lead to the direct and persistent damage of the fovea. [15][16][17] We assumed that lack of definition of the IS/OS line on the OCT images reflected disorganization of the photoreceptor layer, and that the decrease in foveal thickness reflected damage of either whole or partial retinal layers. From a different point of view, Atmaca and Sonmez 6 reported the FA and ICGA findings in Behçet's disease.…”

Section: Discussionmentioning

confidence: 99%