Posterior Precuneus is Highly Connected to Medial Temporal Lobe Revealed by Tractography and White Matter Dissection

Jitsuishi, Tatsuya; Yamaguchi, Atsushi

doi:10.1016/j.neuroscience.2021.05.009

Cited by 17 publications

(13 citation statements)

References 55 publications

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“…Instead of directly activating the ECN while disabling the DMN ( Sridharan et al, 2008 ), VENs (as “herald neurons”) would rapidly establish coherence of oscillations between core regions of both networks prior to the phase of actual switching, leading to more efficient functional dissociation and thus decreased DMN interference with task-relevant mental activity originating from the ECN ( Anticevic et al, 2012 ; Bruton, 2021 ). The fact that different subdivisions of the PMC, including the PC, have been implicated in different ICNs ( Margulies et al, 2009 ; Yang et al, 2014 ; Kolb and Whishaw, 2021 ) underlines the importance of efficient internetwork communication especially in this particular parietal area to which VENs could significantly participate in (for additional data on PMC and PC connectome, tractography and white matter dissection, see Baker et al, 2018 ; Assem et al, 2020 ; Jitsuishi and Yamaguchi, 2021 ). An intriguing objective for future research would be to establish whether the observed variation in dendritic architecture and spine features of spindle-shaped neurons, if they are VENs, exhibit individual differences and whether they are correlated with human cognition as reflected by constructs such as g .…”

Section: Discussionmentioning

confidence: 99%

Spindle-Shaped Neurons in the Human Posteromedial (Precuneus) Cortex

Fuentealba-Villarroel

Renner

Hilbig

et al. 2022

Front. Synaptic Neurosci.

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The human posteromedial cortex (PMC), which includes the precuneus (PC), represents a multimodal brain area implicated in emotion, conscious awareness, spatial cognition, and social behavior. Here, we describe the presence of Nissl-stained elongated spindle-shaped neurons (suggestive of von Economo neurons, VENs) in the cortical layer V of the anterior and central PC of adult humans. The adapted “single-section” Golgi method for postmortem tissue was used to study these neurons close to pyramidal ones in layer V until merging with layer VI polymorphic cells. From three-dimensional (3D) reconstructed images, we describe the cell body, two main longitudinally oriented ascending and descending dendrites as well as the occurrence of spines from proximal to distal segments. The primary dendritic shafts give rise to thin collateral branches with a radial orientation, and pleomorphic spines were observed with a sparse to moderate density along the dendritic length. Other spindle-shaped cells were observed with straight dendritic shafts and rare branches or with an axon emerging from the soma. We discuss the morphology of these cells and those considered VENs in cortical areas forming integrated brain networks for higher-order activities. The presence of spindle-shaped neurons and the current discussion on the morphology of putative VENs address the need for an in-depth neurochemical and transcriptomic characterization of the PC cytoarchitecture. These findings would include these spindle-shaped cells in the synaptic and information processing by the default mode network and for general intelligence in healthy individuals and in neuropsychiatric disorders involving the PC in the context of the PMC functioning.

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Section: Discussionmentioning

confidence: 99%

Spindle-Shaped Neurons in the Human Posteromedial (Precuneus) Cortex

Fuentealba-Villarroel

Renner

Hilbig

et al. 2022

Front. Synaptic Neurosci.

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“…Finally, the posterior precuneus is functionally associated with the visual cortex ( 12 , 15 ). The precuneus forms the midline core of the default mode network, a network that is predominantly active during periods of inactivity ( 16 – 18 ). Other brain structures that are included in the default mode network are the PCC and the mesial temporal lobe (MTL).…”

Section: Anatomy and Functional Connectivitymentioning

confidence: 99%

“…Thus, extensive functional connectivity between the precuneus and the MTL is evident in the resting state ( 10 ). Moreover, tractography data and post-mortem analysis have shown extensive projections from the posterior precuneus to the MTL, specifically, the anterior para-hippocampal gyrus ( 16 ). Seizures originating from the precuneus may be clinically silent or potentially cause some alteration of awareness ( 19 , 20 ).…”

Section: Anatomy and Functional Connectivitymentioning

confidence: 99%

The Temporal Lobe as a Symptomatogenic Zone in Medial Parietal Lobe Epilepsy

et al. 2022

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Some surgical failures after temporal lobe epilepsy surgery may be due to the presence of an extratemporal epileptogenic zone. Of particular interest is the medial parietal lobe due to its robust connectivity with mesial temporal structures. Seizures in that area may be clinically silent before propagating to the symptomatogenic temporal lobe. In this paper, we present an overview of the anatomical connectivity, semiology, radiology, electroencephalography, neuropsychology, and outcomes in medial parietal lobe epilepsy. We also present two illustrative cases of seizures originating from the precuneus and the posterior cingulate cortex. We conclude that the medial parietal lobe should be strongly considered for sampling by intracranial electrodes in individuals with nonlesional temporal lobe epilepsy, especially if scrutinizing the presurgical data produces discordant findings.

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“…Cortical areas were defined by the HCP-MMP1.0 parcellation comprising of 360 (180 per hemisphere) regions of interest (ROIs) which localizes brain regions on on inflated brain surfaces (Glasser et al, 2016). Because the DWI reconstruction and tractography methods used in this manuscript require a parcellation in 3D coordinate space, a surface to volume projected version of the HCP-MMP1.0 atlas registered to MNI space and corrected for errors arising from surface-voxel misalignment (as implemented in DSI Studio) was used for the present analyses, as done in previous studies (Huang et al, 2021;Jitsuishi et al, 2020;Jitsuishi and Yamaguchi, 2021;Ghulam-Jelani et al, 2021;Wu et al, 2019). However, it has been shown that using volume-based HCP-MMP1.0 parcellations have higher cortical areal localization uncertainty than surface-based approaches (Coalson et al, 2018).…”

Section: Defining Regions Of Interestmentioning

confidence: 99%

Network Diffusion Embedding Reveals Transdiagnostic Subnetwork Disruption and Potential Treatment Targets in Internalizing Psychopathologies

et al. 2021

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Network diffusion models are a common and powerful way to study the propagation of information through a complex system and they offer straightforward approaches for studying multimodal brain network data. We developed an analytic framework to identify brain subnetworks with perturbed information diffusion capacity using the structural basis that best maps to resting state functional connectivity and applied it towards a heterogeneous dataset of internalizing psychopathologies (IPs), a set of psychiatric conditions in which similar brain network deficits are found across the swath of the disorders, but a unifying neuropathological substrate for transdiagnostic symptom expression is currently unknown. This research provides preliminary evidence of a transdiagnostic brain subnetwork deficit characterized by information diffusion impairment of the right area 8BM, a key brain region involved in organizing a broad spectrum of cognitive tasks, which may underlie previously reported dysfunction of multiple brain circuits in the IPs. We also demonstrate that models of neuromodulation involving targeting this brain region normalize IP diffusion dynamics towards those of healthy controls. These analyses provide a framework for multimodal methods that identify both brain subnetworks with disrupted information diffusion and potential targets of these subnetworks for therapeutic neuromodulatory intervention based on previously well-characterized methodology.

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Posterior Precuneus is Highly Connected to Medial Temporal Lobe Revealed by Tractography and White Matter Dissection

Cited by 17 publications

References 55 publications

Spindle-Shaped Neurons in the Human Posteromedial (Precuneus) Cortex

Spindle-Shaped Neurons in the Human Posteromedial (Precuneus) Cortex

The Temporal Lobe as a Symptomatogenic Zone in Medial Parietal Lobe Epilepsy

Network Diffusion Embedding Reveals Transdiagnostic Subnetwork Disruption and Potential Treatment Targets in Internalizing Psychopathologies

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