Posterior fossa immature teratoma in an infant with trisomy 21: A case report and review of the literature

Bakhtiar, Yuriz; Yonezawa, Hajime; Bohara, Manoj; Hanaya, Ryosuke; Okamoto, Yasuhiro; Sakamoto, Kazuhiko; Yoshioka, Takako; Arita, Kazunori

doi:10.4103/2152-7806.100198

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…Common presenting symptoms and signs of such tumors include symptoms related to the outflow obstruction of cerebrospinal fluid resulting in a headache, vomiting, and papilledema (Table 1) [4, 13]. Moreover, the progressive increase in head size has also been observed in many reported cases including our current case (Table 1) [4, 13–16]. Infants with teratoma present with seizures in around 20% of cases [4, 13].…”

Section: Discussionmentioning

confidence: 58%

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Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

2019

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BackgroundCongenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis.Case presentationA newborn female, diagnosed prenatally with hydrocephalus, is presented at birth with increasing head circumference and Parinaud’s syndrome. Magnetic resonance imaging scans demonstrated a huge posterior fossa tumor with obstructive hydrocephalus. At surgery, through a suboccipital craniotomy, complete excision was achieved of a histological-proven immature teratoma. The infant received adjuvant chemotherapy for 1 year. She had normal neurological development and remained tumor-free through her 20-year follow-up.ConclusionThe authors report this rare case of congenital posterior fossa teratoma with long-term outcome, and the literature is reviewed.

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Section: Discussionmentioning

confidence: 58%

“…After delivery, parents may bring the baby in with a history of progressively increasing head circumference. Other history and examination are suggestive of hydrocephalus, which at this age is usually congenital [4, 15, 16]. Magnetic resonance imaging of the brain with and without gadolinium in such patients is diagnostic for tumor [4].…”

Section: Discussionmentioning

confidence: 99%

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

2019

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Increased incidence of retroperitoneal teratomas and decreased incidence of sacrococcygeal teratomas in infants with Down syndrome

Kobayashi

Sakemi

Yamashita

2013

Pediatr Blood Cancer

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Individuals with Down syndrome (DS) have a unique profile of neoplasms, with a higher incidence of leukemias and a lower incidence of solid tumors than seen in the general population. We recently encountered two cases of infants with DS with retroperitoneal teratoma. After reviewing the literature on teratomas in DS, we found that the incidence of retroperitoneal teratomas was higher and the incidence of sacrococcygeal teratomas was lower in infants with DS than in the general population.

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Multi‐institutional analysis of central nervous system germ cell tumors in patients with Down syndrome

Harris

Graham

Cappellano

et al. 2022

Pediatric Blood & Cancer

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Purpose: Primary germ cell tumors (GCTs) are the most common central nervous system (CNS) neoplasm in patients with Down syndrome (DS). However, a standard of care has not been established due to paucity of data. Methods:A retrospective multi-institutional analysis was conducted, in addition to a comprehensive review of the literature.Results: Ten patients from six institutions (five USA, one Brazil) were identified, in addition to 31 patients in the literature from 1975 to 2021. Of the 41 total patients (mean age 9.9 years; 61% male), 16 (39%) had non-germinomatous germ cell tumors (NGGCTs), 16 (39%) had pure germinomas, and eight (19.5%) had teratomas. Basal ganglia was the most common tumor location (n = 13; 31.7%), followed by posterior fossa (n = 7; 17%). Nine patients (22%) experienced disease relapse or progression, of which four died from tumor progression (one germinoma, three teratomas). Sixteen patients (39%) experienced treatment-related complications, of which eight (50%) died (five germinomas, three NGGCTs). Of the germinoma patients, two died from chemotherapy-related sepsis, one from postsurgery cardiopulmonary failure, one from pneumonia, and one from moyamoya following radiation therapy (RT). Of the NGGCT patients, one died from chemotherapy-related sepsis, one from postsurgical infection, and one from pneumonia following surgery/chemotherapy/RT. Three-year overall survival was 66% for all histological types: 62% germinomas, 79% for NGGCTs, and 53% for teratomas. Conclusion:Patients with DS treated for CNS GCTs are at an increased risk of treatment-related adverse events. A different therapeutic approach may need to be considered to mitigate treatment-related complications and long-term neurocognitive sequelae.

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Posterior fossa immature teratoma in an infant with trisomy 21: A case report and review of the literature

Cited by 9 publications

References 14 publications

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

Increased incidence of retroperitoneal teratomas and decreased incidence of sacrococcygeal teratomas in infants with Down syndrome

Multi‐institutional analysis of central nervous system germ cell tumors in patients with Down syndrome

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