Increased incidence of retroperitoneal teratomas and decreased incidence of sacrococcygeal teratomas in infants with Down syndrome

Kobayashi, Tetsuko; Sakemi, Yoshihiro; Yamashita, Hironori

doi:10.1002/pbc.24693

Cited by 11 publications

(8 citation statements)

References 17 publications

(24 reference statements)

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“…Surgical excision is possible even in bilateral involvement and serum AFP is a reliable method of follow-up to detect recurrence [8]. Association of Down ' s syndrome and retroperitoneal teratoma has been reported but we did not see any patient with Down's syndrome in our series [9]. Gastric teratoma constitutes less than 1% of all germ cell tumors in the pediatric age group [10].…”

Section: Discussionmentioning

confidence: 73%

Extra-Gonadal Teratomas in Atypical Sites in Neonates and Children – Our Experience and Review of the Literature

Mukhopadhyay¹,

Mandal²,

Das³

et al. 2021

COR

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Background: Extra-gonadal teratomas are rare tumors in Pediatric surgical practice. We studied the teratomas of atypical sites attended in our tertiary care center. Aim: Aim of the study was to find out the incidence of pediatric teratomas in atypical sites, clinical presentation and histological variation. Material and Methods: Over 15 years (January 2005 to December 2020), 29 cases of pediatric teratomas in atypical sites were studied. These sites included neck (number-one), retroperitoneum (number-fourteen), adrenal gland (number-two), renal (number-two), gastric(number-three), pancreas (number-one), pulmonary (number-one), floor of the mouth(number-one), oral (number-two), abdominal wall (numberone) and the mesentery (number-one). Patients were treated in the Department of Pediatric Surgery and specimens were reviewed in the Department of Pathology. Age, sex, clinical presentation, investigations (all patients had complete blood examination and alpha-fetoprotein) and imaging (USG of the local part and CECT as guided by the organ of involvement). Results: 29 pediatric teratomas in uncommon sites were reviewed. Out of 14 cases of retroperitoneal teratoma, three were immature. Cervical teratoma in a neonate was mature. Three cases of gastric teratomas were reported as mature. Two cases of adrenal teratomas also showed the histological features of mature teratoma. Renal teratomas (two) were benign. One each of pulmonary teratoma, pancreas and floor of the mouth were reported as mature. Two patients presented with oral teratoma were reported as mature teratomas. One patient had teratoma arising from the abdominal wall and was resected completely (mature teratoma). Teratoma arising from the mesentery also underwent complete resection. Conclusion: A small percentage of Pediatric teratomas occur in atypical sites. In our series, retroperitoneal tumors were predominant. Early surgical excision is the treatment of choice. Malignant change is known to occur in Pediatric teratoma and the patients need long term follow-up.

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Section: Discussionmentioning

confidence: 73%

Extra-Gonadal Teratomas in Atypical Sites in Neonates and Children – Our Experience and Review of the Literature

Mukhopadhyay¹,

Mandal²,

Das³

et al. 2021

COR

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“…[16] Kobayashi et al reported two cases of retroperitoneal teratomas in infants with Down syndrome. [17] Stage et al reported seven infants with Down syndrome having teratomas. Out of these five were retroperitoneal in location.…”

Section: Discussionmentioning

confidence: 99%

Antenatally Diagnosed Suprarenal Mature Cystic Teratoma with Down Syndrome

et al. 2018

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Background: Teratoma is a germ cell tumor (GCT) arising from totipotent stem cells that differentiate into the tissues that are foreign to the anatomic site. Teratoma at the suprarenal location is extremely rare. The associa-tion with the Down syndrome also makes it unusual. Case Report: We are presenting here a case of one-year-old female infant with Down syndrome who had an antenatal diagnosis of right suprarenal mass. Laparotomy revealed a large cystic mass in the right suprarenal location which was completely excised. Right adrenal gland could not be seen separately from the mass. The histological diagnosis was a mature cystic teratoma. Conclusion: Adrenal teratoma is rare and may be considered in the differential diagnosis of antenatally diag-nosed suprarenal lesion. Its association with Down syndrome is rare finding.

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“…Spina bifida was more common in children with cancer than among population-based controls [ 33 ]. Among solid tumors associated with Down syndrome germ cell tumors are the most described [ 40 , 41 ]. One case with renal tumor had an unspecified congenital anomaly of the foot.…”

Section: Discussionmentioning

confidence: 99%

Maternal and Birth Characteristics and Childhood Embryonal Solid Tumors: A Population-Based Report from Brazil

et al. 2016

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BackgroundSeveral maternal and birth characteristics have been reported to be associated with an increased risk of many childhood cancers. Our goal was to evaluate the risk of childhood embryonal solid tumors in relation to pre- and perinatal characteristics.MethodsA case-cohort study was performed using two population-based datasets, which were linked through R software. Tumors were classified as central nervous system (CNS) or non-CNS-embryonal (retinoblastoma, neuroblastoma, renal tumors, germ cell tumors, hepatoblastoma and soft tissue sarcoma). Children aged <6 years were selected. Adjustments were made for potential confounders. Odds ratios (OR) with 95% confidence intervals (CI) were computed by unconditional logistic regression analysis using SPSS.ResultsMales, high maternal education level, and birth anomalies were independent risk factors. Among children diagnosed older than 24 months of age, cesarean section (CS) was a significant risk factor. Five-minute Apgar ≤8 was an independent risk factor for renal tumors. A decreasing risk with increasing birth order was observed for all tumor types except for retinoblastoma. Among children with neuroblastoma, the risk decreased with increasing birth order (OR = 0.82 (95% CI 0.67–1.01)). Children delivered by CS had a marginally significantly increased OR for all tumors except retinoblastoma. High maternal education level showed a significant increase in the odds for all tumors together, CNS tumors, and neuroblastoma.ConclusionThis evidence suggests that male gender, high maternal education level, and birth anomalies are risk factors for childhood tumors irrespective of the age at diagnosis. Cesarean section, birth order, and 5-minute Apgar score were risk factors for some tumor subtypes.

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Increased incidence of retroperitoneal teratomas and decreased incidence of sacrococcygeal teratomas in infants with Down syndrome

Cited by 11 publications

References 17 publications

Extra-Gonadal Teratomas in Atypical Sites in Neonates and Children – Our Experience and Review of the Literature

Extra-Gonadal Teratomas in Atypical Sites in Neonates and Children – Our Experience and Review of the Literature

Antenatally Diagnosed Suprarenal Mature Cystic Teratoma with Down Syndrome

Maternal and Birth Characteristics and Childhood Embryonal Solid Tumors: A Population-Based Report from Brazil

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