Posterior Displacement of the Motor Blood Oxygen Level‐Dependent Functional MRI Signal into the Postcentral Gyrus in Patients with Preoperative Brain Tumor and Healthy Volunteers: Practical Guidelines to Correctly Interpret Functional MRI Findings

Holodny, Andrei I.; Petrovich-Brennan, Nicole M.; Hatzoglou, Vaios; Peck, Kyung K.; Young, Robert J.; Karimi, Sasan

doi:10.3174/ng.2130054

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our routine presurgical planning fMRI experience in brain tumor patients noticed that task-based functional activation of hand motor is not always inside the hand knob. As previously reported (Holodny et al, 2013), the effects of brain tumor on tissue such as degeneration and compression might lead to the displacement of white mater tracts and subsequently the relocation of functional activity within brain networks. These tumor-related white matter changes may act in concert with individual variability to impact the presentation of the eloquent cortices, further affecting the accuracy of ROI position.…”

Section: Discussionmentioning

confidence: 59%

Resting-State Functional Magnetic Resonance Imaging and Probabilistic Diffusion Tensor Imaging Demonstrate That the Greatest Functional and Structural Connectivity in the Hand Motor Homunculus Occurs in the Area of the Thumb

et al. 2018

Self Cite

View full text Add to dashboard Cite

The primary hand motor region is classically believed to be in the "hand knob" area in the precentral gyrus (PCG). However, hand motor task-based activation is often localized outside this area. The purpose of this study is to investigate the structural and functional connectivity driven by different seed locations corresponding to the little, index, and thumb in the PCG using probabilistic diffusion tractography (PDT) and resting-state functional magnetic resonance imaging (rfMRI). Twelve healthy subjects had three regions of interest (ROIs) placed in the left PCG: lateral to the hand knob (thumb area), within the hand knob (index finger area), and medial to the hand knob (little finger area). Connectivity maps were generated using PDT and rfMRI. Individual and group level analyses were performed. Results show that the greatest hand motor connectivity between both hemispheres was obtained using the ROI positioned just lateral to the hand knob in the PCG (the thumb area). The number of connected voxels in the PCG between the two hemispheres was greatest in the lateral-most ROI (the thumb area): 279 compared with 13 for the medial-most ROI and 9 for the central hand knob ROI. Similarly, the highest white matter connectivity between the two hemispheres resulted from the ROI placed in the lateral portion of PCG (p < 0.003). The maximal functional and structural connectivity of the hand motor area between hemispheres occurs in the thumb area, located laterally at the "hand knob." Thus, this location appears maximal for rfMRI and PDT seeding of the motor area.

show abstract

Section: Discussionmentioning

confidence: 59%

Resting-State Functional Magnetic Resonance Imaging and Probabilistic Diffusion Tensor Imaging Demonstrate That the Greatest Functional and Structural Connectivity in the Hand Motor Homunculus Occurs in the Area of the Thumb

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Functional magnetic resonance imaging

Fisicaro¹,

Brennan²,

Holodny³

2022

Handbook of Neuro-Oncology Neuroimaging

View full text Add to dashboard Cite

A Novel Sequence: ZOOMit-Blood Oxygen Level-Dependent for Motor-Cortex Localization

et al. 2019

View full text Add to dashboard Cite

BACKGROUND Use of conventional blood oxygen level-dependent functional magnetic resonance imaging (conventional-BOLD-fMRI) presents challenges in accurately identifying the hand-motor cortex when a glioma involves the ipsilateral hand-knob. Zoomed imaging technique with parallel transmission (ZOOMit)-BOLD is a novel sequence allowing high spatial resolution with a relatively small field of view that may solve this problem. OBJECTIVE To compare the accuracy of ZOOMit-BOLD and conventional-BOLD in hand-motor cortex identification. METHODS A total of 20 patients with gliomas involving the sensorimotor cortex were recruited to identify the hand-motor cortex by both ZOOMit-BOLD and conventional-BOLD. Based on whether the entire or partial glioma directly invaded (was located within) the hand-knob or indirectly affected it by proximity, patients were placed into the involved or uninvolved groups, respectively. Direct cortical stimulation was applied intraoperatively to verify the location of the hand-motor cortex. Overlap indices were used to evaluate the accuracy of the hand-motor cortex identification. An overlap index equal to 0, indicating lack of overlap, was classified as inaccurate classification. RESULTS The accuracy of motor-cortex identification with ZOOMit-BOLD was 100% compared to only 65% with conventional-BOLD. The average overlap index yielded by ZOOMit-BOLD was higher than that of conventional-BOLD, regardless of whether gliomas directly invaded the hand-knob (P = .008) or not (P = .004). The overlap index in the involved group was significantly lower than that in the uninvolved group with both ZOOMit-BOLD (P = .002) and conventional-BOLD (P < .001). CONCLUSION ZOOMit-BOLD may potentially replace conventional-BOLD to identify the hand-motor cortex, particularly in cases in which gliomas directly invade the hand-knob.

show abstract

Posterior Displacement of the Motor Blood Oxygen Level‐Dependent Functional MRI Signal into the Postcentral Gyrus in Patients with Preoperative Brain Tumor and Healthy Volunteers: Practical Guidelines to Correctly Interpret Functional MRI Findings

Cited by 4 publications

References 0 publications

Resting-State Functional Magnetic Resonance Imaging and Probabilistic Diffusion Tensor Imaging Demonstrate That the Greatest Functional and Structural Connectivity in the Hand Motor Homunculus Occurs in the Area of the Thumb

Resting-State Functional Magnetic Resonance Imaging and Probabilistic Diffusion Tensor Imaging Demonstrate That the Greatest Functional and Structural Connectivity in the Hand Motor Homunculus Occurs in the Area of the Thumb

Functional magnetic resonance imaging

A Novel Sequence: ZOOMit-Blood Oxygen Level-Dependent for Motor-Cortex Localization

Contact Info

Product

Resources

About