Posterior Corneal Pigmentation and Fibrous Proliferation by Iris Melanocytes

Cell life on the surface of lens implants

“…The third implant, that was removed after more than 3 years, exhibited an even firmer membrane with more permanent cells. Most of these resembled melanocytes similar to those sometimes seen on the posterior corneal surface [4,5]. There were very few giant cells.…”

“…10). The cells were more bipolar and resembled migrated melanocytes as they may be seen on the posterior corneal surface [4,5]. However, some of the terminal processes of these cells were branching.…”

Cell life on the surface of lens implants

“…The third implant, that was removed after more than 3 years, exhibited an even firmer membrane with more permanent cells. Most of these resembled melanocytes similar to those sometimes seen on the posterior corneal surface [4,5]. There were very few giant cells.…”

“…10). The cells were more bipolar and resembled migrated melanocytes as they may be seen on the posterior corneal surface [4,5]. However, some of the terminal processes of these cells were branching.…”

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

“…Clinical and histopathological evidence of uveitis suggests that the RFM develop as a result of inflammatory exudates, which have organized to form a membrane or induce endothelial metaplasia . In humans, retrocorneal pigmentation is the result of endothelial phagocytosis of free melanin, pigment‐laden macrophages adhered to the endothelium, or the presence of iris melanocytes and/or iris pigmented epithelium on the inner cornea . Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process …”

“…16 In humans, retrocorneal pigmentation is the result of endothelial phagocytosis of free melanin, pigment-laden macrophages adhered to the endothelium, or the presence of iris melanocytes and/or iris pigmented epithelium on the inner cornea. 18,19 Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process. 19 Moderate to severe lymphoplasmacytic panuveitis with macrophages observed in HIK differs substantially to that of ERU, which is characterized by predominantly a lymphoplasmacytic infiltrate with formation of iris follicles.…”

“…18,19 Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process. 19 Moderate to severe lymphoplasmacytic panuveitis with macrophages observed in HIK differs substantially to that of ERU, which is characterized by predominantly a lymphoplasmacytic infiltrate with formation of iris follicles. 20 Other characteristic histologic features of ERU, such as lymphoplasmacytic infiltration of the nonpigmented ciliary epithelium, hypereosinophilic intracytoplasmic inclusion in the nonpigmented epithelium, and hyaline material deposition, was not observed in the HIK eyes.…”

Cell life on the surface of lens implants

“…The third implant, that was removed after more than 3 years, exhibited an even firmer membrane with more permanent cells. Most of these resembled melanocytes similar to those sometimes seen on the posterior corneal surface [4,5]. There were very few giant cells.…”

“…10). The cells were more bipolar and resembled migrated melanocytes as they may be seen on the posterior corneal surface [4,5]. However, some of the terminal processes of these cells were branching.…”

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

“…Clinical and histopathological evidence of uveitis suggests that the RFM develop as a result of inflammatory exudates, which have organized to form a membrane or induce endothelial metaplasia . In humans, retrocorneal pigmentation is the result of endothelial phagocytosis of free melanin, pigment‐laden macrophages adhered to the endothelium, or the presence of iris melanocytes and/or iris pigmented epithelium on the inner cornea . Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process …”

“…16 In humans, retrocorneal pigmentation is the result of endothelial phagocytosis of free melanin, pigment-laden macrophages adhered to the endothelium, or the presence of iris melanocytes and/or iris pigmented epithelium on the inner cornea. 18,19 Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process. 19 Moderate to severe lymphoplasmacytic panuveitis with macrophages observed in HIK differs substantially to that of ERU, which is characterized by predominantly a lymphoplasmacytic infiltrate with formation of iris follicles.…”

“…18,19 Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process. 19 Moderate to severe lymphoplasmacytic panuveitis with macrophages observed in HIK differs substantially to that of ERU, which is characterized by predominantly a lymphoplasmacytic infiltrate with formation of iris follicles. 20 Other characteristic histologic features of ERU, such as lymphoplasmacytic infiltration of the nonpigmented ciliary epithelium, hypereosinophilic intracytoplasmic inclusion in the nonpigmented epithelium, and hyaline material deposition, was not observed in the HIK eyes.…”

Cell life on the surface of lens implants

“…The third implant, that was removed after more than 3 years, exhibited an even firmer membrane with more permanent cells. Most of these resembled melanocytes similar to those sometimes seen on the posterior corneal surface [4,5]. There were very few giant cells.…”

“…10). The cells were more bipolar and resembled migrated melanocytes as they may be seen on the posterior corneal surface [4,5]. However, some of the terminal processes of these cells were branching.…”

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

“…Clinical and histopathological evidence of uveitis suggests that the RFM develop as a result of inflammatory exudates, which have organized to form a membrane or induce endothelial metaplasia . In humans, retrocorneal pigmentation is the result of endothelial phagocytosis of free melanin, pigment‐laden macrophages adhered to the endothelium, or the presence of iris melanocytes and/or iris pigmented epithelium on the inner cornea . Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process …”

“…16 In humans, retrocorneal pigmentation is the result of endothelial phagocytosis of free melanin, pigment-laden macrophages adhered to the endothelium, or the presence of iris melanocytes and/or iris pigmented epithelium on the inner cornea. 18,19 Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process. 19 Moderate to severe lymphoplasmacytic panuveitis with macrophages observed in HIK differs substantially to that of ERU, which is characterized by predominantly a lymphoplasmacytic infiltrate with formation of iris follicles.…”

“…18,19 Iris melanocytes can proliferate on the corneal endothelium and produce fibrilar material (basement membrane) and collagen through a metaplastic process. 19 Moderate to severe lymphoplasmacytic panuveitis with macrophages observed in HIK differs substantially to that of ERU, which is characterized by predominantly a lymphoplasmacytic infiltrate with formation of iris follicles. 20 Other characteristic histologic features of ERU, such as lymphoplasmacytic infiltration of the nonpigmented ciliary epithelium, hypereosinophilic intracytoplasmic inclusion in the nonpigmented epithelium, and hyaline material deposition, was not observed in the HIK eyes.…”