Peripheral Pigmented Placoid Corneal Endotheliopathy

Chen, Liwu G.; Finger, Paul T.; Dhrami-Gavazi, Elona

doi:10.1097/ico.0b013e3182a64833

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…To our knowledge, there have been 5 patients described to have PPPCE in the literature. Chen et al describe 4 asymptomatic patients (mean age, 53 years) with well-circumscribed brown pigmented lesions with scalloped or fimbriated edges located in the peripheral inferior corneal endothelium, similar to this patient. All 4 patients had brown irides.…”

Section: Discussionsupporting

confidence: 53%

Pigmented Corneal Mass in a 59-Year-Old Man With Cutaneous Melanoma

2022

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Section: Discussionsupporting

confidence: 53%

Pigmented Corneal Mass in a 59-Year-Old Man With Cutaneous Melanoma

2022

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“…There are few noncorneal conditions like chronic anterior uveitis, uncontrolled glaucoma, complicated intraocular surgeries, and immune-mediated endotheliopathy, which can cause endothelial dysfunction. [ 12 13 14 15 16 17 18 ] Nonsyphilitic deep interstitial keratitis shown by Holt and Watson had nummular features with vascularization along with inflammatory signs in anterior chamber. [ 10 ] All the above conditions are often symptomatic and are caused by the anterior stromal involvement with vascularization unlike nonvascular posterior opacity or semilunar sign of anterior scleritis.…”

Section: Discussionmentioning

confidence: 99%

Semilunar sign of cornea: A multimodal analysis of the posterior corneal opacity in non-infectious anterior scleritis

Kumar

Agarwal

Chandrasekar

et al. 2022

Indian Journal of Ophthalmology

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Purpose: To analyze the morphological outcomes of the posterior corneal opacity or “semilunar sign” in noninfectious anterior scleritis using multimodal imaging. Methods: This was a prospective observational case series. Patients with anterior scleritis from January 2018 to January 2019 were included. Clinical and demographic data were collected. Posterior cornea was visualized using the digital slit lamp photography (Elite, mega digital vision), spectral domain optical coherence tomography (MS39), and specular count analyzer (EM-3000). “Semilunar sign” was defined by the (1) presence of posterior corneal opacity, (2) concave semilunar pattern, (3) absence of blood vessels, and (4) normal anterior cornea. Incidence, clinical characteristics and significance, correlation with Mantoux sensitivity, and role of multimodal valuation were assessed. Results: Overall 76 eyes of 72 patients were recruited with anterior scleritis. Fifteen eyes of 11 patients (15.3%) presented with semilunar sign. The scleritis was both nonnecrotizing ( n = 8) and necrotizing ( n = 7). The semilunar configuration appeared as isolated ( n = 9) and continuous lesion ( n = 6). The extent was directly related to the scleral disease extent ( P = 0.002). The mean thickness measured 212.5 ± 129.3 mm. The mean central endothelial cell density (ECD) was 2540.8 ± 351.7 cells/mm 2 , which was significantly higher than the involved peripheral cornea ( P = 0.05). The mean surface area of the semilunar sign was 7.7 ± 5.2 mm 2 . There was no significant correlation between the opacity thickness and the best-corrected visual acuity ( P = 0.895, r = −0.39), ECD ( P = 0.52, r = −0.188), and Mantoux ( P = 0.696, r =− 0.142) Conclusion: Corneal semilunar sign of scleritis affected the peripheral cornea and caused no functional abnormality in early presentation. Multimodal analysis can aid in clinical assessment and severity.

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Peripheral Pigmented Placoid Corneal Endotheliopathy

Abstract: Four healthy patients were noted to have PPPCE lesions. Although their etiology remains unknown, PPPCE behavior, morphology, and inferior corneal location suggest an origin from iris stromal melanocytes or iris pigment epithelium.

Cited by 2 publications

References 14 publications

Pigmented Corneal Mass in a 59-Year-Old Man With Cutaneous Melanoma

Pigmented Corneal Mass in a 59-Year-Old Man With Cutaneous Melanoma

Semilunar sign of cornea: A multimodal analysis of the posterior corneal opacity in non-infectious anterior scleritis

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