Posterior capsule fibrosis and intraocular lens design

Hansen, Tina; Otland, Niels; Corydon, Leif

doi:10.1016/s0886-3350(88)80143-3

Cited by 53 publications

(5 citation statements)

References 10 publications

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“…Such cells under go pseudofibrous metaplasia to form fibrous cells with myoepithelial properties leading to posterior capsule wrinkling [11], New IOL designs [12,13], atraumatic surgical techniques [8,9] and decreased postoperative inflammation are considered to lessen SC. Despite this, SC still needs fur ther treatment in many patients.…”

Section: Discussionmentioning

confidence: 99%

“…In children and young adults, 100% of SC is expected 1 year after ECCE [6,7]. The development of SC includes various factors in which the most evident is the prolif eration and migration of remnant lens epithe lial cells of the anterior capsule [8][9][10][11], The opacification of the posterior capsule may be reduced by a thorough atraumatic cortical material clean-up with well-supported IOL on the posterior capsule [12,13] posterior capsulotomy, an expensive inter vention with relative hazards such as rise of intraocular pressure, uveitis, secondary glau coma and retinal detachment [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Prevention of Secondary Cataract by Antimitotic Drugs: Experimental Study

Ismail

Alió²,

Ruiz-Moreno³

1996

Ophthalmic Res

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To prevent the development of secondary cataract, mitomycin C (MC, 0.2 mg/ml) and 5-fluorouracil (5-FU, 50 mg/ml) were introduced in the irrigating solution (BSS Plus) during an extracapsular lens extraction in albino rabbits. Cellular multiplication in the whole lens capsule was quantified by means of flow cytometry. The total number of residual cells in the capsule after lens extraction together with the mitotic phases of the cell cycle were studied. A statistically significant difference (p < 0.005, Student t test) was obtained between the two groups treated with antimitotics when compared with the control group regarding the inhibition of mitosis in the capsular cell population together with the total cell number. However, 5-FU has shown a more potent inhibitory effect than MC (p < 0.005, Student t test). We did not record any ocular complication during a postoperative period of 2 months. MC and 5-FU could be a promising alternative in the prevention of posterior capsule opacification.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention of Secondary Cataract by Antimitotic Drugs: Experimental Study

Ismail

Alió²,

Ruiz-Moreno³

1996

Ophthalmic Res

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“…The surgical technique, IOL biocompatibility and design, age of the patient, and patient host factors influence the development of PCO in humans. The pathophysiology of development of PCO and the association with IOL design are areas of extensive investigation in the human medical field 2–20 …”

Section: Introductionmentioning

confidence: 99%

Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery

Bras¹,

Colitz²,

Saville

et al. 2006

Veterinary Ophthalmology

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Posterior capsular opacification (PCO) is the most common postoperative complication of contemporary cataract surgery. Limited information is available regarding PCO formation and factors that influence PCO development in the dog. Two hundred sixty-five eyes (144 from diabetic dogs and 121 from dogs with breed-related cataracts) were prospectively evaluated for PCO formation for up to 12 months postoperatively. The mean age of all dogs in the study was 7.77 years and diabetic dogs were significantly older than dogs with breed-related cataracts. There were 73 males (61 neutered, 12 intact) and 74 females (70 neutered, 4 intact) in the study. Statistical analysis was performed based on age, breed/size, gender, stage of cataract at the time of surgery, PCO score at each time point, breed-related vs. diabetic cataract, right eyes compared to left eyes, and presence/absence of uveitis. Age and gender did not significantly influence PCO formation. Small and medium-sized breeds developed significantly more PCO in comparison to the large/giant breeds at 2 weeks and 2-4 months postoperatively, but the differences were not significant at later time points. There was an overall significant increase in PCO formation in eyes with early immature cataracts when compared to other stages of cataract up to 4 months postoperatively but not at later time points. There were no statistical differences in PCO score at 6 months or at 1 year postoperatively in eyes with breed-related and diabetic cataracts. Right eyes did not differ from left eyes in PCO score. PCO score significantly increased over time in breed-related and diabetic groups and in the overall population. No difference was found in the degree of PCO formation in eyes with inflammation prior to or after surgery compared with those without inflammation. In summary, age, gender, presence of inflammation, and cause of cataract (breed-related vs. diabetes mellitus) do not influence the development of PCO in canine cataract dogs. Small and medium-sized breeds develop significant PCO earlier than larger breeds. It is important to note that all eyes from all dogs in this study developed PCO in a time dependent manner.

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“…12 Most of the previous studies have compared rates of PCO formation between PMMA, Silicon and acrylic intraocular lenses. 13,14 However, our study focused mainly on analysis of various models (13 models) of acrylic foldable lenses in terms of PCO formation aNd:YAG capsulotomy. We also analysed the average duration for PCO formation following phacoemulsification with various designs and materials of foldable IOLs implanted and their outcomes following YAG Capsulotomy.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Study of Nd:YAG Capsulotomy Following Phacoemulsification

Hegde¹,

Ganesh²,

Brar³

2019

jemds

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A B S T R A C T BACKGROUNDPosterior Capsular Opacification (PCO) or After Cataract is one of the most common delayed postoperative complications of uncomplicated phacoemulsification cataract surgery, which occurs due to the migration of lens epithelial cells (LECs) on the posterior capsule. PCO is primarily treated by Nd:YAG capsulotomy which involves creating an opening in the posterior capsule, thereby improving vision. Our aim was to evaluate the incidence of Posterior Capsular Opacification (PCO) in different types of foldable IOLs and also to estimate the duration between phacoemulsification surgery and PCO formation requiring Nd:YAG capsulotomy. METHODSThis retrospective study included all patients who had undergone Nd:YAG capsulotomy after uncomplicated phacoemulsification surgery with foldable IOL implantation in the past 5 years. Thirteen types of acrylic foldable IOLs were analysed for the incidence and time taken for PCO formation after phacoemulsification surgery. RESULTSA total of 28149 eyes of 27779 patients, with mean age of 69±7.27 years, underwent uncomplicated phacoemulsification with foldable IOL implantation during the study period. 1.3% (354) eyes of 182 males and 162 females underwent Nd:YAG capsulotomy for clinically significant PCO. The overall incidence of hydrophobic and hydrophilic IOLs showing PCO formation was 0.73% and 2.4% respectively, the difference being statistically significant (p=0.042). Individually, the IOL with the highest incidence of PCO formation was SENSAR, 3.75% (AR40e) followed by ULTIMA, 3.47% (ULTIMA AC) while SENSAR-1 (AABOO) and Tecnis1 (ZCBOO) had the lowest incidence of PCO. PCO was seen significantly higher in square edge optic designs compared with round edge (p=0.017), while there was no statistically significant difference between single-and three-piece designs (p=0.21). PCO was significantly higher in IOLs with optic diameter of 6 mm when compared to 5.5 mm (p=0.016). The average duration between phacoemulsification surgery and Nd:YAG capsulotomy was 32±3 months, the duration being significantly less for hydrophilic (27±4 months) than hydrophobic (35±3 months) (p=0.041). CONCLUSIONSThe incidence of PCO formation was more and earlier with hydrophilic than with hydrophobic IOLs. It was more frequently seen with square edge optic design. However, lens design, single-piece or three-piece did not seem to influence the rate of PCO formation.

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Posterior capsule fibrosis and intraocular lens design

Cited by 53 publications

References 10 publications

Prevention of Secondary Cataract by Antimitotic Drugs: Experimental Study

Prevention of Secondary Cataract by Antimitotic Drugs: Experimental Study

Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery

Retrospective Study of Nd:YAG Capsulotomy Following Phacoemulsification

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