Prevention of Secondary Cataract by Antimitotic Drugs: Experimental Study

Ismail, M. M.; Alió, Jorge L.; Ruiz-Moreno, José M.

doi:10.1159/000267875

Cited by 38 publications

(2 citation statements)

References 17 publications

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“…In the EDTA group, appearance of PCO was somewhat delayed; however, by day 28, it was the same as that in the control group. The effectiveness of 5-FU was not as high as in other research that showed its effectiveness to be five times greater than that of a control group [70].…”

Section: Drug Delivery Via Silicone Capsulecontrasting

confidence: 70%

Posterior Capsule Opacification: A Review of Experimental Studies

Konopińska

Młynarczyk

Dmuchowska

et al. 2021

JCM

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Posterior capsule opacification (PCO) is the most common complication of cataract surgery. It causes a gradual deterioration of visual acuity, which would otherwise improve after a successful procedure. Despite recent advances in ophthalmology, this complication has not been eradicated, and the incidence of PCO can be as high as 10%. This article reviews the literature concerning the pathomechanism of PCO and examines the biochemical pathways involved in its formation and methods to prevent this complication. We also review the reported tests performed in cell cultures under laboratory conditions and in experimental animal models and in ex vivo human lens capsules. Finally, we describe research involving human eyes in the clinical setting and pharmacological methods that may reduce the frequency of PCO. Due to the multifactorial etiology of PCO, in vitro studies make it possible to assess the factors contributing to its complications and search for new therapeutic targets. Not all pathways involved in cell proliferation, migration, and contraction of the lens capsule are reproducible in laboratory conditions; moreover, PCO in humans and laboratory animals may be additionally stimulated by various degrees of postoperative reactions depending on the course of surgery. Therefore, further studies are necessary.

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Section: Drug Delivery Via Silicone Capsulecontrasting

confidence: 70%

Posterior Capsule Opacification: A Review of Experimental Studies

Konopińska

Młynarczyk

Dmuchowska

et al. 2021

JCM

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“…In numerous experimental studies, antimetabolites, immunotoxins, and antiinflammatory agents such as 5-fluorouracil, daunomycin, thapsigargin, indomethacin, and others have been reported to significantly inhibit LEC growth in cell cultures. 41,[43][44][45][46][47][48][49][50][51][52] In view of these results, several attempts to prevent PCO using the IOLs themselves as sustained drug delivery devices have been reported. [37][38][39]42 However, a major disadvantage of such preprogrammed passive devices is the lack of any dynamic response.…”

Section: Introductionmentioning

confidence: 99%

Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

et al. 2006

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Tens of millions of cataract surgeries are done every year and the number is increasing heavily. Posterior capsule opacification is the major postoperative complication with an incidence of 10 to 50% within 5 years, depending on the age of the patient. We present a novel approach for secondary cataract treatment in a noninvasive manner. Photochemically triggered drug release from a polymer enables repeated drug applications for cataract treatment years after implantation of the intraocular lens, just when needed. However, light in the visible spectral range must pass through the lens but must not induce drug release. We demonstrate that two-photon absorption photochemistry is a powerful tool to overcome this problem. With wavelengths in the visible regime, a photochemical reaction that requires energies in the UV is triggered. The high intensities needed for this process never occur in any lighting condition in daily lives, but may be easily obtained with focused laser beams routinely used in ophthalmology. The properties of the therapeutic system are specified and the function is demonstrated by in-vitro cell tests. Noninvasive multidose photochemically triggered drug release from implanted intraocular lenses carrying a drug depot may be a therapeutic as well as an economic choice to established treatments of secondary cataracts.

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Selective Death of Lens Epithelial Cells Using Demineralized Water and Triton X-100 With PerfectCapsule Sealed Capsule Irrigation

Maloof¹

2005

Arch Ophthalmol

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Background: Sealed irrigation of the capsular bag after removal of the cataractous lens isolates the interior of the capsular bag from the anterior segment, permitting isolated targeting of lens epithelial cells (LECs) in vivo using pharmacologic agents while minimizing the risk of damage to other intraocular structures.Objectives: To assess the ability to deliver a nonspecific, extremely toxic agent (Triton X-100) directly to the LECs after crystalline lens removal, and to assess the eyes histologically for evidence of collateral damage.Methods: Twelve eyes from 6 New Zealand White rabbits were divided into 3 groups of 4 eyes that underwent phacoaspiration of the crystalline lens. Group 1 was a control. In group 2, the anterior segment was irrigated with Triton X-100 and demineralized water for injection for 5 minutes. In group 3, the lens capsule was isolated from the anterior segment using sealed capsule irrigation (SCI) with PerfectCapsule (Milvella Pty Ltd, Sydney, Australia). After surgery, the rabbits were humanely euthanized. The enucleated eyes were immediately fixed in 10% neutral buffered formalin, histological analysis was performed to assess the corneal endothelium, iris, and retina, and the capsular bag and residual equatorial LECs were assessed.Results: The capsular bag was sealed and inflated under SCI in all treated eyes in group 3. Histological evaluation revealed no evidence of collateral damage in group

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Prevention of Secondary Cataract by Antimitotic Drugs: Experimental Study

Cited by 38 publications

References 17 publications

Posterior Capsule Opacification: A Review of Experimental Studies

Posterior Capsule Opacification: A Review of Experimental Studies

Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

Selective Death of Lens Epithelial Cells Using Demineralized Water and Triton X-100 With PerfectCapsule Sealed Capsule Irrigation

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