Poster 38 Safety and Effectiveness of Anticoagulants in Thromboprophylaxis after Hip and Knee Replacement Surgery at an Inpatient Rehabilitation Hospital

Abstract

more units of blood. Minor bleeding events were defined as epistaxis, hemoccult stools, hematuria or hematoma Results or Clinical Course: Analysis of 1766 records demonstrated 1412 patients on warfarin, 218 on fondaparinux, 101 on rivaroxaban and 35 on enoxaparin. Patients treated with warfarin had major bleed incidence 0.85% (n¼12), minor bleed incidence 3.5 % (n¼49) and DVT/PE incidence 2.4% (n¼ 34).Those on fondaparinux had major bleed incidence 0.9% (n¼2), minor bleed incidence 2.3% (n¼ 5) and DVT/PE incidence 0.4% (n¼1). Those on rivaroxaban had no major bleeds, minor bleed incidence of 2% (n¼2) and no DVT/PE. Those on enoxaparin had major bleed incidence 2.8% (n¼1), minor bleed incidence 2.8% (n¼1) and no DVT/PE. Conclusions: Rivaroxaban and enoxaparin were most effective in that there were no incidences of DVT/PE; this was followed by fondaparinux. Warfarin was least effective with greater incidence of DVT/PE. Safety as measured by major bleeds was least in enoxaparin treated group, followed by fondaparinux and warfarin. Rivaroxaban was safest with no major bleeds and it was also favorable due to oral administration and not needing dose monitoring.