Postanginal sepsis

Shapiro, Jo; Fried, Marvin P.; Strome, Marshall

doi:10.1002/hed.2880110210

Cited by 5 publications

(3 citation statements)

References 16 publications

(3 reference statements)

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“…Cases of this type formed the major element of Lemierre's seminal paper "on certain anaerobic septicemias" (239). However, some reported cases have had local complications such as deep neck space infection and mediastinitis without metastatic lesions (274,341). …”

Section: Postanginal Sepsismentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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Section: Postanginal Sepsismentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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“…Septic internal jugular vein thrombophlebitis (SIJVT) caused by oropharyngeal infection, or Lemierre's syndrome, is a rare condition with fewer than 100 cases reported in the western literature since 1974. The syndrome is also known as postanginal sepsis and necrobacillosis 1 – 3 . Fusobacterium necrophorum , an anaerobic gram‐negative bacillus, is the most common pathogen.…”

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confidence: 99%

“…The syndrome is also known as postanginal sepsis and necrobacillosis. [1][2][3] Fusobacterium necrophorum, an anaerobic gram-negative bacillus, is the most common pathogen. Previously healthy young adults and adolescents are most frequently affected.…”

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confidence: 99%