Lemierre's syndrome

Vandenberg, Steven J.; Hartig, Gregory K.

doi:10.1016/s0194-5998(98)70114-7

Cited by 20 publications

(21 citation statements)

References 8 publications

(8 reference statements)

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“…3 Although pharyngitis (often viral) is the most common antecedent otoloaryngological infection, 4 other infections such as peritonsillar abscesses and otitis media have also been implicated. The key factor in the progression of the disease from an otolaryngologic infection to systemic septic emboli is the invasion of deep neck tissues by anaerobic oral pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…The key factor in the progression of the disease from an otolaryngologic infection to systemic septic emboli is the invasion of deep neck tissues by anaerobic oral pathogens. 1,3,5,6 A resultant septic thrombophlebitis of the internal jugular vein acts as a seeding point for septic thromboemboli.…”

Section: Discussionmentioning

confidence: 99%

“…The most common sites of metastasis are the lungs; 1,3,4,6 however, meningitis, osteomyelitis, septic arthritis of the ankle, hips and shoulders, as well as abscesses of the spleen, paravertebral muscles, thigh and skin have been reported, suggesting aggressive systemic dissemination. 2 Rarely, this syndrome is associated with headache, 5 carotid thrombosis, 6 and mediastinitis secondary to extension along the carotid sheath.…”

Section: Discussionmentioning

confidence: 99%

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Lemierre syndrome in a child with recent pharyngitis

Busko

Triner²

2004

CJEM

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A 14-year-old boy presented with fever and progressive respiratory distress, one week after an episode of pharyngitis. Although there was a concern about pulmonary embolism secondary to a lower extremity fracture, his presentation was most consistent with Lemierre syndrome. This syndrome is an uncommon but potentially lethal complication of otolaryngological infections. Early recognition and aggressive antibiotic therapy are critical elements in reducing mortality. Emergency physicians should be aware of this syndrome because its incidence appears to be increasing. RÉSUMÉUn adolescent âgé de 14 ans s'est présenté à l'urgence avec de la fièvre et une détresse respiratoire progressive, une semaine après un épisode de pharyngite. Bien qu'une embolie pulmonaire découlant d'une fracture à une extrémité inférieure ait été évoquée, les symptômes de présenta-tion étaient plus évocateurs du syndrome de Lemierre. Ce syndrome est une complication peu courante mais potentiellement fatale des infections oto-laryngologiques. Son identification pré-coce et une antibiothérapie agressive sont des éléments cruciaux dans la réduction de la mortalité. Les médecins d'urgence doivent être sensibilisés à ce syndrome, car son incidence semble être en hausse.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lemierre syndrome in a child with recent pharyngitis

Busko

Triner²

2004

CJEM

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“…The patients are usually healthy with no evidence of immunocompromise. Patients with Lemierre syndrome commonly present with sepsis after apparent resolution of an acute pharyngitis [32].…”

Section: Epidemiologymentioning

confidence: 99%

“…Once thrombophlebitis of the IJV occurs, septic emboli can arise and spread to distant sites and organs. The most common sites of metastasis are the lungs [7,14,20,32]; however, meningitis, osteomyelitis, septic arthritis of the ankle, hips, and shoulders, as well as abscesses of the spleen, paravertebral muscles, thigh, and skin have been reported, suggesting aggressive systemic dissemination [28]. Rarely, this syndrome is associated with headache, carotid thrombosis, and mediastinitis secondary to extension along the carotid sheath [20,31].…”

Section: Pathogenesismentioning

confidence: 99%

Eponym

Vargiami

Zafeiriou

2010

Eur J Pediatr

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Fig. 1 Dr. Andre Lemierre Lemierre syndrome, also known as postanginal sepsis, is a severe complication of an acute oropharyngeal infection that results in septic thrombophlebitis of the ipsilateral internal jugular vein with subsequent septicemia, often complicated by metastatic infections. The usual agent in Lemierre syndrome is Fusobacterium necrophorum, a commensal bacillus of the oral cavity. After the advent of antibiotic therapy, especially in the 1960s and 1970s, when penicillin was frequently used to treat pharyngeal infections, Lemierre syndrome was often referred to as the "forgotten disease". Today with increasing antibiotic-resistant organisms and decreasing awareness of the syndrome, subsequent reemergence of this syndrome is becoming more common in clinical settings. The syndrome starts initially as an acute oropharyngeal infection followed by septicemia with intense fevers, rigors, swelling, and tenderness on the lateral aspect of the neck, parallel to the sternomastoid muscle (septic internal jugular vein thrombophlebitis), and multiple metastatic infections.

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